Pharmaceutical Benefits Scheme criteria for the use of tumour necrosis factor-alpha inhibitors in the treatment of ankylosing spondylitis in Australia: are they evidence based?

abstract：:Abstract Hyperammonaemic encephalopathy has been infrequently reported after both standard and high-dose chemotherapy for solid and haematological malignancies. It is important to consider this diagnosis for patients with unexplained behaviour changes or encephalopathy and this case report emphasizes this condition an...

journal_title：Internal medicine journal

authors： Nott L,Price TJ,Pittman K,Patterson K,Young R,Fletcher J

更新日期：2008-10-01 00:00:00

abstract：:Transfusion-related acute lung injury (TRALI) is a leading cause of transfusion related morbidity and mortality. Current concepts regarding the pathogenesis of this disorder imply a "two-hit" model in which neutrophils are sequestered in the pulmonary capillary bed, and subsequently activated by substances in the tran...

journal_title：Internal medicine journal

authors： Finlayson J,Grey D,Kavanagh L,Witt C

更新日期：2011-08-01 00:00:00

abstract：:The incidence and prevalence of autoimmune diseases such as rheumatoid arthritis, primary Sjögren syndrome, scleroderma and systemic lupus erythematosus (SLE) varies with geography and ethnicity. For example, SLE is reported to be more common in populations such as African-Caribbeans and Indigenous Australians (IA). A...

journal_title：Internal medicine journal

authors： Vincent FB,Bourke P,Morand EF,Mackay F,Bossingham D

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The effects of empagliflozin on cardiac structure and function are not known. AIMS:To examine the changes in cardiac structure and function following the addition of empagliflozin in patients with type 2 (T2D) diabetes using cardiac magnetic resonance (CMR) imaging. METHODS:Twenty patients attending a spec...

journal_title：Internal medicine journal

authors： Cohen ND,Gutman SJ,Briganti EM,Taylor AJ

更新日期：2019-08-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a prevalent, chronic and heterogeneous endocrine condition, with reproductive, metabolic and psychological features. Insulin resistance and hyperandrogenaemia are the key pathophysiological hormonal abnormalities. Insulin resistance is a significant contributor to the reproductive a...

journal_title：Internal medicine journal

authors： Shorakae S,Boyle J,Teede H

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Both low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) have been shown to be equivalent in efficacy and safety profiles for the management of pulmonary embolism (PE). AIMS:To assess the real world management of anticoagulation in PE in a tertiary hospital setting. METHODS:An audit of pat...

journal_title：Internal medicine journal

authors： Khor YH,Smith R,McDonald CF

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Ageism among health professionals is increasingly recognized, but few studies investigated hospital doctors' attitudes towards older people. The aims of this study were to investigate hospital doctors' attitudes towards older people and to determine whether factors, which were identified in studies on other ...

journal_title：Internal medicine journal

authors： Leung S,Logiudice D,Schwarz J,Brand C

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Smartphones have become novel healthcare tools for patients with diabetes. However, it is uncertain whether the smartphone application support system helps in glycaemic control in patients with type 2 diabetes. AIMS:To evaluate the efficacy and plausibility of smartphone-based integrated online real-time di...

journal_title：Internal medicine journal

authors： Ku EJ,Park JI,Jeon HJ,Oh T,Choi HJ

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND AIM:Familial Mediterranean fever (FMF) is an autosomal recessive disease characterised by recurrent episodes of painful inflammation in the abdomen, chest or joints. The association between FMF and non-amyloid glomerulopathies are unusual. In this study, we describe our experiences and observations about...

journal_title：Internal medicine journal

authors： Bashardoust B,Maleki N

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Medical Emergency Teams (MET) have been developed to identify, review and manage acutely unwell ward patients. Previous studies have suggested that there may be obstacles to the utilization and activation of the MET. AIMS:To determine the effect of a detailed education programme on the rate of utilization o...

journal_title：Internal medicine journal

authors： Jones D,Bates S,Warrillow S,Goldsmith D,Kattula A,Way M,Gutteridge G,Buckmaster J,Bellomo R

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukaemia (CLL) frequently responds to chemoimmunotherapy combining cytotoxic chemotherapy and monoclonal antibodies. However, CLL is associated with significant genetic heterogeneity, and some high-risk forms are known to be chemo-resistant and associated with early relapse. AIMS:To rev...

journal_title：Internal medicine journal

authors： Kuss BJ,Tam CS

更新日期：2017-12-01 00:00:00

abstract：AIM:Bigge Park Centre (BPC) is a sexual health clinic located in a socially disadvantaged area in Southwest Sydney. This served as a retrospective clinical audit, documenting patient demographics, identifying factors associated with virological, immunological and discordant responses, evaluating the centre's ability in...

journal_title：Internal medicine journal

authors： Hsu DC,Quin JW

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The thiopurines azathioprine and 6-mercaptopurine are recommended for maintenance of remission in inflammatory bowel disease (IBD). Measurement of concentrations of the metabolites 6-thioguanine nucleotide and 6-methylmercaptopurine helps delineate interindividual variation in metabolism that may underlie va...

journal_title：Internal medicine journal

authors： Kennedy NA,Asser TL,Mountifield RE,Doogue MP,Andrews JM,Bampton PA

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:High inflammatory bowel disease (IBD) rates have been reported in Australasia, but no state-wide studies have yet been performed. AIM:This study estimates the 1-year incidence and point prevalence of IBD in the state of Tasmania, Australia. It also reports clinical outcomes after 12 months of diagnosis in a...

journal_title：Internal medicine journal

authors： Bhatia R,Yeoh SW,Vaz K,Studd C,Wilson J,Bell S,Otahal P,Venn A

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Informed consent is a mainstay of clinical practice, with both moral and legal forces. Material disclosure about extreme treatments, however, is unlikely to convey the full impact of the experience of treatment. Informed consent may be flawed under such circumstances. The aims of this study were to compare e...

journal_title：Internal medicine journal

authors： Little M,Jordens CF,McGrath C,Montgomery K,Lipworth W,Kerridge I

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Hypercholesterolaemia is a pivotal risk factor for cardiovascular and cerebrovascular disease and is treated with many effective lipid-lowering agents. Statins are often used alone or in combination with ezetimibe. Combination therapy is more effective because of its complementary approach, which has major b...

journal_title：Internal medicine journal

authors： Luo L,Yuan X,Huang W,Ren F,Zhu H,Zheng Y,Tang L

更新日期：2015-05-01 00:00:00

abstract：:Young onset dementia (YOD), where symptoms of dementia have an onset before the age of 65, has become more prominent due to the population increase from the Baby Boomer generation. This clinical perspective examines key issues in the assessment, diagnosis and management of YOD. Challenges in the assessment and diagnos...

journal_title：Internal medicine journal

authors： Draper B,Withall A

更新日期：2016-07-01 00:00:00

abstract：:Diabetes can lead to a myriad of microvascular and macrovascular complications - with the leading cause of mortality in diabetes being cardiovascular disease. Low-density lipoprotein cholesterol, along with non-high-density lipoprotein cholesterol and triglycerides are proven, modifiable risk factors for cardiovascula...

journal_title：Internal medicine journal

authors： Cheung YM,O'Brien R,Ekinci EI

更新日期：2019-12-01 00:00:00

abstract：:There is accumulating evidence that point-of-care delivery of clinical information such as evidence-based medicine, practice guidelines and drug information can streamline clinical practice and reduce preventable errors. In Australia, hospital-based physicians have -generally been slow to fully use these resources to ...

journal_title：Internal medicine journal

authors： Wilcox RA,Whitham EM

更新日期：2003-11-01 00:00:00

abstract：:Inappropriate polypharmacy and its associated harm pose a significant threat to older patients. The prescribing decisions of physicians greatly influence what other practitioners prescribe. Minimising medication-related harm requires physicians to adopt a systematic approach to the deliberate and judicious deprescribi...

journal_title：Internal medicine journal

authors： Scott IA,Le Couteur DG

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Many patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have type 2 respiratory failure (T2RF). Often arterial blood gases are not performed and correlation with venous blood gases (VBG) is controversial. The venous pH and bicarbonate (HCO3 ) are useful, but VBG pCO2 (PvCO2 )...

journal_title：Internal medicine journal

authors： Wong EKC,Lee PCS,Ansary S,Asha S,Wong KKH,Yee BJ,Ng AT

更新日期：2019-07-01 00:00:00

abstract：:A cross-sectional survey of 265 adult patients with haematological malignancy, haemoglobinopathy or human immunodeficiency virus was performed to determine the potential risk of infection from animal exposures. One hundred and thirty-seven (52%) owned an animal; the majority were dogs (74%) and cats (39%), but 14% own...

journal_title：Internal medicine journal

authors： Gurry GA,Campion V,Premawardena C,Woolley I,Shortt J,Bowden DK,Kaplan Z,Dendle C

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Cancer treatment near end of life is not likely to add meaningful benefit and minimising intervention rates has been promoted as an indicator of quality of care. Population-based analysis of treatment allows comparative analysis of treatment rates and provides insight into patterns of care. AIMS:To report a...

journal_title：Internal medicine journal

authors： Pitson G,Matheson L,Garrard B,Eastman P,Rogers M

更新日期：2020-05-01 00:00:00

abstract：:Severe sepsis is defined as organ dysfunction in the setting of systemic inflammatory response due to infection. With changes in population age, comorbidity and the delivery of medical care, severe sepsis is increasingly common, and can present in every area of the hospital. The major obstacles to improved outcomes in...

journal_title：Internal medicine journal

authors： Huggan PJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The ACT Genetic Service at The Canberra Hospital evaluates the genetic risk of individuals for inherited diseases, and provides counselling and genetic testing where appropriate. AIM:To evaluate the current referral practice for patients with a personal and/or family history of breast and/or ovarian cancer,...

journal_title：Internal medicine journal

authors： Aitken L,Warwick L,Davis A

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Current diagnostic tools are inadequate for reliable prediction of prostate cancer (PCa) aggressiveness in patients with localised disease. This results in many patients being exposed to potentially unnecessary invasive treatment and its associated morbidities. In order to develop appropriate treatment strat...

journal_title：Internal medicine journal

authors： Algotar AM,Thompson PA,Ranger-Moore J,Stratton MS,Hsu CH,Ahmann FR,Nagle RB,Stratton SP

更新日期：2012-04-01 00:00:00

abstract：:Depression is the leading cause of non-fatal disease burden in Australia. Recently, increasing public recognition, together with the development of more integrated medical and psychological healthcare services has resulted in significant improvements. New pathophysiological models incorporate structural brain changes ...

journal_title：Internal medicine journal

authors： Hickie IB,Naismith SL,Norrie LM,Scott EM

更新日期：2009-11-01 00:00:00

abstract：:Transient ischaemic attack (TIA) if untreated carries a high risk of early stroke and is associated with poorer long-term survival. There have been recent advances in the understanding of TIA, its investigations, management and organisation of services for patient care. Clinically, patients are diagnosed TIA if they h...

journal_title：Internal medicine journal

authors： Phan TG,Sanders L,Srikanth V

更新日期：2013-04-01 00:00:00

abstract：:Clarithromycin is the most documented cytochrome P450 3A4 (CYP3A4) inhibitor to cause an adverse interaction with simvastatin. This particular case is of interest as rhabdomyolysis only occurred after an increase in the dose of clarithromycin. The patient developed raised cardiac biomarkers without any obvious cardiac...

journal_title：Internal medicine journal

authors： Page SR,Yee KC

更新日期：2014-07-01 00:00:00

abstract：:Thrombotic microangiopathy (TMA) is a potentially fatal complication in solid organ and bone marrow transplant patients, with reported incidence of 0.5-3% and mortality of about 75%. To emphasise the importance of early diagnosis and prompt commencement of therapy results in improved clinical outcomes. A retrospective...

journal_title：Internal medicine journal

authors： Nwaba A,MacQuillan G,Adams LA,Garas G,Delriviere L,Augustson B,DeBoer B,Moody H,Jeffrey GP

更新日期：2013-03-01 00:00:00