Circuit breakers for addiction.

Abstract:

:The phenomenon of addiction is complex, although its expression clinically is relatively straightforward. There is a series of neurophysiological changes that mediate changes in the mesolimbic and mesocortical systems which in turn lead to disturbances in reward mechanisms. These then act to perpetuate the cycle of intoxication and reinforcement, withdrawal, craving and compulsive use. As our understanding of the pathophysiology of this process has improved, new pharmacological agents have been developed with the potential to moderate or even reverse it. This article briefly reviews the treatment of addiction with particular reference to emerging pharmaceutical agents.

journal_name

Intern Med J

authors

Foy A

doi

10.1111/j.1445-5994.2007.01350.x

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

320-5

issue

5

eissn

1444-0903

issn

1445-5994

pii

IMJ1350

journal_volume

37

pub_type

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