Abstract:
:A case of metformin encephalopathy is presented in a patient on haemodialysis for end-stage diabetic renal failure. The patient presented with frequent falls and clinical signs of Parkinsonism, on a background of recent anorexia and significant weight loss. Magnetic resonance imaging showed bilateral, symmetrical abnormalities centred on the lentiform nuclei. Metformin was withheld and signs and symptoms quickly resolved. We hypothesise that metformin may cause thiamine deficiency in patients with end-stage renal failure resulting in a specific metabolic encephalopathy.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
McGarvey C,Franconi C,Prentice D,Bynevelt Mdoi
10.1111/imj.13693subject
Has Abstractpub_date
2018-02-01 00:00:00pages
194-197issue
2eissn
1444-0903issn
1445-5994journal_volume
48pub_type
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