Metformin-induced encephalopathy: the role of thiamine.

Abstract:

:A case of metformin encephalopathy is presented in a patient on haemodialysis for end-stage diabetic renal failure. The patient presented with frequent falls and clinical signs of Parkinsonism, on a background of recent anorexia and significant weight loss. Magnetic resonance imaging showed bilateral, symmetrical abnormalities centred on the lentiform nuclei. Metformin was withheld and signs and symptoms quickly resolved. We hypothesise that metformin may cause thiamine deficiency in patients with end-stage renal failure resulting in a specific metabolic encephalopathy.

journal_name

Intern Med J

authors

McGarvey C,Franconi C,Prentice D,Bynevelt M

doi

10.1111/imj.13693

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

194-197

issue

2

eissn

1444-0903

issn

1445-5994

journal_volume

48

pub_type

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