Management of high risk chronic lymphocytic leukaemia (CLL) patients in Australia.

abstract：BACKGROUND/AIM:Although induction chemotherapy comprising high-dose cytarabine (HiDAC) in combination with idarubicin and etoposide or 'ICE' for adult acute myeloid leukaemia (AML) produces a complete remission rate of nearly 80%, gastrointestinal toxicity is significant. Omission of etoposide may produce similar clini...

journal_title：Internal medicine journal

authors： Low M,Lee D,Coutsouvelis J,Patil S,Opat S,Walker P,Schwarer A,Salem H,Avery S,Spencer A,Wei A

更新日期：2013-03-01 00:00:00

abstract：:The phenomenon of addiction is complex, although its expression clinically is relatively straightforward. There is a series of neurophysiological changes that mediate changes in the mesolimbic and mesocortical systems which in turn lead to disturbances in reward mechanisms. These then act to perpetuate the cycle of in...

journal_title：Internal medicine journal

authors： Foy A

更新日期：2007-05-01 00:00:00

abstract：:The Australian National Chronic Obstructive Pulmonary Disease (COPD) guidelines recommend that inhaled corticosteroids (ICS) be reserved for patients with a post-bronchodilator forced expiratory volume in 1 s (FEV1 ) less than 50% predicted and those who experience ≥2 exacerbations in 12 months. In total, 707 COPD pat...

journal_title：Internal medicine journal

authors： Harrison A,Borg B,Thompson B,Hew M,Dabscheck E

更新日期：2017-11-01 00:00:00

abstract：:These consensus guidelines provide recommendations for the safe handling of monoclonal antibodies. Definitive recommendations are given for the minimum safe handling requirements to protect healthcare personnel. The seven recommendations cover: (i) appropriate determinants for evaluating occupational exposure risk; (i...

journal_title：Internal medicine journal

authors： Alexander M,King J,Bajel A,Doecke C,Fox P,Lingaratnam S,Mellor JD,Nicholson L,Roos I,Saunders T,Wilkes J,Zielinski R,Byrne J,MacMillan K,Mollo A,Kirsa S,Green M

更新日期：2014-10-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a prevalent, chronic and heterogeneous endocrine condition, with reproductive, metabolic and psychological features. Insulin resistance and hyperandrogenaemia are the key pathophysiological hormonal abnormalities. Insulin resistance is a significant contributor to the reproductive a...

journal_title：Internal medicine journal

authors： Shorakae S,Boyle J,Teede H

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a common cause of incidental liver test abnormalities. General practitioners (GP) have a key role in identifying people with NAFLD at risk of significant liver disease. Recent specialist guidelines emphasise the use of fibrosis algorithms or serum biomarkers rathe...

journal_title：Internal medicine journal

authors： Patel PJ,Banh X,Horsfall LU,Hayward KL,Hossain F,Johnson T,Stuart KA,Brown NN,Saad N,Clouston A,Irvine KM,Russell AW,Valery PC,Williams S,Powell EE

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Advance care planning (ACP) provides patients with the ability to make their decisions known about how they would like to be treated if they lose capacity. Medical practitioners have a key role to play in providing information on ACP to their patients. This research explores their knowledge and attitudes to ...

journal_title：Internal medicine journal

authors： Cartwright C,Montgomery J,Rhee J,Zwar N,Banbury A

更新日期：2014-03-01 00:00:00

abstract：:It is generally accepted that the prevalence of food allergy has been increasing in recent decades, particularly in westernised countries, yet high-quality evidence that is based on challenge confirmed diagnosis of food allergy to support this assumption is lacking because of the high cost and potential risks associat...

journal_title：Internal medicine journal

authors： Tang ML,Mullins RJ

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) accuracy after neoadjuvant systemic therapy (NST) for breast cancer varies according to hormone receptor (HR), human epidermal growth factor receptor type-2 (HER2) subtype and Ki-67 proliferation index. Whether MRI accuracy varies by genomic signatures is unknown. We examined...

journal_title：Internal medicine journal

authors： Murphy C,Mukaro V,Tobler R,Asher R,Gibbs E,West L,Giuffre B,Baron-Hay S,Khasraw M

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:There are several treatment modalities available for diabetes; however, the effects of the different medications on coronary artery disease are less understood. The purpose of this study was to evaluate the correlation of insulin-sensitizing therapy with the outcome of stress myocardial perfusion testing and...

journal_title：Internal medicine journal

authors： Kapinya K,Nijjar PS,Stanek M,Amanullah A

更新日期：2008-04-01 00:00:00

abstract：:Undiagnosed pheochromocytoma in pregnancy is associated with significant maternal and foetal mortality. Herein we reviewed five cases of pheochromocytoma in pregnancy occurring during late pregnancy. The mean age at presentation was 30.6 years, and the gestational age ranged from 26 to 36 weeks. All patients had eleva...

journal_title：Internal medicine journal

authors： Song Y,Liu J,Li H,Zeng Z,Bian X,Wang S

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia occurring in 2% of the population. It is known that AF increases morbidity and limits quality of life. The CHA2 DS2 VASc score (congestive heart failure/left ventricular dysfunction, hypertension, age ≥75 (doubled), diabetes, stroke (doubled), vascular d...

journal_title：Internal medicine journal

authors： Mlodawska E,Tomaszuk-Kazberuk A,Lopatowska P,Kaminski M,Musial WJ

更新日期：2017-03-01 00:00:00

abstract：:The incidence of tuberculosis in the non-indigenous Australian population is low. However, in this paper we report on three cases of cavitating disease, which seem to be associated with a common illicit drug habit namely smoking marijuana using a makeshift pipe or bong. There was a total of 34 positive contacts of the...

journal_title：Internal medicine journal

authors： Thu K,Hayes M,Miles S,Tierney L,Foy A

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Management of adrenal incidentalomas (AI) is becoming more conservative, based on international data showing a low incidence of functional or malignant lesions. The clinical characteristics of AI in New Zealand are unknown. Therefore, whether the AI guidelines apply to the New Zealand population is also unkn...

journal_title：Internal medicine journal

authors： Goh Z,Phillips I,Hunt PJ,Soule S,Cawood TJ

更新日期：2018-02-01 00:00:00

abstract：:A prospective study of non-invasive ventilation at The Prince Charles Hospital outside of the intensive care unit from March 2015 to March 2016 was performed. Overall 69 patients were included. Acute hypercapnic respiratory failure was the most common indication (n = 59; 85%). 49 (71%) had multifactorial respiratory f...

journal_title：Internal medicine journal

authors： Smith DB,Tay GTP,Hay K,Antony J,Bell B,Kinnear FB,Curtin DL,Douglas J

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Pleural procedures may cause serious complications when incorrectly carried out. There is a need to find effective methods for teaching how to insert a chest drain safely. AIM:To assess the effectiveness of a programme for teaching chest tube insertion using a simulation model (SuperAnnie). METHODS:Groups ...

journal_title：Internal medicine journal

authors： Hutton IA,Kenealy H,Wong C

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:A Resuscitation Plan is a medically authorised order to use or withhold resuscitation interventions. Absence of appropriate resuscitation orders exposes patients to the risk of invasive medical interventions that may be of questionable benefit depending on individual circumstances. AIMS:To describe among ju...

journal_title：Internal medicine journal

authors： Bryant J,Waller A,Pickles R,Hullick C,Price E,White B,Willmott L,Bowman MA,Knight A,Ryall MA,Sanson-Fisher R

更新日期：2020-07-20 00:00:00

abstract：BACKGROUND:Since Hinton first published his observations on the distress of patients dying on a medical ward in 1963, there has been increasing awareness of the palliative care needs in patients who have non malignant diseases. Patients with advanced chronic obstructive pulmonary disease (COPD) are known to have compar...

journal_title：Internal medicine journal

authors： Iupati SP,Ensor BR

更新日期：2016-03-01 00:00:00

abstract：AIM:To prospectively evaluate the efficacy and safety of Selective Internal Radiation (SIR) Spheres (Sirtex Medical, Sydney, NSW, Australia) in patients with unresectable primary or secondary hepatic malignancies. METHODS:We report our experience of SIR sphere therapy at three Australian centres. Patients with previou...

journal_title：Internal medicine journal

authors： Lim L,Gibbs P,Yip D,Shapiro JD,Dowling R,Smith D,Little A,Bailey W,Liechtenstein M

更新日期：2005-04-01 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) has a well-established role in the treatment of haematological malignancies. Stem cells are commonly collected following salvage chemotherapy although there may be advantages in collecting earlier in the disease course. A 'rainy day' harvest (RDH) refers to the collection of...

journal_title：Internal medicine journal

authors： Trotman J,Presgrave P,Kwan Y,Tiley C,Estell J,Watson AM,O'Brien TA,Peters D

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:We presumed that identification of the factors associated with improvement of fatty livers disease (FLD) would support the therapeutic options for FLD. The goal of this study was to clarify what clinical characteristics are associated with biochemical and sonographic improvements in the non-alcoholic populat...

journal_title：Internal medicine journal

authors： Park SH,Kim BI,Kim HJ,Kim H,Kim SH,Park DI,Cho YK,Sung IK,Sohn CI,Jeon WK,Keum DK

更新日期：2005-08-01 00:00:00

abstract：:Laura was unusual. She had always been different and at times difficult. She was born with a genetic disorder, diagnosed as 1p36 deletion syndrome when she was 21 years old. At 23 she suffered her first cardiac arrest at home and entered the hospital system for the first time apart from infancy. After initially appear...

journal_title：Internal medicine journal

authors： Tandy PA

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Population-based studies of the prevalence of all functional gastrointestinal disorders (FGID) using the Rome II criteria are lacking. It is also not certain whether subjects who meet the Rome II criteria for an FGID are different in terms of demographic and psychological characteristics from those subjects ...

journal_title：Internal medicine journal

authors： Boyce PM,Talley NJ,Burke C,Koloski NA

更新日期：2006-01-01 00:00:00

abstract：AIMS:Low molecular weight heparins (LMWH) permit safe and effective treatment of uncomplicated deep venous thrombosis (DVT) at home. The aim of this study was to evaluate the cost minimization, cost shifting and patient satisfaction associated with at-home DVT treatment using the LMWH enoxaparin, compared to standard i...

journal_title：Internal medicine journal

authors： Smith BJ,Weekley JS,Pilotto L,Howe T,Beven R

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:High inflammatory bowel disease (IBD) rates have been reported in Australasia, but no state-wide studies have yet been performed. AIM:This study estimates the 1-year incidence and point prevalence of IBD in the state of Tasmania, Australia. It also reports clinical outcomes after 12 months of diagnosis in a...

journal_title：Internal medicine journal

authors： Bhatia R,Yeoh SW,Vaz K,Studd C,Wilson J,Bell S,Otahal P,Venn A

更新日期：2019-05-01 00:00:00

abstract：:Waldenström macroglobulinaemia (WM) is an indolent B-cell malignancy characterised by the presence of immunoglobulin M (IgM) paraprotein and bone marrow infiltration by clonal small B lymphocytes, plasmacytoid lymphocytes and plasma cells. The symptoms of WM are protean, often follow an asymptomatic phase and may incl...

journal_title：Internal medicine journal

authors： Talaulikar D,Tam CS,Joshua D,Ho JP,Szer J,Quach H,Spencer A,Harrison S,Mollee P,Roberts AW,Horvath N,Lee C,Zannettino A,Brown R,Augustson B,Jaksic W,Gibson J,Kalff A,Johnston A,Trotman J,Kalro A,Grigoriadis G,

更新日期：2017-01-01 00:00:00

abstract：:Significant developments have occurred in the discipline of palliative care in the modern era. This paper shall explore those developments, challenge some widely held misconceptions about the role and daily practice of the discipline, highlight the growing recognition of the role of palliative care in non-malignant di...

journal_title：Internal medicine journal

authors： Brennan F

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Our previous work identified deficiencies in stroke care practices at regional hospitals in comparison to standards suggested by published stroke care guidelines. These deficiencies might be improved by the implementation of clinical pathways. The aim of this study was to assess changes in acute stroke care ...

journal_title：Internal medicine journal

authors： Read SJ,Levy J

更新日期：2006-10-01 00:00:00

abstract：:Severe sepsis is defined as organ dysfunction in the setting of systemic inflammatory response due to infection. With changes in population age, comorbidity and the delivery of medical care, severe sepsis is increasingly common, and can present in every area of the hospital. The major obstacles to improved outcomes in...

journal_title：Internal medicine journal

authors： Huggan PJ

更新日期：2011-01-01 00:00:00

abstract：:ABSTRACT Treatment of invasive fungal infections is increasingly complex. Amphotericin B deoxycholate has long been the mainstay of treatment. However, there has been increasing recognition of both the propensity for nephro-toxicity in haematology, transplant and intensive care patients as well as its adverse impact o...

journal_title：Internal medicine journal

authors： Slavin MA,Szer J,Grigg AP,Roberts AW,Seymour JF,Sasadeusz J,Thursky K,Chen SC,Morrissey CO,Heath CH,Sorrell T

更新日期：2004-04-01 00:00:00