Benign myoepithelioma of the salivary glands: a true entity?

Abstract:

:Myoepithelioma is a rare neoplasm of the salivary glands which is now recognized as an individual entity in the revised WHO classification. In this study, eleven benign tumours are presented. Most patients gave a history of a slowly enlarging mass, which was cured by surgical excision. However, one case recurred several times over 50 years, and another still has residual tumour and removal is not possible. The histological appearances included solid, myxoid and reticular growth patterns, composed predominantly of spindle shaped or plasmacytoid (hyaline) cells. Many of the tumours also contained occasional small ducts. All 11 tumours were positive for S-100 protein, variable reactions being seen for various other antigens--keratins, human milk fat globulin, carcinoembryonic antigen, alpha smooth muscle actin and vimentin. It is probable that myoepithelioma constitutes one end of a biological spectrum which also includes pleomorphic adenoma and some (non-membranous) basal cell adenomas. In practice, however, we still advocate retention of myoepithelioma as a separate diagnostic category, on the grounds that it has a range of distinctive microscopic appearances and poses its own unique problems in correct identification.

journal_name

Histopathology

journal_title

Histopathology

authors

Simpson RH,Jones H,Beasley P

doi

10.1111/j.1365-2559.1995.tb00284.x

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

1-9

issue

1

eissn

0309-0167

issn

1365-2559

journal_volume

27

pub_type

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