Abstract：
:Since the advent of transmission electron microscopy of tissues capable of growth and regeneration, cell and developmental biologists have postulated that the undifferentiated cells observed within these tissues represent tissue-specific stem or progenitor cells. However, no studies have addressed the issue of whether these undifferentiated, putative stem cells persist in growth senescent tissues. Serially transplanted mammary epithelium consistently displays growth senescence beginning at the third transplant generation. This process is not uniform throughout the transplanted population and complete growth quiescence for all portions of a given outgrowth is reached subsequent to the 6th transplant generation. Mammary epithelial cells bearing the morphological characteristics of undifferentiated stem cells likewise disappear from senescent populations simultaneous with growth cessation. In premalignant mammary epithelial populations, which exhibit indefinitely prolonged growth potential, both of these cell types are maintained. This observation provides further support for the conclusion that these ultrastructurally distinct mammary cells represent the mammary stem/progenitor cell population.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Smith GH,Strickland P,Daniel CWdoi
10.1007/s00441-002-0641-9keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
313-20issue
3eissn
0302-766Xissn
1432-0878journal_volume
310pub_type
杂志文章abstract：:Brains and subesophageal ganglia from day 3.5 fifth stadium larvae of Manduca sexta were incubated in vitro with 4 nM tritiated ponasterone A, a 20-hydroxyecdysone analog, to determine whether uptake and specific binding of ecdysteroids occur at a cellular level. These tissues, which were taken just prior to the commi...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318414
更新日期：1991-01-01 00:00:00
abstract：:The formylpeptide receptor (FPR), previously found only on polymorphonuclear leukocytes and monocytes/macrophages, responds to both synthetic N-formyl oligopeptides and those produced by bacteria. The cDNA for human FPR has been cloned and a rabbit polyclonal antiserum directed against a synthetic 11-amino-acid peptid...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410051042
更新日期：1998-04-01 00:00:00
abstract：:We have recently identified a tachykinin-related peptide (AmTRP) from the mushroom bodies (MBs) of the brain of the honeybee Apis mellifera L. by using direct matrix-assisted laser desorption/ionization with time-of-flight mass spectometry and have isolated its cDNA. Here, we have examined prepro-AmTRP gene expression...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-004-0865-y
更新日期：2004-05-01 00:00:00
abstract：:Dysfunction of the retinal pigmented epithelium (RPE) is one of the first effects of dry age-related macular degeneration (AMD) with consequent blindness. Hence, patients affected by this retinal disorder could benefit from a cell-based transplantation strategy for RPE. Actually, an effective protocol to approach this...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-015-2185-9
更新日期：2015-10-01 00:00:00
abstract：:Two types of mitochondria-rich cells were found in the interplatelet areas of the gills of the migrating river lamprey. Both cell types are thought to be responsible for ion-transport across the gills. In the fresh-run migrant the gills are dominated by large, flask-shaped cells which show some ultrastructural similar...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00221380
更新日期：1976-10-06 00:00:00
abstract：:Fluorescent (aminergic) fibers were demonstrated by the Falck-Hillarp technique in all parts of the neurohypophysis (NH) in the roach (Leuciscus rutilus). The fibers are very thin and few in number in the rostral (RNH) and proximal neurohypophysis (PNH) but slightly more numerous in the NH adjacent to the pars interme...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219959
更新日期：1975-01-01 00:00:00
abstract：:With the gallocyanine technique (Wittkowski, Bock and Franken, 1970) Gomori-positive substances of the infundibulum can be stained for light- and electron-microscopic examination. In various mammalian species, the size of Gomori-positive elementary granules in the outer layer is markedly different from that in the inn...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218495
更新日期：1975-11-19 00:00:00
abstract：:Homeobox genes encode transcription factors that regulate embryonic development programs including organogenesis, axis formation and limb development. Previously, we identified and cloned a mouse double homeobox gene, Duxbl, whose homeodomain exhibits the highest identity (67 %) to human DUX4, a candidate gene of faci...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-014-1974-x
更新日期：2014-11-01 00:00:00
abstract：:In the chironomid Acricotopus lucidus, germ line-soma differentiation becomes evident with the formation of the pole cells and the elimination of the germ line-limited chromosomes (Ks) from the future somatic nuclei of the embryo. Unlike in Drosophila, the early nuclear divisions do not proceed synchronously in A. luc...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410000270
更新日期：2000-11-01 00:00:00
abstract：:Steroid hormones intervene in the structural and functional regulation of neuronal processes during development and thus determine brain differentiation. The effects of estrogens are mediated by two transcription factors, namely estrogen receptor α (ER-α) and estrogen receptor β (ER-β), that regulate the expression of...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-014-2023-5
更新日期：2015-02-01 00:00:00
abstract：:Bovine granulosa cells from 3-7 mm follicles were cultured without anchorage in soft agar/methylcellulose solution for 14 days, with or without 50 ng/ml basic fibroblast growth factor. The granulosa cells divided to form colonies of cells. These were analysed by light and electron microscopy, immunohistochemistry and ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00318878
更新日期：1995-12-01 00:00:00
abstract：:By use of the immunofluorescence technique TSH-, LH- and ACTH-cells were localized in the hypophysis of tadpoles of Xenopus laevis. The first signs of the activity of these cells were observed in early stages of the development, i.e., stage 39 for ACTH, and stage 42 for TSH and LH. ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216218
更新日期：1982-01-01 00:00:00
abstract：:In Streetsia challengeri left and right eyes have fused and become a single cylindrical photoreceptor, which occupies the basal half of a forward directed head projection. This unusual compound eye consists of approximately 2500 ommatidia, which are arranged in such a way that the animal has almost circumferential vis...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00225542
更新日期：1978-01-17 00:00:00
abstract：:alpha-Smooth muscle (alpha SM) actin of endothermic vertebrates is selectively recognized by the monoclonal antibody anti-alpha SM-1. Immunoreactivity to this antibody has been shown to be localized in the NH2-terminal sequence Ac-EEED (Chaponnier et al. 1994). Among terrestrial ectothermic vertebrates, two amphibian ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00417867
更新日期：1995-09-01 00:00:00
abstract：:Expression of heat-shock protein 47 in intact and fibrotic liver and in hepatic constituent cells was investigated in mice. Immunohistochemical study of intact liver and Western blot analysis of the protein from isolated liver cells revealed that stellate cells and smooth muscle cells of interlobular vessels, but not ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050594
更新日期：1996-05-01 00:00:00
abstract：:The chemical nature of the thickened plasma membrane of cornified cells in stratified squamous epithelium was investigated in comparison with that in noncornified epithelium. Localizations of transglutaminase, molecular weight 92,000 daltons, and detection of epidermal cysteine proteinase inhibitor were effected with ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00215516
更新日期：1987-08-01 00:00:00
abstract：:17beta-estradiol (E2) is important for crustacean ovarian development. This study aims to investigate the distribution and change pattern of E2 in the ovary, hepatopancreas, thoracic ganglion and brain ganglion as well as Vg-mRNA expression level during ovarian development of Chinese mitten crab Eriocheir sinensis. Re...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2834-x
更新日期：2018-08-01 00:00:00
abstract：:Nerve growth factor (NGF) induces morphological and physiological changes in cultured pancreatic beta-cells, including the extension of neurite-like processes. This latter effect is potentiated by dibutyryl cAMP (dbcAMP). beta-cells cultured under these conditions maintain their immunoreactivity to insulin and gamma-a...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410100411
更新日期：2001-09-01 00:00:00
abstract：:Two types of horizontal cells, H1 and H2, were classified using the Golgi technique on flat mounts of the retina of the frog. Cell type H1 possesses rather short, thick dendrites; the diameter of its dendritic field ranges from 40-90 micrometers. H2-cell displays long and thin dendrites; the diameter of its dendritic ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00216747
更新日期：1981-01-01 00:00:00
abstract：:Aquaporins (AQPs) are integral membrane proteins that function as channels for the transfer of water and small solutes across membranes. In mammalian cells, 13 isoforms (AQP0-12) have been identified, and these exhibit unique patterns of expression in various cell types and tissues. Among these isoforms, AQP6 is consi...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-007-0558-4
更新日期：2008-04-01 00:00:00
abstract：:Palatal shelf elevation is a crucial process in palate development, with the contribution of various factors. Disturbances in any factor during this process result in cleft palate. Prior to palatal shelf elevation starting from embryonic day 12.5, the Rac1 expression level in the bend region of the mid-palatal shelf p...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-015-2169-9
更新日期：2015-09-01 00:00:00
abstract：:Chemoreception in marine invertebrates mediates a variety of ecologically important behaviors including defense, reproduction, larval settlement and recruitment, and feeding. The sensory pathways that regulate deposit-feeding activity by polychaetes living in sedimentary habitats are of particular interest because suc...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-008-0660-2
更新日期：2008-09-01 00:00:00
abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) and helospectin are two vasoactive intestinal polypeptide (VIP)-related neuropeptides that have recently been demonstrated in the mammalian gut; the aim of this study was to reveal their occurrence and localisation in the gastrointestinal tract, swimbladder, u...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00300227
更新日期：1994-09-01 00:00:00
abstract：:Macrophages are present throughout the anterior pituitary gland. However, the features and function of macrophages in the gland are poorly understood. Recent studies have indicated that there are two main macrophage classes: M1 (classically activated) and M2 (alternatively activated). In this study, we examine whether...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-016-2564-x
更新日期：2017-05-01 00:00:00
abstract：:A quantitative evaluation of putative amino acid neurotransmitters in sea pansy polyps by high-performance liquid chromatography indicates that the taurine content exceeds that of other amino acids by a 100-fold. The cellular source of this taurine was investigated by immunohistochemistry with two polyclonal antisera ...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s004410050800
更新日期：1997-04-01 00:00:00
abstract：:Sex pheromones orient male moths toward conspecific female moths; the presence of visual information modulates this behavior. In the current study, we explore candidate neuronal pathways for the interaction between vision and the locomotor signal for pheromone orientation. We describe the connectivity between visual n...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-018-2892-0
更新日期：2018-12-01 00:00:00
abstract：:An immunohistochemical study for islet amyloid polypeptide (IAPP) was made on the gastrointestinal (GI) tract and pancreas of man and rat, using antisera raised against a synthetic peptide of C-terminal human IAPP (24-37) and a synthetic peptide of rat IAPP (18-37). A large number of IAPP-immunoreactive cells were fou...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00305236
更新日期：1990-12-01 00:00:00
abstract：:Calcitonin gene-related peptide (CGRP) was found extensively in the small intestine of both non-mammalian and mammalian vertebrates using radioimmunoassay and immunocytochemistry. By radioimmunoassay, the levels of CGRP in rats, mice, chickens, bullfrogs and rainbow trout were found to range from 91.5 to 419.1 ng/g ti...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00223142
更新日期：1989-10-01 00:00:00
abstract：:Induction of HIF-1α by oxygen limitation promotes increased phosphorylation and catalytic depression of mitochondrial pyruvate dehydrogenase (PDH) and an enhanced glycolytic poise in cells. Cobalt chloride and desferrioxamine are widely used as mimics for hypoxia because they increase the levels of HIF-1α. We evaluate...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-012-1517-2
更新日期：2013-01-01 00:00:00
abstract：:Because leucokinins stimulate diuresis in some insects, we wished to identify the neurosecretory cells in Manduca sexta that might be a source of leucokinin-like neurohormones. Immunostaining was done at various stages of development, using an antiserum to leucokinin IV. Bilateral pairs of neurosecretory cells in abdo...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00331367
更新日期：1994-12-01 00:00:00
