Abstract:
BACKGROUND:Hypercholesterolaemia is a pivotal risk factor for cardiovascular and cerebrovascular disease and is treated with many effective lipid-lowering agents. Statins are often used alone or in combination with ezetimibe. Combination therapy is more effective because of its complementary approach, which has major benefits for patients with unmanageable lipid levels. Extensive application of combination therapy has resulted in an increased incidence of side-effects, which has raised our concern. AIM:To evaluate the evidence associated with the safety of coadministration of ezetimibe with statins. METHODS:Three electronic databases were searched (PubMed, EMBASE and Cochrane Library) from January 2002 to October 2014. Two independent reviewers critically identify randomised controlled trials (RCT), extracted the data and assessed trial quality. A total ot 20 RCT met inclusion criteria, including 14,856 patients. A fixed-effects model was used for meta-analysis to assess the safety of combination therapy. RESULTS:Coadministration of ezetimibe and statins did not result in significant increases in total adverse events (30% vs 29%, P = 0.34), serious adverse events (2% vs 1.6%, P = 0.81), treatment discontinuations (3.5% vs 2.9%, P = 0.22), gastrointestinal adverse events (5% vs 4%, P = 0.08), allergic reactions or rashes (0.9% vs 1.3%, P = 0.33), creatine kinase > 10 × upper limit of normal (ULN) (0.2% vs 0.2%, P = 0.86), alanine aminotransferase > 3 × ULN (0.5% vs 0.4%, P = 0.96) and aspartate aminotransferase > 3 × ULN (0.4% vs 0.4%, P = 0.58). CONCLUSION:The incidence of adverse events was similar between ezetimibe-statin combination therapy and statin monotherapy; thus, we recommend combination therapy for patients with hypercholesterolaemia at high risk for cardiovascular and cerebrovascular disease.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Luo L,Yuan X,Huang W,Ren F,Zhu H,Zheng Y,Tang Ldoi
10.1111/imj.12706subject
Has Abstractpub_date
2015-05-01 00:00:00pages
546-57issue
5eissn
1444-0903issn
1445-5994journal_volume
45pub_type
杂志文章,meta分析abstract::Many publications have highlighted a lack of practical competencies in recently qualified interns. Consultation between the University of Queensland and the Medical Education Unit at Redcliffe Hospital identified key areas where intervention could lead to greater work readiness, and the development of a complementary ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2010.02272.x
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Low socioeconomic status is associated with cardiovascular diseases, and an association with atrial fibrillation (AF) could guide screening. AIM:To investigate if indices of advantage/disadvantage (IAD), index of education/occupation (IEO) and index of economic resources were associated with incident AF, in...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14214
更新日期:2019-10-01 00:00:00
abstract::Stereotactic radiation therapy has emerged as an alternative to conventional radiotherapy for treatment of Cushing disease. The aim of this study was to investigate the efficacy and safety of this treatment. Records of patients with Cushing disease treated with stereotactic radiation were reviewed. Seventeen patients ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2012.02903.x
更新日期:2012-10-01 00:00:00
abstract::Young onset dementia (YOD), where symptoms of dementia have an onset before the age of 65, has become more prominent due to the population increase from the Baby Boomer generation. This clinical perspective examines key issues in the assessment, diagnosis and management of YOD. Challenges in the assessment and diagnos...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13099
更新日期:2016-07-01 00:00:00
abstract::Inappropriate polypharmacy and its associated harm pose a significant threat to older patients. The prescribing decisions of physicians greatly influence what other practitioners prescribe. Minimising medication-related harm requires physicians to adopt a systematic approach to the deliberate and judicious deprescribi...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12693
更新日期:2015-03-01 00:00:00
abstract::The incidence and prevalence of autoimmune diseases such as rheumatoid arthritis, primary Sjögren syndrome, scleroderma and systemic lupus erythematosus (SLE) varies with geography and ethnicity. For example, SLE is reported to be more common in populations such as African-Caribbeans and Indigenous Australians (IA). A...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12039
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Timor-Leste is one of the poorest countries in the world. The East Timor Hearts Fund is a charitable organisation involving Australian cardiologists providing outreach screening and access to cardiac interventions. AIMS:To assess ten years of clinical volume, demographics and patient outcomes. Our intention...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14411
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Chronic lymphocytic leukaemia (CLL) frequently responds to chemoimmunotherapy combining cytotoxic chemotherapy and monoclonal antibodies. However, CLL is associated with significant genetic heterogeneity, and some high-risk forms are known to be chemo-resistant and associated with early relapse. AIMS:To rev...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.13680
更新日期:2017-12-01 00:00:00
abstract::A 22-year-old woman presented with methanol toxicity manifesting as headache, reduced conscious state and visual change after consuming home-made grappa. She progressed to a coma with fixed mydriasis and severe acidaemia (pH 6.55). She was treated with empirical antidote administration (intravenous ethanol) and enhanc...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13725
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Surveillance for colorectal neoplasia in inflammatory bowel disease (IBD) is widely practised despite a lack of convincing mortality reduction. The psychological impact of this approach is largely unexplored. AIM:To examine psychological well-being among IBD subjects undergoing colonoscopic surveillance for...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12317
更新日期:2014-02-01 00:00:00
abstract::This review summarises the available clinical trials data investigating the effects of glucose lowering on mortality in patients admitted to hospital with acute myocardial infarction. The results of these studies are inconclusive with no clear evidence that this intervention has additional benefit over and above routi...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2008.01638.x
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Tobacco cessation after acute myocardial infarction (AMI) substantially improves outcome but how effective individual programmes are needs to be established. To date, few studies have examined this factor. AIMS:To assess the outcome of two smoking cessation programmes after AMI. METHODS:One hundred and nin...
journal_title:Internal medicine journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1445-5994.2001.00110.x
更新日期:2001-11-01 00:00:00
abstract::Parathyroid hormone (PTH) is the predominant regulator of calcium/phosphate homeostasis in the human body. Beside this classical function, preclinical and clinical studies indicated a relevant role for PTH in mobilisation of bone marrow-derived cells into peripheral blood. In addition, recombinant PTH (teriparatide) w...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12830
更新日期:2015-08-01 00:00:00
abstract::Based on the number of new cases (incidence), non-Hodgkin lymphoma is an increasingly common cancer in Australia and many developed countries. Until recently, mortality trends have been stable or slightly increasing. However, since the year 2000, mortality has decreased every year by an average of 5.1% per year (95% c...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2008.01809.x
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The effects of empagliflozin on cardiac structure and function are not known. AIMS:To examine the changes in cardiac structure and function following the addition of empagliflozin in patients with type 2 (T2D) diabetes using cardiac magnetic resonance (CMR) imaging. METHODS:Twenty patients attending a spec...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14260
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Numerous studies have shown differences in pain perception between men and women, which may affect pain management strategies. AIM:Our primary aim was to investigate whether there are gender-based differences in pain management in patients admitted to our emergency department with acute, non-specific abdomi...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2010.02255.x
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:In 2004, the Pharmaceutical Benefits Scheme (PBS) listed infliximab as a subsidised treatment for ankylosing spondylitis (AS). Eligibility to receive this treatment for AS involved fulfilling several criteria. AIM:To examine the medical literature concerning response to tumor necrosis factor (TNF)-alpha inh...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2006.01004.x
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Clopidogrel is an antiplatelet drug increasingly used in the secondary prevention of atherosclerotic vascular events. Compared with aspirin, clopidogrel has marginal additional efficacy and similar safety, but carries a substantial price premium. It remains unclear whether its use is cost-effective. AIMS:(i...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2004.00697.x
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Cigarette smoking prevalence has been declining over decades in Western countries especially in higher socioeconomic groups. Employees of Australian hospitals span the socioeconomic spectrum, but there are few data on smoking prevalence from these workplaces. Because smoking is a health hazard, some argue th...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2010.02221.x
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Advanced training in gastroenterology currently consists of 2 years of core training and 1 elective (non-core) year. We surveyed gastroenterologists 2-7 years following completion of training to determine the strengths and weaknesses of their training. METHODS:All gastroenterologists were invited to partici...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2012.02757.x
更新日期:2013-04-01 00:00:00
abstract::Paradigms for managing acromegaly have undergone major changes in the past two decades. This has been brought about by combining surgical, pharmacological and radiotherapeutic approaches that provide tight biochemical control to reduce mortality to that of the general population. The biochemical targets for treatment ...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2006.01097.x
更新日期:2006-07-01 00:00:00
abstract:AIMS:Low molecular weight heparins (LMWH) permit safe and effective treatment of uncomplicated deep venous thrombosis (DVT) at home. The aim of this study was to evaluate the cost minimization, cost shifting and patient satisfaction associated with at-home DVT treatment using the LMWH enoxaparin, compared to standard i...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND: According to the International Prognostic Scoring System (IPSS), sole +8 is categorized as intermediate cytogenetic subgroup. But as some myelodysplastic syndrome (MDS) patients with +8 perhaps progress quickly to acute leukaemia and have shorter survival, some reports have suggested that +8 should be cate...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.02061.x
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Magnetic resonance imaging (MRI) accuracy after neoadjuvant systemic therapy (NST) for breast cancer varies according to hormone receptor (HR), human epidermal growth factor receptor type-2 (HER2) subtype and Ki-67 proliferation index. Whether MRI accuracy varies by genomic signatures is unknown. We examined...
journal_title:Internal medicine journal
pub_type: 杂志文章,多中心研究
doi:10.1111/imj.13617
更新日期:2018-06-01 00:00:00
abstract::Clarithromycin is the most documented cytochrome P450 3A4 (CYP3A4) inhibitor to cause an adverse interaction with simvastatin. This particular case is of interest as rhabdomyolysis only occurred after an increase in the dose of clarithromycin. The patient developed raised cardiac biomarkers without any obvious cardiac...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12464
更新日期:2014-07-01 00:00:00
abstract::Legionella species are a common cause of community-acquired pneumonia, infrequently complicated by cavitary disease. We describe Legionella pneumophila pneumonia and abscess formation in an immunosuppressed patient receiving corticosteroid therapy for metastatic breast carcinoma. The predisposing role of corticosteroi...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2011.02508.x
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Congestive heart failure (CHF) is a frequent complication of most diseases of the heart. CHF is associated with impairment in several aspects of the quality of life of patients, including mood and cognitive performance. Early reports indicated that patients with CHF display deficits in memory and other intel...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1046/j.1445-5994.2001.00067.x
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:The risks are unknown for developing chronic gastrointestinal illness when personnel are relocated short term to other countries and when taking antibiotic prophylaxis in areas where malaria is endemic. AIM:To examine the associations of deployment to developed or developing countries and exposure to doxycy...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12179
更新日期:2013-08-01 00:00:00
abstract::Severe sepsis is defined as organ dysfunction in the setting of systemic inflammatory response due to infection. With changes in population age, comorbidity and the delivery of medical care, severe sepsis is increasingly common, and can present in every area of the hospital. The major obstacles to improved outcomes in...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2010.02383.x
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The reported risk of depression in patients with hypomagnesaemia is controversial. AIM:The objective of this meta-analysis was to assess the association between depression and hypomagnesaemia. METHODS:A literature search was performed using MEDLINE, EMBASE, Cochrane Database and clinicaltrials.gov from inc...
journal_title:Internal medicine journal
pub_type: 杂志文章,meta分析,评审
doi:10.1111/imj.12682
更新日期:2015-04-01 00:00:00