Abstract:
:Intravenous injection of eight human strains of Campylobacter fetus ss fetus and Campylobacter jejuni into mice at various stages of pregnancy demonstrated significant strain differences in ability to affect implantation of the fertilised ovum and to cause resorption of the mouse fetus. Implantation was significantly impaired when C. fetus ss fetus was injected intravenously on day 2 of pregnancy, but no effect was observed in mice receiving C. jejuni. On day 6 of pregnancy, before the development of placental circulation, both C. fetus ss fetus and C. jejuni impaired fetal growth; one strain of C. jejuni had a greater effect than others of the same species. In animals inoculated on day 13 of pregnancy, after the development of placental circulation, six of the eight campylobacter strains caused resorption of the mouse embryos. A similar effect on the embryos was observed after injection of heat-killed organisms, and endotoxin-like substances may have been responsible. It is also suggested that factors other than endotoxin-like substances have a deleterious effect on embryonic growth.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
O'Sullivan AM,Doré CJ,Coid CRdoi
10.1099/00222615-25-1-7subject
Has Abstractpub_date
1988-01-01 00:00:00pages
7-12issue
1eissn
0022-2615issn
1473-5644journal_volume
25pub_type
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pub_type: 临床试验,杂志文章
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更新日期:2000-06-01 00:00:00
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更新日期:1992-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00