Abstract:
:A 22-year-old woman presented with methanol toxicity manifesting as headache, reduced conscious state and visual change after consuming home-made grappa. She progressed to a coma with fixed mydriasis and severe acidaemia (pH 6.55). She was treated with empirical antidote administration (intravenous ethanol) and enhanced elimination through haemodialysis. She survived despite her delayed presentation but developed significant neurological sequelae, including visual impairment. We provide an overview of key elements of diagnosis and recent updates in treatment recommendations.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Holt NR,Nickson CPdoi
10.1111/imj.13725subject
Has Abstractpub_date
2018-03-01 00:00:00pages
335-339issue
3eissn
1444-0903issn
1445-5994journal_volume
48pub_type
杂志文章abstract:BACKGROUND:Increasing numbers of patients receiving new oral anticoagulants (NOAC) are undergoing elective surgery. The extent to which perioperative interruption of NOAC therapy and use of bridging heparin are concordant with best evidence is uncertain. AIMS:To determine: (i) concordance of NOAC and bridging heparin ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13513
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Pulmonary embolism (PE) is associated with significant morbidity and mortality. PE is a heterogeneous entity that causes a wide variety of clinical presentations, making it imperative to establish which clinical symptoms, signs and biomarkers can influence the pretest probability of PE to aid clinicians and ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13596
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIM:Little is known about exposures to low radiation doses in the first trimester of pregnancy and deterministic adverse effects in the offspring, and risks are extrapolated from catastrophic events or from exposures to radiotherapy. The study aimed to assess the foetal and neonatal outcomes of pregnant wome...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12043
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Unrelated umbilical cord blood has emerged as an alternative stem cell source for allogeneic transplantation for patients with haematological malignancies, but in adults is limited by the low number of stem cells present in banked cord blood units. We report our experience with double cord blood transplants ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2008.01825.x
更新日期:2009-11-01 00:00:00
abstract::The enthusiasm for evidence-based medicine (EBM) has not been accompanied by the same success in bridging the gap between theory and practice. This paper advances the hypothesis that the phenomenon psychologists call hypocognition may hinder the development of EBM. People tend to respond to frames rather than to facts...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.02086.x
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Asthma is associated with fixed airflow obstruction and an increased risk of death. The aim of this study was to relate asthma mortality and airflow obstruction to severity of asthma in a cohort of patients with chronic asthma studied over a 17-year period. METHODS:In 1980, asthma severity based on symptoms...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2006.01214.x
更新日期:2006-12-01 00:00:00
abstract::The use of tissue-type plasminogen activator (t-PA) in ischaemic stroke outside of experienced stroke centres remains controversial. The aim of this study was to present the initial experience with t-PA in patients with ischaemic stroke at an institution with no prior experience in i.v. stroke thrombolysis and to comp...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2006.01127.x
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Our previous work identified deficiencies in stroke care practices at regional hospitals in comparison to standards suggested by published stroke care guidelines. These deficiencies might be improved by the implementation of clinical pathways. The aim of this study was to assess changes in acute stroke care ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2006.01147.x
更新日期:2006-10-01 00:00:00
abstract::The prevalence of Helicobacter pylori in Western societies has rapidly declined, as reflected by the consistent decline in peptic ulcer disease. Nevertheless, there remains a cohort of the elderly population with a high prevalence of H. pylori infection. While the benefits of H. pylori eradication for H. pylori-associ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2002.00275.x
更新日期:2002-09-01 00:00:00
abstract::Vancomycin remains a clinically useful antibiotic despite the advent of several alternative drugs. Optimising vancomycin therapy with therapeutic drug monitoring is widely recommended. The aim of therapeutic drug monitoring is to help the clinician to achieve target pharmacodynamic parameters in the case of vancomycin...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12036
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Early involvement of palliative care and advance care planning improves quality of life outcomes and survival for patients with advanced lung cancer, however there are barriers to implementation. AIMS AND METHODS:A single-centre prospective audit reviewing "Goals of Care" (GOC) form completion and palliativ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14817
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Advanced physician training in clinical pharmacology lacks a continuing education programme. There is a need for continuing medical education but how to introduce and develop education remains unclear. AIMS:The primary aim was to develop and implement a peer-led, web-based multiple choice question approach ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14663
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Magnetic resonance angiography (MRA) of renal vessels correlates well with conventional angiography (CA) and enables non-invasive assessment of renal vessels without nephrotoxic contrast. AIMS:We aimed to identify the referral source and nature of the patient group undergoing renal MRA, and the impact of th...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2003.00336.x
更新日期:2003-03-01 00:00:00
abstract::Undiagnosed pheochromocytoma in pregnancy is associated with significant maternal and foetal mortality. Herein we reviewed five cases of pheochromocytoma in pregnancy occurring during late pregnancy. The mean age at presentation was 30.6 years, and the gestational age ranged from 26 to 36 weeks. All patients had eleva...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12118
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Acute poisoning accounts for a significant proportion of the total burden of disease worldwide. While the rate of poisoning fatalities in New Zealand is comparable to other industrialised countries, demographic trends in incidence, particularly including socio-economic indicators and substances involved, are...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12364
更新日期:2014-03-01 00:00:00
abstract:AIM:To explore and detail clinical experiences of dabigatran, a novel anticoagulant, after it became available in New Zealand in July 2011. METHODS:A cohort of patients was recruited from Hutt Hospital and the two largest primary care practices in the Hutt Valley region. They were included if they took at least one do...
journal_title:Internal medicine journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/imj.12370
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Stroke neurologists, vascular surgeons, interventional neuroradiologists and interventional cardiologists have embraced carotid angioplasty and stenting (CAS) because of potential advantages over carotid endarterectomy (CEA). At Austin Health, a multidisciplinary neuro-interventional group was formed to stan...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2010.02285.x
更新日期:2011-11-01 00:00:00
abstract::Lymphangioleiomyomatosis (LAM) is a rare disease affecting women, classically involving the lungs. However, extrapulmonary manifestations also occur, including renal angiomyolipomas, retroperitoneal lymphangioleiomyomas and extrathoracic lymphadenopathy. The lung disease is hormone-responsive, but no information exist...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2011.02593.x
更新日期:2011-12-01 00:00:00
abstract::This paper examines the differences between clinical and public health ethics and provides several examples of contemporary public health challenges that pose ethical questions. The relations among ethics, rights and obligations are explored, because public health philosophers propose these as different ways for publi...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2004.00643.x
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Trends in the incidence of acute myocardial infarction (AMI) provide important information for healthcare providers and can allow for accurate planning of future health needs and targeted interventions in areas with an excess burden of cardiovascular disease. AIM:To investigate the regional variations in AM...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13399
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Anticoagulants are recommended to prevent cardioembolic stroke in most patients with atrial fibrillation (AF). Management errors with anticoagulation and use of aspirin instead of anticoagulants have been documented worldwide, especially with vitamin K antagonists. We assessed the rate of anticoagul...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15167
更新日期:2020-12-21 00:00:00
abstract::A patient with pulmonary arterial hypertension secondary to systemic sclerosis was successfully treated with sitaxentan prior to its worldwide withdrawal (because of hepatotoxicity concerns), but then ironically experienced acute hepatic dysfunction during substitute bosentan therapy, and was eventually stabilised on ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12007
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:While medications may prolong life and prevent morbidity in older people, adverse effects of polypharmacy are increasingly recognised. As patients age and become frail, prescribing may be expected to focus more on symptom control and minimise potentially harmful preventive medication use that confer little b...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13526
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:There are several treatment modalities available for diabetes; however, the effects of the different medications on coronary artery disease are less understood. The purpose of this study was to evaluate the correlation of insulin-sensitizing therapy with the outcome of stress myocardial perfusion testing and...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01480.x
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Glomerular M-type phospholipase A2 receptor (PLA2 R) is important for diagnosing idiopathic membranous nephropathy (IMN). The relation between glomerular PLA2 R expression and response to treatment remains to be explored. AIMS:We conducted the study to explore the positive rate and clinical significance of ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13233
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Quick Sepsis-related Organ Failure Assessment (qSOFA) is recommended for use by the most recent international sepsis definition taskforce to identify suspected sepsis in patients outside the Intensive Care Unit (ICU) at risk of adverse outcomes. Evidence of its comparative effectiveness with existing sepsis ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14746
更新日期:2020-01-06 00:00:00
abstract::To improve organ donation processes and outcomes, many Australian hospitals have introduced donation after cardiac death (DCD) following the 2010 publication of the National Protocol for DCD. As emergency clinicians play a significant role in identifying potential DCD donors, it is critical to assess their support and...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12181
更新日期:2013-07-01 00:00:00
abstract::The antibiotic optimisation imperative is now ubiquitous, with national policy frameworks in Organisation for Economic Co-operation and Development (OECD) countries incorporating the requirement for antimicrobial stewardship within healthcare services. Yet in practice, the optimisation agenda often raises complex ethi...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14200
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The relationship between serum triglycerides (TG) level and the risk of coronary heart disease (CHD) mortality remains controversial. AIMS:To evaluate whether TG level is a risk factor for CHD in elderly people from general population, and to look for interactions between TG and other risk factors. METHODS...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2005.00940.x
更新日期:2005-10-01 00:00:00
abstract::We report the first published case of aggressive diffuse large B-cell (non-Hodgkin) lymphoma in a 35-year-old pregnant woman who had Crohn disease and was taking long-term thiopurine therapy: the patient developed placental insufficiency, and there was intrauterine fetal death. ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12957
更新日期:2016-01-01 00:00:00