Abstract：
:Neuroblastoma, a malignancy of the developing peripheral nervous system that affects infants and young children, is a complex genetic disease. Over the past two decades, significant progress has been made toward understanding the genetic determinants that predispose to this often lethal childhood cancer. Approximately 1-2% of neuroblastomas are inherited in an autosomal dominant fashion and a combination of co-morbidity and linkage studies has led to the identification of germline mutations in PHOX2B and ALK as the major genetic contributors to this familial neuroblastoma subset. The genetic basis of "sporadic" neuroblastoma is being studied through a large genome-wide association study (GWAS). These efforts have led to the discovery of many common susceptibility alleles, each with modest effect size, associated with the development and progression of sporadic neuroblastoma. More recently, next-generation sequencing efforts have expanded the list of potential neuroblastoma-predisposing mutations to include rare germline variants with a predicted larger effect size. The evolving characterization of neuroblastoma's genetic basis has led to a deeper understanding of the molecular events driving tumorigenesis, more precise risk stratification and prognostics and novel therapeutic strategies. This review details the contemporary understanding of neuroblastoma's genetic predisposition, including recent advances and discusses ongoing efforts to address gaps in our knowledge regarding this malignancy's complex genetic underpinnings.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Ritenour LE,Randall MP,Bosse KR,Diskin SJdoi
10.1007/s00441-018-2820-3subject
Has Abstractpub_date
2018-05-01 00:00:00pages
287-307issue
2eissn
0302-766Xissn
1432-0878pii
10.1007/s00441-018-2820-3journal_volume
372pub_type
杂志文章,评审abstract：:Nerves containing the calcium-binding protein calretinin have been reported in several organs but not in female reproductive organs and associated ganglia. This study was undertaken to determine if nerves associated with the uterus contain calretinin and the source(s) of calretinin-synthesizing nerves in the rat (are ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004419900071
更新日期：1999-10-01 00:00:00
abstract：:Neural lobes of rats subjected to dehydration by drinking 2% saline for four days were examined electron microscopically and compared to untreated controls. The ultrastructure of the blood vessels and the tissues surrounding them were examined and it was found that, although few exocytotic figures could be seen in eit...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221710
更新日期：1975-06-24 00:00:00
abstract：:The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the principal molecular units for fast excitatory synaptic transmission in the central nervous system. The glutamate-mediated transmission efficiency of synaptic AMPA receptors is influenced by their subunit composition (GluR-A to GluR-D...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-006-0275-4
更新日期：2006-11-01 00:00:00
abstract：:The origin and renewal of the argentaffin cells in the pyloric glands of hamsters were studied by flash, cumulative and pulse labelling autoradiography with 3H-thymidine. The argentaffin cells were identified by the Diazo Method using Fast Red B Salt. By flash labelling autoradiography, it was shown that the argentaff...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00222771
更新日期：1977-06-20 00:00:00
abstract：:Wnts are secreted glycoproteins that play multiple roles in early development, including the differentiation of precursor cells. During this period, gradients of Wnts and other morphogens are formed and regulate the differentiation and migration of neural progenitor cells. Afterwards, Wnt signalling cascades participa...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-014-1996-4
更新日期：2015-01-01 00:00:00
abstract：:The cerebral ganglia of the freshwater snail Lymnaea stagnalis contain two clusters of neurosecretory Caudo-Dorsal Cells (CDC). These cells produce a neurohormone which stimulates ovulation. Ganglion transplantation and quantitative electron microscopy show that neuronal isolation of the cerebral ganglia complex (CCC)...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219720
更新日期：1976-04-28 00:00:00
abstract：:Molting in shrimp is controlled by the molt-inhibiting hormone (MIH) and ecdysone. MIH inhibits the synthesis of ecdysone in the Y-organ, resulting in molt suppression; it is a neuropeptide member belonging to the eyestalk CHH/MIH/GIH family. The cloning of MIH (formerly MIH-like) of the shrimp Metapenaeus ensis has b...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410000299
更新日期：2001-01-01 00:00:00
abstract：:In fresh-water turtles, the bridge connecting the proximal and caudal stumps of transected spinal cords consists of regenerating axons running through a glial cellular matrix. To understand the process leading to the generation of the scaffold bridging the lesion, we analyzed the mitotic activity triggered by spinal i...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-011-1173-y
更新日期：2011-06-01 00:00:00
abstract：:We have previously shown that immunoneutralization of transforming growth factor-beta (TGF-beta) in the chick embryo significantly reduces programmed cell death (PCD) in peripheral neurons, spinal cord, and retina. In order to validate these results we have begun to analyze PCD in mice with targeted ablations of the T...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-003-0761-x
更新日期：2003-07-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-010-1013-5
更新日期：2010-09-01 00:00:00
abstract：:Rat quiescin/sulphydryl oxidase (rQSOX) introduces disulphide bridges into peptides and proteins with the reduction of molecular oxygen to hydrogen peroxide. Its occurrence has been previously highlighted in a wide range of organs by reverse transcription-polymerase chain reaction (RT-PCR) and Northern blot analyses, ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-005-0043-x
更新日期：2006-01-01 00:00:00
abstract：:We describe the neurons regulating two separate functions of the pharyngeal retractor muscle (PRM), namely sustained contraction during body withdrawal and rhythmic phasic contractions during feeding, in the snail, Helix pomatia. The distribution of central neurons innervating the PRM is organized into two main units;...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-005-1144-2
更新日期：2005-08-01 00:00:00
abstract：:For the study of the hypothalamo-hypophysial system of Xenopus laevis tadpoles, hypothalamic lesions were made by means of the electrocoagulation technique. Lesioning of the ventral region of the preoptic nucleus resulted in a decrease of the number of ACTH cells in the pars distalis of the pituitary gland and in a di...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219304
更新日期：1976-06-11 00:00:00
abstract：:Right superior cervical sympathectomy was performed in one-day old rats. This operation had a small but definite effect on the postnatal development of the submandibular gland. The gland on the sympathectomized side weighed less and contained smaller amounts of DNA, RNA and protein than the contralateral intact gland....
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00227032
更新日期：1977-05-10 00:00:00
abstract：:The existence of the surface-connected canalicular system (SCCS) has been demonstrated in semithick sections of the frog thrombocytes by the use of a high voltage electron microscope. The SCCS of the thrombocytes in Rana catesbeiana and Rana nigromaculata consists of numerous canaliculi and vesicles with a diameter of...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00237001
更新日期：1979-10-01 00:00:00
abstract：:Bovine granulosa cells from 3-7 mm follicles were cultured without anchorage in soft agar/methylcellulose solution for 14 days, with or without 50 ng/ml basic fibroblast growth factor. The granulosa cells divided to form colonies of cells. These were analysed by light and electron microscopy, immunohistochemistry and ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318878
更新日期：1995-12-01 00:00:00
abstract：:Dental pulp stem cells (DPSCs) are an attractive alternative mesenchymal stem cell (MSC) source because of their isolation simplicity compared with the more invasive methods associated with harvesting other MSC sources. However, the isolation method to be favored for obtaining DPSC cultures remains under discussion. T...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-013-1630-x
更新日期：2013-07-01 00:00:00
abstract：:The evolution of aquaporin-5 (AQP5) expression during postnatal development has not been defined in the sweat gland. Previous studies have suggested that AQP isoforms in several peripheral targets are regulated by a neural mechanism. We have examined, in rat sweat glands, the expression of AQP5 during postnatal develo...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0399-1
更新日期：2007-07-01 00:00:00
abstract：:Nerve fibers connecting the brain with the pineal gland of the Mongolian gerbil (central pinealopetal fibers) were investigated by means of light and electron microscopy. Several myelinated fibers penetrate from the brain into the deep pineal gland, extend further into the pineal stalk and continue to the superficial ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00213804
更新日期：1983-01-01 00:00:00
abstract：:Calcitonin receptor-immunoreactivity (CTR-ir) was found in enteric neurons of the mouse gastrointestinal tract from embryonic day 13.5 (E13.5) to post-natal day 28 (P28). CTR-ir occurred in cell bodies in ganglia of the myenteric plexus extending from the esophagus to the colon and in nerve cells of the submucosal gan...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-011-1303-6
更新日期：2012-02-01 00:00:00
abstract：:Antibodies raised against the cystic fibrosis transmembrane regulator protein (CFTR) were used to localize CFTR in intestinal tissues of piglets and mice. Positive staining for CFTR was detected in goblet cells of both species. A second population of epithelial cells of unknown phenotype was also labeled by anti-CFTR ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050531
更新日期：1996-02-01 00:00:00
abstract：:Estradiol injections increase serum level of calcium, amino acid, glucose, protein, ammonia and creatinine in immature Epinephelus akaara, and also increase levels of total lipid, cholesterol, phospholipid and esterified fatty acids. Hepatic protein, glycogen and lipid concentrations also rise after estradiol treatmen...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00217235
更新日期：1984-01-01 00:00:00
abstract：:Previous immunochemical investigations have demonstrated various opioid peptides in the pancreas. However, controversies exist related to the cellular localization of these peptides in the endocrine pancreas. Therefore, the guinea pig endocrine pancreas was immunohistochemically investigated for the presence of opioid...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318454
更新日期：1990-02-01 00:00:00
abstract：:The azygos vein of the rat can be divided into three regions: The proximal cardiac region, where the wall is composed of two and sometimes three layers of cardiac muscle and a thin discontinuous layer of smooth muscle cells. Vascular casts of this region demonstrate layers of capillaries closely following the orientat...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221867
更新日期：1986-01-01 00:00:00
abstract：:To identify anterior pituitary cell types containing GnRH binding sites and to study the internalization process of this peptide by target cells under physiological conditions, autoradiography was performed on rat anterior pituitaries removed at specific time intervals (2-60 min) after intravenous injection of mono-ra...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216482
更新日期：1987-06-01 00:00:00
abstract：:Communication between individuals is critical for species survival, reproduction, and expansion. Most terrestrial species, with the exception of humans who predominantly use vision and phonation to create their social network, rely on the detection and decoding of olfactory signals, which are widely known as pheromone...
journal_title：Cell and tissue research
pub_type： 杂志文章,评审
doi：10.1007/s00441-020-03376-6
更新日期：2021-01-12 00:00:00
abstract：:PC12 pheochromocytoma cells treated with nerve growth factor (NGF) in combination with high concentrations of the activators of adenylate cyclase, forskolin or cholera toxin, become more neuron-like in size than cells treated with NGF or with activators of adenylate cyclase alone. Cells treated simultaneously with NGF...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215430
更新日期：1987-07-01 00:00:00
abstract：:Since the advent of transmission electron microscopy of tissues capable of growth and regeneration, cell and developmental biologists have postulated that the undifferentiated cells observed within these tissues represent tissue-specific stem or progenitor cells. However, no studies have addressed the issue of whether...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-002-0641-9
更新日期：2002-12-01 00:00:00
abstract：:Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cell (MSC) characterized by multi-lineage differentiation making it an attractive choice for tissue regeneration. However, before DPSCs can be used for cell-based therapy, we have to understand their biological properties in response to intrinsic and extrin...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-014-1799-7
更新日期：2014-05-01 00:00:00
abstract：:Two dozen hybrid clones were produced by fusion of diploid embryonic stem (ES) cells positive for green fluorescent protein (GFP) with tetraploid fibroblasts derived from DD/c and C57BL-I(I)1RK mice. Cytogenetic analysis demonstrated that most cells from these hybrid clones contained near-hexaploid chromosome sets. Ad...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-010-0987-3
更新日期：2010-06-01 00:00:00
