Abstract:
:These consensus guidelines provide recommendations for the safe handling of monoclonal antibodies. Definitive recommendations are given for the minimum safe handling requirements to protect healthcare personnel. The seven recommendations cover: (i) appropriate determinants for evaluating occupational exposure risk; (ii) occupational risk level compared with other hazardous and non-hazardous drugs; (iii) stratification of risk based on healthcare personnel factors; (iv) waste products; (v) interventions and safeguards; (vi) operational and clinical factors and (vii) handling recommendations. The seventh recommendation includes a risk assessment model and flow chart for institutions to consider and evaluate clinical and operational factors unique to individual healthcare services. These guidelines specifically evaluated monoclonal antibodies used in the Australian cancer clinical practice setting; however, the principles may be applicable to monoclonal antibodies used in non-cancer settings. The guidelines are only applicable to parenterally administered agents.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Alexander M,King J,Bajel A,Doecke C,Fox P,Lingaratnam S,Mellor JD,Nicholson L,Roos I,Saunders T,Wilkes J,Zielinski R,Byrne J,MacMillan K,Mollo A,Kirsa S,Green Mdoi
10.1111/imj.12564subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1018-26issue
10eissn
1444-0903issn
1445-5994journal_volume
44pub_type
杂志文章,实务指引abstract::Radical market-oriented health reforms in New Zealand in the early 1990s failed to deliver key financial targets, resulted in unnecessary patient deaths, adversely affected public healthcare services, induced serious tensions between clinicians and managers and encouraged a predisposition to private healthcare. A more...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14903
更新日期:2020-07-01 00:00:00
abstract:AIM:Premature discontinuation of antiplatelet therapy is an independent predictor of late stent thrombosis. We sought to determine the prevalence and predictors of premature discontinuation of antiplatelet therapy after drug-eluting stent implantation among patients in Asia. METHODS:A total of 207 consecutive patients...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.02104.x
更新日期:2011-08-01 00:00:00
abstract::Parathyroid hormone (PTH) is the predominant regulator of calcium/phosphate homeostasis in the human body. Beside this classical function, preclinical and clinical studies indicated a relevant role for PTH in mobilisation of bone marrow-derived cells into peripheral blood. In addition, recombinant PTH (teriparatide) w...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12830
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:There is no valid cardiovascular disease (CVD) risk prediction equation for Australians with diabetes. The aim of this study is to develop and validate a multivariate risk function for 5-year cardiovascular risk prediction in Australian type 2 diabetes patients. METHODS:The Fremantle Diabetes Study is a com...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.01958.x
更新日期:2010-04-01 00:00:00
abstract::Leprosy remains an important global health concern, but little has been published about its diagnosis and management in developed settings. It has been postulated that delay in diagnosis is common in developed settings. We reviewed all the cases of leprosy seen at a major tertiary referral centre between 1999 and 2013...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12638
更新日期:2015-01-01 00:00:00
abstract::The Queensland branch of the Royal Australasian College of Physicians (RACP) commissioned this study to update their workforce profile and examine rural practice. The present investigation aimed to describe characteristics of Queensland physicians and determine the influence of childhood and training locations on curr...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13156
更新日期:2016-08-01 00:00:00
abstract::To improve organ donation processes and outcomes, many Australian hospitals have introduced donation after cardiac death (DCD) following the 2010 publication of the National Protocol for DCD. As emergency clinicians play a significant role in identifying potential DCD donors, it is critical to assess their support and...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12181
更新日期:2013-07-01 00:00:00
abstract::A prospective study of non-invasive ventilation at The Prince Charles Hospital outside of the intensive care unit from March 2015 to March 2016 was performed. Overall 69 patients were included. Acute hypercapnic respiratory failure was the most common indication (n = 59; 85%). 49 (71%) had multifactorial respiratory f...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13632
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Anticoagulants are recommended to prevent cardioembolic stroke in most patients with atrial fibrillation (AF). Management errors with anticoagulation and use of aspirin instead of anticoagulants have been documented worldwide, especially with vitamin K antagonists. We assessed the rate of anticoagul...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15167
更新日期:2020-12-21 00:00:00
abstract:BACKGROUND:The thiopurines azathioprine and 6-mercaptopurine are recommended for maintenance of remission in inflammatory bowel disease (IBD). Measurement of concentrations of the metabolites 6-thioguanine nucleotide and 6-methylmercaptopurine helps delineate interindividual variation in metabolism that may underlie va...
journal_title:Internal medicine journal
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1445-5994.2012.02936.x
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Where proven cancer therapies remain unfunded, patients are faced with difficult decisions regarding personally covering some or all of the treatment cost. Clinical trials provide an alternative form of access to unfunded drugs. AIMS:To examine the patient population and utilisation of the colorectal cancer...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2012.02750.x
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) represent the leading causes of death in systemic sclerosis (SSc). Screening for these complications has assumed greater importance, but is not universal. The aim of this study is to determine the self-reported screening, diagnosis and...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.01990.x
更新日期:2010-07-01 00:00:00
abstract:AIMS:To evaluate the effectiveness of a new locality-based integrated diabetes care service for people with Type 2 diabetes in an inner regional area. METHODS:A quasi-experimental evaluation comparing baseline and follow up clinical data collected from general practices and specialist services participating in an inte...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15211
更新日期:2021-01-20 00:00:00
abstract::The annual Leonard Ball Orations illustrate changing perspectives in Australia over 30 years on medical and social effects of misuse of alcohol and other substances. The first oration, in 1968, examined causal factors in the context of 'agent', 'purveyor' and 'host' and provided themes for subsequent orators. In regar...
journal_title:Internal medicine journal
pub_type: 历史文章,杂志文章
doi:10.1046/j.1445-5994.2001.00068.x
更新日期:2001-08-01 00:00:00
abstract::Doctor-patient language discordance has been shown to lead to worse clinical outcomes. In this study of patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction at an Australian health service, we demonstrated that limited English proficiency (LEP) is an independent predict...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13751
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND/AIM:Little is known about exposures to low radiation doses in the first trimester of pregnancy and deterministic adverse effects in the offspring, and risks are extrapolated from catastrophic events or from exposures to radiotherapy. The study aimed to assess the foetal and neonatal outcomes of pregnant wome...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12043
更新日期:2013-05-01 00:00:00
abstract::It is generally accepted that the prevalence of food allergy has been increasing in recent decades, particularly in westernised countries, yet high-quality evidence that is based on challenge confirmed diagnosis of food allergy to support this assumption is lacking because of the high cost and potential risks associat...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13362
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Medical school and resident training programmes offer different learning opportunities and outcomes. The aim of the study was to assess medical student and intern experience in common clinical procedures. METHODS:Interns employed in a metropolitan teaching hospital from 2000 to 2004 completed a survey of ex...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.01699.x
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The current results on the diagnostic accuracy of multidetector computed tomography (MDCT) in the detection of left atrial/left atrial appendage (LA/LAA) thrombus are conflicting. AIM:The aim of the present study was to determine the diagnostic accuracy of MDCT in LA/LAA thrombus with meta-ana...
journal_title:Internal medicine journal
pub_type: 杂志文章,meta分析
doi:10.1111/j.1445-5994.2012.02932.x
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Extreme heat is a public health priority in Australia with the health effects of cold poorly studied. A record-breaking cold winter prompted an institutional investigation into the epidemiology and outcomes of hypothermic presentations. AIMS:To describe the clinical and epidemiological characteristics of hy...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14308
更新日期:2020-01-01 00:00:00
abstract:AIMS:Our primary aim was to determine the rate of overseas travel in immunocompromised individuals attending appropriate clinics at an Australian tertiary care hospital. We also aimed to characterise health-seeking behaviour prior to travel and investigated sources of pre-travel advice, compared travel patterns and act...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12753
更新日期:2015-06-01 00:00:00
abstract::Diabetes mellitus (DM) has been found to be associated with cardiovascular disease. The goal of this study is to evaluate the prevalence of asthma in patients with type II DM after adjusting for other comorbid conditions. We used patient treatment files of inpatients' admissions containing discharge diagnosis (Classif...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.01976.x
更新日期:2009-10-01 00:00:00
abstract::Undiagnosed pheochromocytoma in pregnancy is associated with significant maternal and foetal mortality. Herein we reviewed five cases of pheochromocytoma in pregnancy occurring during late pregnancy. The mean age at presentation was 30.6 years, and the gestational age ranged from 26 to 36 weeks. All patients had eleva...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12118
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND: Several cellular pathways are implicated in the pathogenesis of pulmonary arterial hypertension (PAH) and attempts to arrest disease progression with a single drug would not be expected to succeed in the medium term. In clinical practice, combination therapy is often used in patients deteriorating on monot...
journal_title:Internal medicine journal
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1445-5994.2010.02403.x
更新日期:2011-03-01 00:00:00
abstract::Perhexiline is a prophylactic anti-anginal agent that ameliorates the metabolic basis for myocardial ischaemia and is increasingly used in the management of acute coronary syndromes. No intravenous preparation is available and usual oral loading regimens require 2-3 days to achieve therapeutic drug levels. Two patient...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2004.00624.x
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Frailty is common among acute hospital patients and might adversely affect recovery from inpatient cardiac arrest. AIM:To assess the relationship between hospital admission characteristics, including frailty, and discharge outcome after in-hospital cardiac arrest. METHODS:Prospectively collected data were ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14159
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:While treatment guidelines have been developed to guide the management of Staphylococcus aureus bacteraemia, there is a need to validate these guidelines in different clinical settings and to relate the effect of compliance to clinical outcome. AIMS:To assess the impact of adherence to treatment guidelines ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2001.00205.x
更新日期:2002-05-01 00:00:00
abstract::Advanced heart failure represents a small proportion of patients with heart failure that possess high-risk features associated with high hospital readmission rates, significant functional impairment and mortality. Identification of those who have progressed to, or are near a state of advanced heart failure should prom...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12817
更新日期:2016-05-01 00:00:00
abstract::Common peroneal neuropathy (CPN) may develop unexpectedly in patients with underlying cancer. To clarify the underlying pathophysiology, clinical and neurophysiological data were prospectively collected from 10 oncology clinic patients referred for neurological assessment after the onset of foot weakness. In all patie...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2012.02836.x
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Magnetic resonance angiography (MRA) of renal vessels correlates well with conventional angiography (CA) and enables non-invasive assessment of renal vessels without nephrotoxic contrast. AIMS:We aimed to identify the referral source and nature of the patient group undergoing renal MRA, and the impact of th...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2003.00336.x
更新日期:2003-03-01 00:00:00