Guidelines for the use of antifungal agents in the treatment of invasive Candida and mould infections.

Abstract:

:ABSTRACT Treatment of invasive fungal infections is increasingly complex. Amphotericin B deoxycholate has long been the mainstay of treatment. However, there has been increasing recognition of both the propensity for nephro-toxicity in haematology, transplant and intensive care patients as well as its adverse impact on morbidity and mortality. This has coincided with the availabilty of newer, and in certain settings, more effective antifungal agents. Although the newer agents clearly cause less nephrotoxicity than amphotericin B, drug interactions, hepatic effects and unique side-effects need to be considered. The spectrum of the newer triazoles and echinocandins varies, highlighting the importance of accurate identification of the causative organism where possible. Consensus Australian guidelines have been developed to assist clinicians with treatment choices by reviewing the current evidence for the efficacy, the toxicity and the cost of these agents.

journal_name

Intern Med J

authors

Slavin MA,Szer J,Grigg AP,Roberts AW,Seymour JF,Sasadeusz J,Thursky K,Chen SC,Morrissey CO,Heath CH,Sorrell T

doi

10.1111/j.1444-0903.2004.00541.x

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

192-200

issue

4

eissn

1444-0903

issn

1445-5994

pii

IMJ541

journal_volume

34

pub_type

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