Abstract:
:Pulmonary hypertension has a complex pathobiology and the term pulmonary arterial hypertension (PAH) includes a variety of pulmonary hypertensive diseases that have different aetiologies, but which may have a similar clinical presentation and, in some cases, the same response to medical treatment. More recent classifications have been based on aetiology, functional data and clinical presentation, but morphometric studies have shown differences in the distribution and prevalence of vascular changes amongst cases of PAH of different aetiologies. Recent advances in the understanding of some aspects of the genetic and molecular mechanisms, together with detailed descriptions of the histopathological findings in PAH cases of different aetiologies, should contribute to a better understanding of the relationships of the various subsets of the disease, the prognostic implications and possible treatment options.
journal_name
Histopathologyjournal_title
Histopathologyauthors
Stewart S,Rassl Ddoi
10.1111/j.1365-2559.2008.03180.xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
104-16issue
1eissn
0309-0167issn
1365-2559pii
HIS3180journal_volume
54pub_type
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