Characterisation of and polysaccharide production by amoxycillin-resistant streptococci.

Abstract:

:Small numbers of bacteria capable of growing on agar supplemented with amoxycillin 40 mg/L were isolated from the saliva of 9 out of 20 adult volunteers in a previous study. All the bacteria were identified as Streptococcus sanguis although no strains produced dextran in conventional tests. However, using a specific assay, all the antibiotic-resistant strains were found to secrete glucosyltransferases (GTF), the enzymes that synthesise these extracellular polysaccharides; the production of GTF-S, the enzyme that synthesizes dextran, was 22-43% less than that of an antibiotic-sensitive control strain. Enzyme production by both antibiotic-resistant and sensitive bacteria was markedly inhibited by dextran primer. The amoxycillin-resistant bacteria were resistant to other penicillins; their resistance to erythromycin was variable but they were uniformly sensitive to cephalothin and clindamycin. As dextran production has been proposed as a key factor in the colonisation of damaged heart valves by bacteria such as S. sanguis, these highly resistant bacteria may not pose a threat to the susceptible individual.

journal_name

J Med Microbiol

authors

Marsh PD,West AA,Keevil CW

doi

10.1099/00222615-24-3-259

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

259-62

issue

3

eissn

0022-2615

issn

1473-5644

journal_volume

24

pub_type

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