Effects of empagliflozin treatment on cardiac function and structure in patients with type 2 diabetes: a cardiac magnetic resonance study.

Abstract:

BACKGROUND:The effects of empagliflozin on cardiac structure and function are not known. AIMS:To examine the changes in cardiac structure and function following the addition of empagliflozin in patients with type 2 (T2D) diabetes using cardiac magnetic resonance (CMR) imaging. METHODS:Twenty patients attending a specialist diabetes service recommended for treatment with empagliflozin, and 8 control patients with T2D on stable glucose lowering therapy were recruited for cardiac imaging. Participants underwent CMR scans at baseline and 6 months. Inclusion criteria were established T2D, age < 75 years, estimated glomerular filtration rate ≥45 mL/min/1.73 m2 . RESULTS:17 of 20 in the empagliflozin group, and all of 8 in the control group completed the study. Empagliflozin therapy was associated with reduction in left ventricular end diastolic volume 155 mL (137 mL, 174 mL) at baseline to 145 mL (125 mL, 165 mL) at 6 months, P < 0.01, compared with the control group 153 mL (128 mL, 179 mL) at baseline and 158 mL (128 mL, 190 mL), not significant. There were no differences in measures of left ventricular mass, ejection fraction, heart rate or markers of cardiac fibrosis at baseline and 6 months in either group. CONCLUSIONS:This is the first CMR study to examine the effects of empagliflozin on cardiac function and structure, showing evidence of reduced end diastolic volume. This is likely to reflect change in plasma volume, and may explain the reduced cardiovascular death and heart failure seen in the EMPA-REG OUTCOME trial.

journal_name

Intern Med J

authors

Cohen ND,Gutman SJ,Briganti EM,Taylor AJ

doi

10.1111/imj.14260

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

1006-1010

issue

8

eissn

1444-0903

issn

1445-5994

journal_volume

49

pub_type

杂志文章
  • Evaluation of the off-label usage of rituximab in a large teaching hospital in New South Wales.

    abstract::A retrospective review of patients receiving rituximab off label in a large teaching hospital was conducted between July 2002 and January 2006. The indication, dosing regimen, efficacy and cost of rituximab were evaluated. Rituximab was prescribed for three clinical indications; acute organ transplant rejection, post-...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2007.01406.x

    authors: Sharma R,Koller L,Barclay P,Liddle C

    更新日期:2007-08-01 00:00:00

  • Evidence-based prescribing of drugs for secondary prevention of acute coronary syndrome in Aboriginal and non-Aboriginal patients admitted to Western Australian hospitals.

    abstract:AIMS:To assess the level of evidence-based drug prescribing for acute coronary syndrome (ACS) at discharge from Western Australian (WA) hospitals and determine predictors of such prescribing in Aboriginal and non-Aboriginal patients. METHODS:All Aboriginal (2002-2004) and a random sample of non-Aboriginal (2003) hospi...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/imj.12375

    authors: Gausia K,Katzenellenbogen JM,Sanfilippo FM,Knuiman MW,Thompson PL,Hobbs MS,Thompson SC

    更新日期:2014-04-01 00:00:00

  • The undivided patient: a retrospective cohort analysis of specialty referrals made from inpatient general medical units comparing regional to metropolitan practice.

    abstract:BACKGROUND:In an era of growing subspecialisation there has been significant research into the role, determinants and outcomes of outpatient referrals but very little on inpatient specialty referrals from general medical units. AIMS:This study aims to describe and compare the rate of specialty referrals from inpatient...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.12480

    authors: Brown MG,Campbell D,Maydom BW

    更新日期:2014-09-01 00:00:00

  • Suboptimal management of unfractionated heparin compared with low-molecular-weight heparin in the management of pulmonary embolism.

    abstract:BACKGROUND:Both low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) have been shown to be equivalent in efficacy and safety profiles for the management of pulmonary embolism (PE). AIMS:To assess the real world management of anticoagulation in PE in a tertiary hospital setting. METHODS:An audit of pat...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.12376

    authors: Khor YH,Smith R,McDonald CF

    更新日期:2014-04-01 00:00:00

  • Attractions and barriers to Australian physician-researcher careers.

    abstract:BACKGROUND:There is a global concern that physician-researchers are 'a dying breed'. Recent studies of clinical career choices of Australian medical students and doctors have signalled the rising age of medical graduates, generational shifts in work-life attitudes and increased proportion of female graduates. There are...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14086

    authors: Mills JMZ,Januszewski AS,Robinson BG,Traill CL,Jenkins AJ,Keech AC

    更新日期:2019-02-01 00:00:00

  • Understanding and reducing work-related psychological distress in interns: a systematic review.

    abstract::The aim of this study was to collate and evaluate studies investigating either the factors influencing work-related psychological distress in postgraduate year one (PGY1) doctors or the strategies designed to reduce it. This is a systematic review conducted in May 2014. The data sources were key databases (MEDLINE, Ps...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/imj.12785

    authors: Facey AD,Tallentire V,Selzer RM,Rotstein L

    更新日期:2015-10-01 00:00:00

  • Circuit breakers for addiction.

    abstract::The phenomenon of addiction is complex, although its expression clinically is relatively straightforward. There is a series of neurophysiological changes that mediate changes in the mesolimbic and mesocortical systems which in turn lead to disturbances in reward mechanisms. These then act to perpetuate the cycle of in...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2007.01350.x

    authors: Foy A

    更新日期:2007-05-01 00:00:00

  • Underappreciation of non-alcoholic fatty liver disease by primary care clinicians: limited awareness of surrogate markers of fibrosis.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a common cause of incidental liver test abnormalities. General practitioners (GP) have a key role in identifying people with NAFLD at risk of significant liver disease. Recent specialist guidelines emphasise the use of fibrosis algorithms or serum biomarkers rathe...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13667

    authors: Patel PJ,Banh X,Horsfall LU,Hayward KL,Hossain F,Johnson T,Stuart KA,Brown NN,Saad N,Clouston A,Irvine KM,Russell AW,Valery PC,Williams S,Powell EE

    更新日期:2018-02-01 00:00:00

  • Stereotactic radiosurgery for treatment of Cushing disease: an Australian experience.

    abstract::Stereotactic radiation therapy has emerged as an alternative to conventional radiotherapy for treatment of Cushing disease. The aim of this study was to investigate the efficacy and safety of this treatment. Records of patients with Cushing disease treated with stereotactic radiation were reviewed. Seventeen patients ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2012.02903.x

    authors: Wein L,Dally M,Bach LA

    更新日期:2012-10-01 00:00:00

  • Ironic case of hepatic dysfunction following the global withdrawal of sitaxentan.

    abstract::A patient with pulmonary arterial hypertension secondary to systemic sclerosis was successfully treated with sitaxentan prior to its worldwide withdrawal (because of hepatotoxicity concerns), but then ironically experienced acute hepatic dysfunction during substitute bosentan therapy, and was eventually stabilised on ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.12007

    authors: Don GW,Joseph F,Celermajer DS,Corte TJ

    更新日期:2012-12-01 00:00:00

  • Resurrecting New Zealand's public healthcare system or a charity hospital in every town?

    abstract::Radical market-oriented health reforms in New Zealand in the early 1990s failed to deliver key financial targets, resulted in unnecessary patient deaths, adversely affected public healthcare services, induced serious tensions between clinicians and managers and encouraged a predisposition to private healthcare. A more...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14903

    authors: Nicholls MG,Frampton CM,Bagshaw PF

    更新日期:2020-07-01 00:00:00

  • Outcomes of concurrent Caesarean delivery and pheochromocytoma resection in late pregnancy.

    abstract::Undiagnosed pheochromocytoma in pregnancy is associated with significant maternal and foetal mortality. Herein we reviewed five cases of pheochromocytoma in pregnancy occurring during late pregnancy. The mean age at presentation was 30.6 years, and the gestational age ranged from 26 to 36 weeks. All patients had eleva...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.12118

    authors: Song Y,Liu J,Li H,Zeng Z,Bian X,Wang S

    更新日期:2013-05-01 00:00:00

  • Trends in stroke reperfusion treatment and outcomes in New Zealand.

    abstract:BACKGROUND:Intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT) can help reverse stroke symptoms in selected patients but are both time sensitive interventions. AIMS:To report current stroke reperfusion rates and quality measures as well as trends over time in New Zealand. METHOD:Since 2015 New Zealand ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14682

    authors: Hedlund F,Leighs A,Barber PA,Lundström E,Wu TY,Ranta A

    更新日期:2020-11-01 00:00:00

  • Demonstrable professionalism: linking patient-centred care and revalidation.

    abstract::The move by the Medical Board of Australia to commence a conversation with the medical profession about revalidation reflects that patient-centred care is at the heart of good medical practice. Patients judge their doctors' commitment to them based on whether their individual interactions with doctors meet their needs...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/imj.12280

    authors: Phelps G,Dalton S

    更新日期:2013-11-01 00:00:00

  • High Frequency of Anticoagulation Management Errors Preceding Ischemic Strokes in Atrial Fibrillation.

    abstract:BACKGROUND AND AIMS:Anticoagulants are recommended to prevent cardioembolic stroke in most patients with atrial fibrillation (AF). Management errors with anticoagulation and use of aspirin instead of anticoagulants have been documented worldwide, especially with vitamin K antagonists. We assessed the rate of anticoagul...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.15167

    authors: Wong E,Aaqib M,Thijs V

    更新日期:2020-12-21 00:00:00

  • Unrelated umbilical cord blood transplantation for adults with haematological malignancies: results from a single Australian centre.

    abstract:BACKGROUND:A number of haematological malignancies can be cured by allogeneic stem cell transplantation but only approximately 30% of Australians have a suitable histocompatible related donor. Matched donors can be found on international registries of unrelated volunteers for a proportion of the remaining patients. For...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2006.01079.x

    authors: Bradstock KF,Hertzberg MS,Kerridge IH,Svennilson J,McGurgan M,Huang G,Antonenas V,Gottlieb DJ

    更新日期:2006-06-01 00:00:00

  • International travel in the immunocompromised patient: a cross-sectional survey of travel advice in 254 consecutive patients.

    abstract:AIMS:Our primary aim was to determine the rate of overseas travel in immunocompromised individuals attending appropriate clinics at an Australian tertiary care hospital. We also aimed to characterise health-seeking behaviour prior to travel and investigated sources of pre-travel advice, compared travel patterns and act...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.12753

    authors: Bialy C,Horne K,Dendle C,Kanellis J,Littlejohn G,Ratnam I,Woolley I

    更新日期:2015-06-01 00:00:00

  • Role of long-term mechanical circulatory support in patients with advanced heart failure.

    abstract::Advanced heart failure represents a small proportion of patients with heart failure that possess high-risk features associated with high hospital readmission rates, significant functional impairment and mortality. Identification of those who have progressed to, or are near a state of advanced heart failure should prom...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/imj.12817

    authors: Stokes MB,Bergin P,McGiffin D

    更新日期:2016-05-01 00:00:00

  • Phase II study of prolonged ambulatory infusion carboplatin and oral etoposide for patients progressing through hormonal therapy for prostate cancer.

    abstract:AIM:To develop a well-tolerated outpatient chemotherapy regimen for hormone-insensitive prostate cancer. METHOD:Forty patients received carboplatin 20 mg/m2 by continuous ambulatory infusion with oral etoposide 50 mg/day for 21 days repeated every 6 weeks. RESULTS:Four patients had a partial response and 16 patients ...

    journal_title:Internal medicine journal

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1445-5994.2005.00864.x

    authors: Olver I,Keefe D,Myers M

    更新日期:2005-07-01 00:00:00

  • Hypomagnesaemia linked to depression: a systematic review and meta-analysis.

    abstract:BACKGROUND:The reported risk of depression in patients with hypomagnesaemia is controversial. AIM:The objective of this meta-analysis was to assess the association between depression and hypomagnesaemia. METHODS:A literature search was performed using MEDLINE, EMBASE, Cochrane Database and clinicaltrials.gov from inc...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/imj.12682

    authors: Cheungpasitporn W,Thongprayoon C,Mao MA,Srivali N,Ungprasert P,Varothai N,Sanguankeo A,Kittanamongkolchai W,Erickson SB

    更新日期:2015-04-01 00:00:00

  • Delays in presentation and diagnosis of pulmonary tuberculosis: a retrospective study of a tertiary health service in Western Melbourne, 2011-2014.

    abstract:BACKGROUND:Effective tuberculosis (TB) control relies on early diagnosis and prompt treatment commencement. AIM:To investigate delays in presentation and diagnosis of pulmonary TB (PTB) in a low incidence setting in Western Melbourne. METHODS:A single-centred retrospective observational cohort study of symptomatic pa...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13551

    authors: Williams E,Cheng AC,Lane GP,Guy SD

    更新日期:2018-02-01 00:00:00

  • "Iatrogenic Medication Errors reported to the Victorian Poisons Information Centre".

    abstract:BACKGROUND:Iatrogenic medication errors are a cause of medical morbidity and mortality. They result in significant cost to the Australian healthcare system each year. There is limited Australian evidence describing the iatrogenic errors occurring within the hospital system. AIMS:To examine and describe iatrogenic medi...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14940

    authors: Bourke EM,Greene S,Macleod D,Robinson J

    更新日期:2020-06-15 00:00:00

  • Synovial osteochondromatosis.

    abstract::A 75-year-old man of Fijian-Indian extraction complained of a 3-year history of progressive right knee pain and stiffness which were limiting his mobility. On examination, multiple hard nodules were palpable in the popliteal fossa and along the path of the quadriceps tendon. The joint line was not tender, knee flexion...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1046/j.1445-5994.2002.00260.x

    authors: Langguth DM,Klestov A,Denaro C

    更新日期:2002-08-01 00:00:00

  • Suboptimal management of cardiovascular risk factors in coronary heart disease patients in primary care occurs particularly in women.

    abstract:BACKGROUND:Patients with established coronary heart disease (CHD) are at the highest risk of further events. Despite proven therapies, secondary prevention is often suboptimal. General practitioners (GPs) are in an ideal position to improve secondary prevention. AIM:To contrast management of cardiovascular risk factor...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2011.02534.x

    authors: Driscoll A,Beauchamp A,Lyubomirsky G,Demos L,McNeil J,Tonkin A

    更新日期:2011-10-01 00:00:00

  • Acute administration of conjugated equine oestrogen does not improve exercise-induced myocardial ischaemia in men with coronary artery disease.

    abstract:BACKGROUND:The parenteral administration of oestradiol acutely protects against exercise-induced myocardial ischaemia in women, but whether this effect is sex-specific is not known. AIMS:The effects of acutely administered conjugated equine oestrogen on exercise-induced myocardial ischaemia in men with established cor...

    journal_title:Internal medicine journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1445-5994.2003.00346.x

    authors: Davis SR,Bradbury J,Bell R,Johns JA

    更新日期:2003-05-01 00:00:00

  • Mortality rate of alcoholic liver disease and risk of hospitalization for alcoholic liver cirrhosis, alcoholic hepatitis and alcoholic liver failure in Australia between 1993 and 2005.

    abstract:BACKGROUND:  Alcoholic liver disease (ALD) is an important contributor to the total burden of alcohol-related harm; however, the morbidity of different types of ALD in Australia has not been described. The aim of this study was to investigate recent trends in hospital admission rates among alcoholic liver cirrhosis, al...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2010.02279.x

    authors: Liang W,Chikritzhs T,Pascal R,Binns CW

    更新日期:2011-01-01 00:00:00

  • Association of doxycycline use with the development of gastroenteritis, irritable bowel syndrome and inflammatory bowel disease in Australians deployed abroad.

    abstract:BACKGROUND:The risks are unknown for developing chronic gastrointestinal illness when personnel are relocated short term to other countries and when taking antibiotic prophylaxis in areas where malaria is endemic. AIM:To examine the associations of deployment to developed or developing countries and exposure to doxycy...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.12179

    authors: Lee TW,Russell L,Deng M,Gibson PR

    更新日期:2013-08-01 00:00:00

  • Conditions associated with extreme hyperferritinaemia (>3000 μg/L) in adults.

    abstract:BACKGROUND:The clinical significance of extreme hyperferritinaemia has come under scrutiny with the increasing recognition of haemophagocytic lymphohistiocytosis (HLH) in adults. Most studies of hyperferritinaemia have focused on serum ferritin greater than 1000 μg/L, often in ambulatory patients. The conditions associ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.12768

    authors: Wormsbecker AJ,Sweet DD,Mann SL,Wang SY,Pudek MR,Chen LY

    更新日期:2015-08-01 00:00:00

  • Impact of the Royal Australasian College of Physicians' clinical examination preparation on basic physician trainee assessment of jugular venous pressure.

    abstract::Australian internal medicine trainees undergo intensive training in preparation for the Royal Australasian College of Physicians (RACP) clinical examination. Trainees preparing for the 2013 RACP clinical examination assessed the jugular venous pressure (JVP) of patients, with central venous pressure monitoring in the ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13178

    authors: Sibbin CP,Bihari S,Russell P

    更新日期:2016-09-01 00:00:00

  • The clinical spectrum of omega-5-gliadin allergy.

    abstract:BACKGROUND:IgE-mediated allergy to the wheat protein omega-5-gliadin (O5G) is associated with wheat-dependent exercise-induced anaphylaxis (WDEIA), where exercise acts as a cofactor, triggering anaphylaxis after wheat ingestion. The wider application of O5G-specific IgE (sIgE) testing has revealed that the manifestatio...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13091

    authors: Le TA,Al Kindi M,Tan JA,Smith A,Heddle RJ,Kette FE,Hissaria P,Smith WB

    更新日期:2016-06-01 00:00:00