Abstract:
AIM:To prospectively evaluate the efficacy and safety of Selective Internal Radiation (SIR) Spheres (Sirtex Medical, Sydney, NSW, Australia) in patients with unresectable primary or secondary hepatic malignancies. METHODS:We report our experience of SIR sphere therapy at three Australian centres. Patients with previously untreated colorectal cancer (CRC) received concurrent 5FU, other patients with CRC received 5-FU at investigator discretion and all other patients received SIR spheres alone. RESULTS:Forty-six patients were enrolled between January 2002 and June 2003. The majority (32 patients) had metastatic colorectal cancer and five patients had hepatocellular carcinoma. The median age of patients was 64 years (range 46-78 years). Forty-three patients were evaluable for response. There were 12 partial responses, of which 10 were in patients with CRC. The median duration of response for all patients was 8.6 months (range 2-21 months). Overall treatment related toxicity was acceptable. Significant late toxicity included four cases of severe gastric ulceration, despite standard work-up and treatment by experienced interventional radiologists. CONCLUSION:In this series of patients, treatment with SIR-spheres has demonstrated modest activity, mostly observed in patients with CRC. Toxicity was substantial in a small number of patients.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Lim L,Gibbs P,Yip D,Shapiro JD,Dowling R,Smith D,Little A,Bailey W,Liechtenstein Mdoi
10.1111/j.1445-5994.2005.00789.xkeywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
222-7issue
4eissn
1444-0903issn
1445-5994pii
IMJ789journal_volume
35pub_type
临床试验,杂志文章,多中心研究abstract:BACKGROUND:Our previous work identified deficiencies in stroke care practices at regional hospitals in comparison to standards suggested by published stroke care guidelines. These deficiencies might be improved by the implementation of clinical pathways. The aim of this study was to assess changes in acute stroke care ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2006.01147.x
更新日期:2006-10-01 00:00:00
abstract::Staphylococcal infections are a common and significant clinical problem in medical practice. Most strains of Staphylococcus aureus are now resistant to penicillin, and methicillin-resistant strains of S. aureus (MRSA) are common in hospitals and are emerging in the community. Penicillinase-resistant penicillins (flucl...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1444-0903.2005.00976.x
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Many patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have type 2 respiratory failure (T2RF). Often arterial blood gases are not performed and correlation with venous blood gases (VBG) is controversial. The venous pH and bicarbonate (HCO3 ) are useful, but VBG pCO2 (PvCO2 )...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14186
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:The Northern Territory (NT) has a long history of heavy alcohol consumption with a correspondingly high attributable morbidity and mortality. AIMS:We aimed to describe the number of admissions to Intensive Care associated with alcohol misuse. METHODS:Prospective case-control study including all admissions ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15212
更新日期:2021-01-19 00:00:00
abstract::Here we report the case of a 69-year-old Chinese Han woman who presented with liver cirrhosis, diabetes mellitus, skin hyperpigmentation, hyperferritinaemia and high transferrin saturation. Subsequent genetic analyses identified a novel heterozygous mutation (p.Cys326Phe) in the SLC40A1 gene. This is the first report ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12764
更新日期:2015-06-01 00:00:00
abstract::Australian internal medicine trainees undergo intensive training in preparation for the Royal Australasian College of Physicians (RACP) clinical examination. Trainees preparing for the 2013 RACP clinical examination assessed the jugular venous pressure (JVP) of patients, with central venous pressure monitoring in the ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13178
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:The clinical significance of extreme hyperferritinaemia has come under scrutiny with the increasing recognition of haemophagocytic lymphohistiocytosis (HLH) in adults. Most studies of hyperferritinaemia have focused on serum ferritin greater than 1000 μg/L, often in ambulatory patients. The conditions associ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12768
更新日期:2015-08-01 00:00:00
abstract::Medical goddesses and gods invoked in the Hippocratic Oath were called on in times of pandemics along with Greek physicians such as Galen of Pergamum. Ancient Greek and Roman coinage provide insights into the coexisting religious and rational approaches to medicine rooted in Classical Antiquity, portraying medical sym...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15111
更新日期:2020-12-01 00:00:00
abstract::The Australian Clinical Guidelines for Stroke Management 2010 represents an update of the Clinical Guidelines for Stroke Rehabilitation and Recovery (2005) and the Clinical Guidelines for Acute Stroke Management (2007). For the first time, they cover the whole spectrum of stroke, from public awareness and prehospital ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2012.02774.x
更新日期:2012-05-01 00:00:00
abstract::This pilot study in a prospective cohort of 20 cryptogenic stroke patients showed that a significant proportion has paroxysmal atrial fibrillation undetected by 24-h Holter monitoring. However, longer monitoring with 28-day Holter was poorly tolerated and still insufficiently sensitive for paroxysmal atrial fibrillati...
journal_title:Internal medicine journal
pub_type: 临床试验,杂志文章
doi:10.1111/imj.12410
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:There are several treatment modalities available for diabetes; however, the effects of the different medications on coronary artery disease are less understood. The purpose of this study was to evaluate the correlation of insulin-sensitizing therapy with the outcome of stress myocardial perfusion testing and...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01480.x
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Teaching, mentoring and supervision (TMS) are fundamental skills with a specific commitment within the Royal Australasian College of Physicians (RACP) professional practice framework. The new basic training standards include 'use of appropriate educational techniques to facilitate the learning of peers, juni...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14935
更新日期:2020-06-08 00:00:00
abstract::Autoimmune inflammatory rheumatic diseases (AIIRD), such as rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis are often complicated by infection, which results in significant morbidity and mortality. The increased risk of infection is probably due to a combination of immunosuppressive effects of the...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.13371
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The comparative effectiveness of biologic treatment regimens in a real world Australian population is unknown. AIM:To assess the effectiveness of biological disease-modifying anti-rheumatic drugs (bDMARD) as monotherapy or in combination with methotrexate and/or other conventional DMARD (cDMARD) for the tre...
journal_title:Internal medicine journal
pub_type: 杂志文章,多中心研究
doi:10.1111/imj.14028
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:High inflammatory bowel disease (IBD) rates have been reported in Australasia, but no state-wide studies have yet been performed. AIM:This study estimates the 1-year incidence and point prevalence of IBD in the state of Tasmania, Australia. It also reports clinical outcomes after 12 months of diagnosis in a...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14111
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:There is no mechanism in place for monitoring or quality improvement of cancer multidisciplinary meetings (MDM) in Australia. AIM:To develop a peer-review process for quality improvement of MDM. METHODS:This project involved three phases: (i) development of a draft peer-review framework, supporting documen...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.13374
更新日期:2017-05-01 00:00:00
abstract::Radical market-oriented health reforms in New Zealand in the early 1990s failed to deliver key financial targets, resulted in unnecessary patient deaths, adversely affected public healthcare services, induced serious tensions between clinicians and managers and encouraged a predisposition to private healthcare. A more...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14903
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Acute poisoning accounts for a significant proportion of the total burden of disease worldwide. While the rate of poisoning fatalities in New Zealand is comparable to other industrialised countries, demographic trends in incidence, particularly including socio-economic indicators and substances involved, are...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12364
更新日期:2014-03-01 00:00:00
abstract::Conventional teaching on the mechanisms and treatment of spontaneous pneumothorax is either obviously wrong or based on a misunderstanding of the natural history of the condition. Spontaneous pneumothorax is a generally benign, self-limiting condition where conservative management should be considered. If intervention...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2009.02155.x
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Advanced training in gastroenterology currently consists of 2 years of core training and 1 elective (non-core) year. We surveyed gastroenterologists 2-7 years following completion of training to determine the strengths and weaknesses of their training. METHODS:All gastroenterologists were invited to partici...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2012.02757.x
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:There is no valid cardiovascular disease (CVD) risk prediction equation for Australians with diabetes. The aim of this study is to develop and validate a multivariate risk function for 5-year cardiovascular risk prediction in Australian type 2 diabetes patients. METHODS:The Fremantle Diabetes Study is a com...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.01958.x
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:It is recommended that blood pressure should be measured on a bare upper arm with an appropriately sized cuff. However, in practice, it is more convenient to measure blood pressure on sleeved arms. AIMS:We aim to examine the effect of sleeved arms on the accuracy of blood pressure measurement. METHODS:Pati...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15071
更新日期:2020-09-25 00:00:00
abstract::Clinician-performed chest ultrasound is rapidly entering clinical practice in the fields of intensive care, respiratory medicine and acute medicine. Ultrasound is clearly useful in the diagnosis and characterisation of pleural diseases. It is also critical in improving the safety of pleural interventions. More recentl...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2012.02816.x
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Effective clinical handover has always been integral to delivering safe, high-quality care in medical wards. AIM:As handover activity increases in importance we wanted to explore the experience of physicians and trainee doctors. There is little research on internal medicine handover with even less based on ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14142
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The use of contrast agents during coronary intervention can result in nephropathy, particularly in patients with renal dysfunction. We aimed to determine whether the use of iso-osmolar iodixanol is less nephrotoxic than that of low-osmolar iopromide when patients are adequately prehydrated and have received ...
journal_title:Internal medicine journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1445-5994.2008.01675.x
更新日期:2009-01-01 00:00:00
abstract::Interaction between doctors and the pharmaceutical industry is long-standing and ingrained in modern practice. Doctors-in-training are at a vulnerable stage of their careers, both in requiring knowledge and forming lasting relationships. There is evidence that limiting contact between industry and junior doctors has a...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12855
更新日期:2015-10-01 00:00:00
abstract::ABSTRACT Treatment of invasive fungal infections is increasingly complex. Amphotericin B deoxycholate has long been the mainstay of treatment. However, there has been increasing recognition of both the propensity for nephro-toxicity in haematology, transplant and intensive care patients as well as its adverse impact o...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1444-0903.2004.00541.x
更新日期:2004-04-01 00:00:00
abstract::The Queensland branch of the Royal Australasian College of Physicians (RACP) commissioned this study to update their workforce profile and examine rural practice. The present investigation aimed to describe characteristics of Queensland physicians and determine the influence of childhood and training locations on curr...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13156
更新日期:2016-08-01 00:00:00
abstract::The annual Leonard Ball Orations illustrate changing perspectives in Australia over 30 years on medical and social effects of misuse of alcohol and other substances. The first oration, in 1968, examined causal factors in the context of 'agent', 'purveyor' and 'host' and provided themes for subsequent orators. In regar...
journal_title:Internal medicine journal
pub_type: 历史文章,杂志文章
doi:10.1046/j.1445-5994.2001.00068.x
更新日期:2001-08-01 00:00:00
abstract::Transfusion-related acute lung injury (TRALI) is a leading cause of transfusion related morbidity and mortality. Current concepts regarding the pathogenesis of this disorder imply a "two-hit" model in which neutrophils are sequestered in the pulmonary capillary bed, and subsequently activated by substances in the tran...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2010.02366.x
更新日期:2011-08-01 00:00:00