Abstract:
:Despite the inclusion of investigator-industry pecuniary and non-pecuniary associations in published clinical trials, the benefit of such disclosures may be limited. Two recent pivotal phase III drug studies that raised conflict of interest issues are discussed. It is recommended that in the future, a firewall should be erected between industry and investigators.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Carney SLdoi
10.1111/j.1445-5994.2012.02940.xsubject
Has Abstractpub_date
2012-11-01 00:00:00pages
1255-6issue
11eissn
1444-0903issn
1445-5994journal_volume
42pub_type
杂志文章abstract::The differential diagnosis of Parkinsonian syndromes is challenging, especially in the elderly as they often have complex presentations. Nuclear imaging modalities can increase diagnostic accuracy. Single-photon emission tomography (SPECT) using the ligand (99m Tc)-TRODAT-1 is used overseas but is yet to be approved i...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14017
更新日期:2018-09-01 00:00:00
abstract::The annual Leonard Ball Orations illustrate changing perspectives in Australia over 30 years on medical and social effects of misuse of alcohol and other substances. The first oration, in 1968, examined causal factors in the context of 'agent', 'purveyor' and 'host' and provided themes for subsequent orators. In regar...
journal_title:Internal medicine journal
pub_type: 历史文章,杂志文章
doi:10.1046/j.1445-5994.2001.00068.x
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Early involvement of palliative care and advance care planning improves quality of life outcomes and survival for patients with advanced lung cancer, however there are barriers to implementation. AIMS AND METHODS:A single-centre prospective audit reviewing "Goals of Care" (GOC) form completion and palliativ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14817
更新日期:2020-03-23 00:00:00
abstract:BACKGROUND:Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) is a subgroup of oncogene addicted lung cancer that predicts response to tyrosine kinase inhibitors (TKI). However, there is variability in response and survival outcomes in patients with EGFR mutation treated with TKI. AIM:T...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13555
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The NSW Clinical Excellence commission introduced the "Between the Flags" program in response to the death of a young patient as a system wide approach for early detection and management of the deteriorating patient in all 242 NSW hospitals. The impact of BTF implementation on the 35 larger hospitals with IC...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14812
更新日期:2020-03-04 00:00:00
abstract::We review the aetiology of scleroderma from an epidemiological perspective examining genetic, environmental and stochastic risk factors. The presence of familial clustering (but with low twin concordance) suggests a genetic contribution, and this has been confirmed with recent candidate gene and genome-wide associatio...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2011.02706.x
更新日期:2012-03-01 00:00:00
abstract:AIMS:To characterize long-term mortality trends for infectious and parasitic diseases in Australia during the twentieth century, explore influencing factors and provide suggestions to health policy-makers. METHODS:A descriptive study was conducted. Deaths due to communicable diseases from 1907 to 1997 were tallied, ac...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2003.00354.x
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Long-term prognosis of acute coronary syndromes (ACS) in human immunodeficiency virus (HIV)-infected patients is unknown. AIMS:To compare outcomes after ACS in HIV-infected and uninfected patients. METHODS:Retrospective observational study. HIV cases were matched with two HIV-uninfected controls for age, s...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14744
更新日期:2020-12-01 00:00:00
abstract::Significant developments have occurred in the discipline of palliative care in the modern era. This paper shall explore those developments, challenge some widely held misconceptions about the role and daily practice of the discipline, highlight the growing recognition of the role of palliative care in non-malignant di...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13520
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:We presumed that identification of the factors associated with improvement of fatty livers disease (FLD) would support the therapeutic options for FLD. The goal of this study was to clarify what clinical characteristics are associated with biochemical and sonographic improvements in the non-alcoholic populat...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2005.00887.x
更新日期:2005-08-01 00:00:00
abstract::Transient ischaemic attack (TIA) if untreated carries a high risk of early stroke and is associated with poorer long-term survival. There have been recent advances in the understanding of TIA, its investigations, management and organisation of services for patient care. Clinically, patients are diagnosed TIA if they h...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12059
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Acute coronary syndromes (ACS) management is now well informed by guidelines extrapolated from clinical trials. However, most of these data have been acquired outside the local context. We sought to describe the current patterns of ACS care in Australia. METHODS:The Acute Coronary Syndrome Prospective Audit...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01435.x
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:The consumption of Energy Drinks (Edks), has increased significantly in the last years, with a growing market that is estimated to reach $61 billion by 2021 worldwide. Several studies demonstrated the physiological and pathological effects of these substances contained in Edks. The most common ingredient con...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.14881
更新日期:2020-05-05 00:00:00
abstract:BACKGROUND:The short Synacthen test is widely used to assess the hypothalamus pituitary adrenal axis in the outpatient setting. In the inpatient setting however, technical difficulties to adhere to the protocol may pose a challenge for using this test. AIMS:In this study we attempted to find the most suitable basal se...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15033
更新日期:2020-08-24 00:00:00
abstract:BACKGROUND:Polyserositis (PS) is the inflammation, with effusion, of different serous membranes. It has been associated with different aetiologies, but the aetiology of PS remains unknown in a high percentage of patients. AIMS:The general objective of this retrospective study was to analyse the aetiology of PS cases s...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13966
更新日期:2018-08-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is a prevalent, chronic and heterogeneous endocrine condition, with reproductive, metabolic and psychological features. Insulin resistance and hyperandrogenaemia are the key pathophysiological hormonal abnormalities. Insulin resistance is a significant contributor to the reproductive a...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12495
更新日期:2014-08-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) has been described as a cause of thrombotic microangiopathy, especially thrombotic thrombocytopenic purpura (TTP). Haemolytic-uraemic syndrome (HUS) is less frequent in SLE. We report a case of such an association during an episode of severe lupus nephritis in a young woman, who was ...
journal_title:Internal medicine journal
pub_type: 信件
doi:10.1111/j.1445-5994.2011.02591.x
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Delirium is common in hospitalised patients but its epidemiology remains poorly characterised. AIMS:To test the hypothesis that patient demographics, clinical phenotype, management and outcomes of patient with delirium in hospital ward patients differ from intensive care unit (ICU) patients. METHODS:Retros...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14287
更新日期:2019-12-01 00:00:00
abstract::This paper uses a case example to review the current legal status of advance directives, as well as their ethical rationale. We draw attention to ongoing efforts to institutionalize advance directives, and to some of the tractable and intractable reasons why advance directives are ineffective. We then introduce the co...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2005.00915.x
更新日期:2005-09-01 00:00:00
abstract::ABSTRACT Treatment of invasive fungal infections is increasingly complex. Amphotericin B deoxycholate has long been the mainstay of treatment. However, there has been increasing recognition of both the propensity for nephro-toxicity in haematology, transplant and intensive care patients as well as its adverse impact o...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1444-0903.2004.00541.x
更新日期:2004-04-01 00:00:00
abstract::An 11-year-old boy presented with hepatic failure secondary to parvovirus B19 infection, requiring urgent liver transplantation. His recovery was complicated by primary Epstein-Barr virus and cytomegalovirus infections. He subsequently developed aplastic anaemia that has been refractory to antithymocyte globulin and c...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2006.01293.x
更新日期:2007-03-01 00:00:00
abstract::We documented temporal changes in the use of lipid-lowering medications and achievement of cholesterol targets in an Australian diabetes clinic. The number of patients using lipid-lowering therapy for primary or secondary cardiovascular prevention increased from 6 to 69% between 1993-1995 and 2014-2016, which correspo...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13691
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Teaching, mentoring and supervision (TMS) are fundamental skills with a specific commitment within the Royal Australasian College of Physicians (RACP) professional practice framework. The new basic training standards include 'use of appropriate educational techniques to facilitate the learning of peers, juni...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14935
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:The cost of diabetes is high for both the individual and society. Future health-care planning requires patient-level diabetes-attributable health-care cost data that have not previously been available for Australia. AIM:To determine Australian national direct diabetes-attributable health-care costs for know...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2006.01014.x
更新日期:2006-03-01 00:00:00
abstract::The negative health effects of the 2003 invasion of Iraq should act as a watershed in the medical profession's approach to violent conflict. ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01319.x
更新日期:2007-04-01 00:00:00
abstract::The author, a physician in late middle age reflects on his own medical career, the aging of those who have taught him and also of those whom he has taught. He describes the sense of ennui and déjà vu. The things that seemed important as a younger doctor seem less important. He has adopted a different paradigm and has ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2006.01256.x
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:There is no mechanism in place for monitoring or quality improvement of cancer multidisciplinary meetings (MDM) in Australia. AIM:To develop a peer-review process for quality improvement of MDM. METHODS:This project involved three phases: (i) development of a draft peer-review framework, supporting documen...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.13374
更新日期:2017-05-01 00:00:00
abstract:AIMS:To evaluate the effectiveness of a new locality-based integrated diabetes care service for people with Type 2 diabetes in an inner regional area. METHODS:A quasi-experimental evaluation comparing baseline and follow up clinical data collected from general practices and specialist services participating in an inte...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15211
更新日期:2021-01-20 00:00:00
abstract::Growth hormone (GH) replacement therapy was recently recommended by the Pharmaceutical Benefits Advisory Committee (PBAC) for listing on the Pharmaceutical Benefits Scheme for adults with severe GH deficiency and impaired quality of life. This approval was significant for two reasons. First, the application was initia...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.13943
更新日期:2018-08-01 00:00:00
abstract::A retrospective review of patients receiving rituximab off label in a large teaching hospital was conducted between July 2002 and January 2006. The indication, dosing regimen, efficacy and cost of rituximab were evaluated. Rituximab was prescribed for three clinical indications; acute organ transplant rejection, post-...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01406.x
更新日期:2007-08-01 00:00:00