Abstract:
:ABSTRACT Treatment of invasive fungal infections is increasingly complex. Amphotericin B deoxycholate has long been the mainstay of treatment. However, there has been increasing recognition of both the propensity for nephro-toxicity in haematology, transplant and intensive care patients as well as its adverse impact on morbidity and mortality. This has coincided with the availabilty of newer, and in certain settings, more effective antifungal agents. Although the newer agents clearly cause less nephrotoxicity than amphotericin B, drug interactions, hepatic effects and unique side-effects need to be considered. The spectrum of the newer triazoles and echinocandins varies, highlighting the importance of accurate identification of the causative organism where possible. Consensus Australian guidelines have been developed to assist clinicians with treatment choices by reviewing the current evidence for the efficacy, the toxicity and the cost of these agents.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Slavin MA,Szer J,Grigg AP,Roberts AW,Seymour JF,Sasadeusz J,Thursky K,Chen SC,Morrissey CO,Heath CH,Sorrell Tdoi
10.1111/j.1444-0903.2004.00541.xkeywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
192-200issue
4eissn
1444-0903issn
1445-5994pii
IMJ541journal_volume
34pub_type
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