Stereotactic radiosurgery for treatment of Cushing disease: an Australian experience.

abstract：BACKGROUND:High baseline level of soluble suppression of tumourigenicity 2 (sST2) was an independent predictor of cardiovascular death and heart failure in ST-segment elevation myocardial infarction (STEMI). AIMS:To investigate the value of serum sST2 baseline levels in predicting myocardial reperfusion in patients wi...

journal_title：Internal medicine journal

authors： Bai S,Liu H,Wu H,Wang X,Li R,Li X,Li X,Zhang L,Chen T,Du R

更新日期：2020-08-01 00:00:00

abstract：:A patient with pulmonary arterial hypertension secondary to systemic sclerosis was successfully treated with sitaxentan prior to its worldwide withdrawal (because of hepatotoxicity concerns), but then ironically experienced acute hepatic dysfunction during substitute bosentan therapy, and was eventually stabilised on ...

journal_title：Internal medicine journal

authors： Don GW,Joseph F,Celermajer DS,Corte TJ

更新日期：2012-12-01 00:00:00

abstract：:Despite the inclusion of investigator-industry pecuniary and non-pecuniary associations in published clinical trials, the benefit of such disclosures may be limited. Two recent pivotal phase III drug studies that raised conflict of interest issues are discussed. It is recommended that in the future, a firewall should ...

journal_title：Internal medicine journal

authors： Carney SL

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) is a subgroup of oncogene addicted lung cancer that predicts response to tyrosine kinase inhibitors (TKI). However, there is variability in response and survival outcomes in patients with EGFR mutation treated with TKI. AIM:T...

journal_title：Internal medicine journal

authors： Ding PN,Roberts TL,Chua W,Becker TM,Descallar J,Yip PY,Bray V

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Smartphones have become novel healthcare tools for patients with diabetes. However, it is uncertain whether the smartphone application support system helps in glycaemic control in patients with type 2 diabetes. AIMS:To evaluate the efficacy and plausibility of smartphone-based integrated online real-time di...

journal_title：Internal medicine journal

authors： Ku EJ,Park JI,Jeon HJ,Oh T,Choi HJ

更新日期：2020-12-01 00:00:00

abstract：:Risk factors for venous thromboembolism in cancer vary between tumours. Leucocytosis, thrombocytosis, tumour histology and vascular compression may drive thrombosis in ovarian cancer. Thrombosis developed in 13.4% of our patients. Higher median leucocyte, neutrophil and monocyte counts were related to thrombosis. Thro...

journal_title：Internal medicine journal

authors： López-Salazar J,Ramírez-Tirado LA,Gómez-Contreras N,Pacheco-Bravo I,Cortés E,Gallardo D,Arrieta O,Cesarman-Maus G

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:  Several cellular pathways are implicated in the pathogenesis of pulmonary arterial hypertension (PAH) and attempts to arrest disease progression with a single drug would not be expected to succeed in the medium term. In clinical practice, combination therapy is often used in patients deteriorating on monot...

journal_title：Internal medicine journal

authors： Keogh A,Strange G,Kotlyar E,Williams T,Kilpatrick D,Macdonald P,Brown K,Pidoux A,Kermeen F,Steele P,Dalton B,Gabbay E

更新日期：2011-03-01 00:00:00

abstract：:(Neo)adjuvant chemotherapy for early stage breast cancer is associated with side-effects, resulting in increased emergency department (ED) presentations. Treatment-related toxicity can affect quality of life, compromise chemotherapy delivery and treatment outcomes, and increase healthcare use. We performed a retrospec...

journal_title：Internal medicine journal

authors： Tang M,Horsley P,Lewis CR

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Acute coronary syndromes (ACS) management is now well informed by guidelines extrapolated from clinical trials. However, most of these data have been acquired outside the local context. We sought to describe the current patterns of ACS care in Australia. METHODS:The Acute Coronary Syndrome Prospective Audit...

journal_title：Internal medicine journal

authors： Chew DP,Amerena J,Coverdale S,Rankin J,Astley C,Brieger D

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:There is no mechanism in place for monitoring or quality improvement of cancer multidisciplinary meetings (MDM) in Australia. AIM:To develop a peer-review process for quality improvement of MDM. METHODS:This project involved three phases: (i) development of a draft peer-review framework, supporting documen...

journal_title：Internal medicine journal

authors： Johnson CE,Slavova-Azmanova N,Saunders C

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Low dose computed tomography (LDCT) screening can reduce lung cancer deaths in high risk individuals yet current Australian guidelines do not recommend screening. Little is known about current screening practices in Australia. METHODS:A survey was distributed to a nationally-representative sample of 4000 Au...

journal_title：Internal medicine journal

authors： Abeyweera PD,Brims FJH,Piccolo F,Lei C,Manners D

更新日期：2020-04-01 00:00:00

abstract：:The insulin tolerance test is considered the gold standard for assessing the hypothalamic-pituitary-adrenal and growth hormone (GH) axes, but its use varies considerably among different endocrine units. We recommend using the insulin tolerance test to assess the hypothalamic-pituitary-adrenal axis within 3 months of p...

journal_title：Internal medicine journal

authors： Sarlos S,Inder WJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The effects of empagliflozin on cardiac structure and function are not known. AIMS:To examine the changes in cardiac structure and function following the addition of empagliflozin in patients with type 2 (T2D) diabetes using cardiac magnetic resonance (CMR) imaging. METHODS:Twenty patients attending a spec...

journal_title：Internal medicine journal

authors： Cohen ND,Gutman SJ,Briganti EM,Taylor AJ

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Both low-molecular-weight heparin (LMWH) and unfractionated heparin (UFH) have been shown to be equivalent in efficacy and safety profiles for the management of pulmonary embolism (PE). AIMS:To assess the real world management of anticoagulation in PE in a tertiary hospital setting. METHODS:An audit of pat...

journal_title：Internal medicine journal

authors： Khor YH,Smith R,McDonald CF

更新日期：2014-04-01 00:00:00

abstract：:Interaction between doctors and the pharmaceutical industry is long-standing and ingrained in modern practice. Doctors-in-training are at a vulnerable stage of their careers, both in requiring knowledge and forming lasting relationships. There is evidence that limiting contact between industry and junior doctors has a...

journal_title：Internal medicine journal

authors： Pokorny AM,Gittins CB

更新日期：2015-10-01 00:00:00

abstract：:Previously, management of hypertension has concentrated on lowering elevated blood pressure. However, the target has shifted to reducing absolute cardiovascular (CV) risk. It is estimated that two in three Australian adults have three or more CV risk factors at the same time. Moderate reductions in several risk factor...

journal_title：Internal medicine journal

authors： Sindone A,Erlich J,Lee C,Newman H,Suranyi M,Roger SD

更新日期：2016-03-01 00:00:00

abstract：:Perhexiline is a prophylactic anti-anginal agent that ameliorates the metabolic basis for myocardial ischaemia and is increasingly used in the management of acute coronary syndromes. No intravenous preparation is available and usual oral loading regimens require 2-3 days to achieve therapeutic drug levels. Two patient...

journal_title：Internal medicine journal

authors： Philpott A,Chandy S,Morris R,Horowitz JD

更新日期：2004-06-01 00:00:00

abstract：:The move by the Medical Board of Australia to commence a conversation with the medical profession about revalidation reflects that patient-centred care is at the heart of good medical practice. Patients judge their doctors' commitment to them based on whether their individual interactions with doctors meet their needs...

journal_title：Internal medicine journal

authors： Phelps G,Dalton S

更新日期：2013-11-01 00:00:00

abstract：:Diabetes mellitus (DM) has been found to be associated with cardiovascular disease. The goal of this study is to evaluate the prevalence of asthma in patients with type II DM after adjusting for other comorbid conditions. We used patient treatment files of inpatients' admissions containing discharge diagnosis (Classif...

journal_title：Internal medicine journal

authors： Hashemzadeh M,Movahed MR

更新日期：2009-10-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) haplogroups are 'neutral polymorphisms' in the mtDNA genome, which have accumulated and persisted along maternal lineages as the human population has migrated worldwide. Three ethnically distinct lineages of human mtDNA populations have been identified: European, characterized by nine haplogr...

journal_title：Internal medicine journal

authors： Manwaring N,Jones MM,Wang JJ,Rochtchina E,Mitchell P,Sue CM

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Many studies support the role of bilirubin as a cytoprotector in chronic inflammatory diseases, such as stroke and atherosclerosis. AIM:To investigate the relationship between serum total bilirubin levels and functional dependence in older adults. METHODS:Data from the National Health and Nutrition Examina...

journal_title：Internal medicine journal

authors： Kao TW,Chou CH,Wang CC,Chou CC,Hu J,Chen WL

更新日期：2012-11-01 00:00:00

abstract：:A 75-year-old man of Fijian-Indian extraction complained of a 3-year history of progressive right knee pain and stiffness which were limiting his mobility. On examination, multiple hard nodules were palpable in the popliteal fossa and along the path of the quadriceps tendon. The joint line was not tender, knee flexion...

journal_title：Internal medicine journal

authors： Langguth DM,Klestov A,Denaro C

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND/AIM:Although induction chemotherapy comprising high-dose cytarabine (HiDAC) in combination with idarubicin and etoposide or 'ICE' for adult acute myeloid leukaemia (AML) produces a complete remission rate of nearly 80%, gastrointestinal toxicity is significant. Omission of etoposide may produce similar clini...

journal_title：Internal medicine journal

authors： Low M,Lee D,Coutsouvelis J,Patil S,Opat S,Walker P,Schwarer A,Salem H,Avery S,Spencer A,Wei A

更新日期：2013-03-01 00:00:00

abstract：:An acute pulmonary embolism (aPE) is characterised by occlusion of one or more pulmonary arteries. Physiological disturbance may be minimal, but often cardiac output decreases as the right ventricle attempts to overcome increased afterload. Additionally, ventilation-perfusion mismatches can develop in affected vascula...

journal_title：Internal medicine journal

authors： Hepburn-Brown M,Darvall J,Hammerschlag G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:High inflammatory bowel disease (IBD) rates have been reported in Australasia, but no state-wide studies have yet been performed. AIM:This study estimates the 1-year incidence and point prevalence of IBD in the state of Tasmania, Australia. It also reports clinical outcomes after 12 months of diagnosis in a...

journal_title：Internal medicine journal

authors： Bhatia R,Yeoh SW,Vaz K,Studd C,Wilson J,Bell S,Otahal P,Venn A

更新日期：2019-05-01 00:00:00

abstract：:Here we report the case of a 69-year-old Chinese Han woman who presented with liver cirrhosis, diabetes mellitus, skin hyperpigmentation, hyperferritinaemia and high transferrin saturation. Subsequent genetic analyses identified a novel heterozygous mutation (p.Cys326Phe) in the SLC40A1 gene. This is the first report ...

journal_title：Internal medicine journal

authors： Chen SR,Yang LQ,Chong YT,Jie YS,Wu YK,Yang J,Lin GL,Li XH

更新日期：2015-06-01 00:00:00

abstract：:In this essay, I reflect on my experience as a multiple sclerosis patient in order to identify some of the unique challenges that chronic disability poses in the physician-patient relationship. I suggest that it is important to broaden the goals of the clinical encounter to incorporate personal (as opposed to simply b...

journal_title：Internal medicine journal

authors： Toombs SK

更新日期：2004-11-01 00:00:00

abstract：:Ambulatory care is an important service for patients with the COVID-19 infection especially in a regional area where most of the patients underwent home isolation. Escalation of treatment and timely transition to inpatient care are critical when COVID-19 patients deteriorate. Equally important is ensuring transfer int...

journal_title：Internal medicine journal

authors： Lwin N,Burgess J,Johnston C,Johnson N,Chung S

更新日期：2020-10-01 00:00:00

abstract：:Growth hormone (GH) replacement therapy was recently recommended by the Pharmaceutical Benefits Advisory Committee (PBAC) for listing on the Pharmaceutical Benefits Scheme for adults with severe GH deficiency and impaired quality of life. This approval was significant for two reasons. First, the application was initia...

journal_title：Internal medicine journal

authors： Lipworth W,Ambler G,Burt MG,Fairchild J,Inder WJ,Werther G,Ho K

更新日期：2018-08-01 00:00:00

abstract：:The author, a physician in late middle age reflects on his own medical career, the aging of those who have taught him and also of those whom he has taught. He describes the sense of ennui and déjà vu. The things that seemed important as a younger doctor seem less important. He has adopted a different paradigm and has ...

journal_title：Internal medicine journal

authors： Allen RK

更新日期：2006-12-01 00:00:00