The effect of nebulised pentamidine on the concentration of intra-oral Candida albicans in HIV-infected patients.

Abstract:

:This prospective study investigated whether oral candidal carriage in HIV-infected patients was altered by pentamidine therapy. Repeated oral rinses were taken from 56 HIV-positive patients over a 2-year period. Oral candidal carriage was investigated in two groups of patients, one receiving prophylactic pentamidine therapy and the other not receiving regular prophylaxis. Patients receiving pentamidine had lower concentrations of Candida albicans intra-orally than patients who did not receive it. Furthermore, patients who received pentamidine at one stage of the study, but not another, also had lower concentrations of C. albicans intra-orally when receiving pentamidine. These findings indicate that pentamidine is useful as a local agent for prophylaxis against intra-oral candidosis in HIV-infected patients.

journal_name

J Med Microbiol

authors

Nolan A,Lamey PJ,MacFarlane TW,Aitchison TC,Shaw J,Sirel JY

doi

10.1099/00222615-41-2-95

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

95-7

issue

2

eissn

0022-2615

issn

1473-5644

journal_volume

41

pub_type

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