Utility of immunohistochemistry for mismatch repair proteins on colorectal polyps in the familial cancer clinic.

abstract：BACKGROUND:Neutropenic fever is a frequently encountered complication when caring for cancer patients and can lead to intensive care admission, with high mortality rates in those patients who require invasive mechanical ventilation (IMV). Although hospital survival in this population has improved, long-term outcomes of...

journal_title：Internal medicine journal

authors： Mackintosh D,Way M,Reade MC,Dhanani J

更新日期：2020-05-01 00:00:00

abstract：:The mortality rate post admission to hospital after successful resuscitation from out-of-hospital cardiac arrest is high, with significant variation between regions and individual institutions. While prehospital factors such as age, bystander cardiopulmonary resuscitation and total cardiac arrest time are known to inf...

journal_title：Internal medicine journal

authors： Stub D,Bernard S,Smith K,Bray JE,Cameron P,Duffy SJ,Kaye DM

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Bronchial thermoplasty (BT) is an approved bronchoscopic intervention for the treatment of severe asthma. However, limited published experience exists outside of clinical trials regarding patient selection and outcomes achieved. AIMS:To evaluate the effectiveness and safety of BT in patients with severe ast...

journal_title：Internal medicine journal

authors： Langton D,Sha J,Ing A,Fielding D,Wood E

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The highest healthcare expenditures occur towards the end of life. Costs relate to hospital admissions and investigations to diagnose, prognosticate and direct treatment. AIMS:AnAustralian study to compare the cost of investigations in the last 72 h of life between an inpatient palliative care unit (PCU) an...

journal_title：Internal medicine journal

authors： Gogna G,Broadbent A,Baade I

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Secondary prevention of ischaemic stroke (IS) and transient ischaemic attack (TIA) mandates identification and treatment of multiple metabolic risk factors. The aim was to determine the prevalence of abnormal glycaemia, hypertension and dyslipidaemia in patients presenting to an Acute Stroke Unit of a tertia...

journal_title：Internal medicine journal

authors： Scott DP,Greenfield JR,Bramah V,Alford J,Bennett C,Markus R,Campbell LV

更新日期：2010-04-01 00:00:00

abstract：:5-aminosalicylates (5-ASA) remain an important strategy in the induction and maintenance of remission of inflammatory bowel diseases especially in ulcerative colitis. The prototypical drug of this class, sulfasalazine is generally well tolerated with severe hypersensitivity reactions and hepatotoxicity also described ...

journal_title：Internal medicine journal

authors： Kong LM,Fok KC,Tsui A,Qian C,Fisher L

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) accuracy after neoadjuvant systemic therapy (NST) for breast cancer varies according to hormone receptor (HR), human epidermal growth factor receptor type-2 (HER2) subtype and Ki-67 proliferation index. Whether MRI accuracy varies by genomic signatures is unknown. We examined...

journal_title：Internal medicine journal

authors： Murphy C,Mukaro V,Tobler R,Asher R,Gibbs E,West L,Giuffre B,Baron-Hay S,Khasraw M

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Peptic ulcer disease risk factors have changed, as has the impact of treatment on morbidity and mortality. Recent data on clinical presentation and outcome are sparse in Australia. AIM:To determine the characteristics and outcome of patients presenting with a bleeding peptic ulcer to a tertiary referral cen...

journal_title：Internal medicine journal

authors： Halland M,Young M,Fitzgerald MN,Inder K,Duggan JM,Duggan A

更新日期：2011-08-01 00:00:00

abstract：:Based on the number of new cases (incidence), non-Hodgkin lymphoma is an increasingly common cancer in Australia and many developed countries. Until recently, mortality trends have been stable or slightly increasing. However, since the year 2000, mortality has decreased every year by an average of 5.1% per year (95% c...

journal_title：Internal medicine journal

authors： Coory M,Gill D

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:An adequately powered, double-blind, multisite, randomised controlled trial has shown no net clinical benefit for subcutaneous ketamine over placebo in the management of cancer pain refractory to combination opioid and co-analgesic therapy. The results of the trial were disseminated widely both nationally an...

journal_title：Internal medicine journal

authors： Hardy JR,Spruyt O,Quinn SJ,Devilee LR,Currow DC

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:There is a global concern that physician-researchers are 'a dying breed'. Recent studies of clinical career choices of Australian medical students and doctors have signalled the rising age of medical graduates, generational shifts in work-life attitudes and increased proportion of female graduates. There are...

journal_title：Internal medicine journal

authors： Mills JMZ,Januszewski AS,Robinson BG,Traill CL,Jenkins AJ,Keech AC

更新日期：2019-02-01 00:00:00

abstract：:Association between tumour necrosis alpha inhibitors and weight gain has been reported. We examined weight change in our cohort of inflammatory bowel disease patients treated with infliximab (IFX) for over 12 months, its associations and financial implications. Two-thirds of patients gained weight during the course of...

journal_title：Internal medicine journal

authors： Kaazan P,Tan Z,Bednarz J,Hughes J,Grafton R,Andrews JM

更新日期：2020-09-01 00:00:00

abstract：AIMS:To characterize long-term mortality trends for infectious and parasitic diseases in Australia during the twentieth century, explore influencing factors and provide suggestions to health policy-makers. METHODS:A descriptive study was conducted. Deaths due to communicable diseases from 1907 to 1997 were tallied, ac...

journal_title：Internal medicine journal

authors： Bi P,Whitby M,Walker S,Parton KA

更新日期：2003-04-01 00:00:00

abstract：:We describe three patients with severe refractory cutaneous polyarteritis nodosa, resulting in painful ulcers involving the lower limbs and causing toe necrosis. Due to the severity of the cutaneous manifestations, the three patients received intravenous immunoglobulins at a dose of 1 g/kg/day for 2 days monthly. Afte...

journal_title：Internal medicine journal

authors： Marie I,Miranda S,Girszyn N,Soubrane JC,Vandhuick T,Levesque H

更新日期：2012-04-01 00:00:00

abstract：:This study aimed to identify the incidence of perioperative acute upper gastrointestinal bleeding (UGIB) in our hip fracture patients; to evaluate the characteristics, management and clinical outcomes of these patients; and to explore risk factors and protective factors. Of the 1691 consecutive patients admitted for s...

journal_title：Internal medicine journal

authors： Liu J,Gupta R,Hay K,Pulle C,Rahman T,Pandy S

更新日期：2018-06-01 00:00:00

abstract：:Significant developments have occurred in the discipline of palliative care in the modern era. This paper shall explore those developments, challenge some widely held misconceptions about the role and daily practice of the discipline, highlight the growing recognition of the role of palliative care in non-malignant di...

journal_title：Internal medicine journal

authors： Brennan F

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, enters human cells by binding of its viral protein to the aminopeptidase angiotensin-converting enzyme 2 (ACE2). This has led to speculation whether treatment with renin-angiotensin system (RAS) inhibitors was asso...

journal_title：Internal medicine journal

authors： Koshy AN,Murphy AC,Farouque O,Ramchand J,Burrell LM,Yudi MB

更新日期：2020-12-01 00:00:00

abstract：:Individualised drug dosing has been shown to improve patient outcomes and reduce adverse drug events. One method of individualised medicine is the Bayesian approach, which uses prior information about how the population responds to therapy, to inform clinicians about how a specific individual is responding to their cu...

journal_title：Internal medicine journal

authors： Donagher J,Martin JH,Barras MA

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Informed consent is a mainstay of clinical practice, with both moral and legal forces. Material disclosure about extreme treatments, however, is unlikely to convey the full impact of the experience of treatment. Informed consent may be flawed under such circumstances. The aims of this study were to compare e...

journal_title：Internal medicine journal

authors： Little M,Jordens CF,McGrath C,Montgomery K,Lipworth W,Kerridge I

更新日期：2008-08-01 00:00:00

abstract：:Conventional teaching on the mechanisms and treatment of spontaneous pneumothorax is either obviously wrong or based on a misunderstanding of the natural history of the condition. Spontaneous pneumothorax is a generally benign, self-limiting condition where conservative management should be considered. If intervention...

journal_title：Internal medicine journal

authors： Simpson G

更新日期：2010-03-01 00:00:00

abstract：:We documented temporal changes in the use of lipid-lowering medications and achievement of cholesterol targets in an Australian diabetes clinic. The number of patients using lipid-lowering therapy for primary or secondary cardiovascular prevention increased from 6 to 69% between 1993-1995 and 2014-2016, which correspo...

journal_title：Internal medicine journal

authors： Kiburg KV,Ward GM,O'Neal DN,MacIsaac RJ

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Myelodysplastic syndrome (MDS), a haematological disorder of the elderly, has been formally classified as a neoplastic disease for 10 years. AIMS:Our aim was to collate national cancer registry incidence data to describe the epidemiology of MDS in New Zealand. METHODS:The New Zealand Cancer Registry has no...

journal_title：Internal medicine journal

authors： Rodger EJ,Morison IM

更新日期：2012-11-01 00:00:00

abstract：:To share our experience of establishing an acute outreach service to nursing homes and to evaluate the impact of such service on emergency department presentations, data were drawn from a pre-existing database from 2013 to 2017. Of the 986 acute patients treated in 12 nursing homes over a 23-month period, the acute ge...

journal_title：Internal medicine journal

authors： Chan DKY,Liu FX,Irwanto D,Prasetyo D,Ozorio G,Li F,Smith M,Sharma A,Chen J

更新日期：2018-11-01 00:00:00

abstract：AIM:To carry out an audit of the appropriateness of fresh-frozen plasma (FFP) and platelets (Plt) transfusion with reference to the Australian National Health and Medical Research Council/Australian Society of Blood Transfusion Clinical Practice Guidelines, and to assess the impact of a self-educating transfusion reque...

journal_title：Internal medicine journal

authors： Hui CH,Williams I,Davis K

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Hypercholesterolaemia is a pivotal risk factor for cardiovascular and cerebrovascular disease and is treated with many effective lipid-lowering agents. Statins are often used alone or in combination with ezetimibe. Combination therapy is more effective because of its complementary approach, which has major b...

journal_title：Internal medicine journal

authors： Luo L,Yuan X,Huang W,Ren F,Zhu H,Zheng Y,Tang L

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The altered status of iron metabolism is reported in hereditary haemochromatosis and in non-alcoholic liver fatty disease. We investigated the relation between the H63D HFE mutation gene and non-alcoholic steatohepatitis (NASH). METHODS:We studied as outpatients, 272 Italian persons with NASH and compared t...

journal_title：Internal medicine journal

authors： Neri S,Pulvirenti D,Signorelli S,Ignaccolo L,Tsami A,Mauceri B,Misseri M,Interlandi D,Cutuli N,Castellino P

更新日期：2008-04-01 00:00:00

abstract：:Haemophagocytic lymphohistiocytosis (HLH) is rare disorder characterised by immune activation leading to cytokine storm and end-organ failure. It is associated with poor prognosis. HLH is predominantly a disease of early childhood, where it often results from genetic defects that impair cytotoxic function of natural k...

journal_title：Internal medicine journal

authors： Lee WI,Talaulikar D,Cook MC

更新日期：2020-05-10 00:00:00

abstract：:Prior randomised studies of immunoglobulin replacement therapy have studied mixed populations with or without a history of infections. Immunoglobulin therapy is expensive and in limited supply suggesting that optimising patient selection is of value. In this retrospective study, infection history identified high-risk ...

journal_title：Internal medicine journal

authors： Paxton L,Hawkins C,Crispin P

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Off-label use of rituximab in lupus nephritis is reported to be beneficial. While the optimal dose is unknown, the regimen of four intravenous doses of 375 mg/m(2) is commonly employed, despite expense and potential side-effects. AIM:To investigate the response to single-dose rituximab, added to standard co...

journal_title：Internal medicine journal

authors： Kotagiri P,Martin A,Hughes P,Becker G,Nicholls K

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The reported risk of depression in patients with hypomagnesaemia is controversial. AIM:The objective of this meta-analysis was to assess the association between depression and hypomagnesaemia. METHODS:A literature search was performed using MEDLINE, EMBASE, Cochrane Database and clinicaltrials.gov from inc...

journal_title：Internal medicine journal

authors： Cheungpasitporn W,Thongprayoon C,Mao MA,Srivali N,Ungprasert P,Varothai N,Sanguankeo A,Kittanamongkolchai W,Erickson SB

更新日期：2015-04-01 00:00:00