Abstract:
:The differential diagnosis of Parkinsonian syndromes is challenging, especially in the elderly as they often have complex presentations. Nuclear imaging modalities can increase diagnostic accuracy. Single-photon emission tomography (SPECT) using the ligand (99m Tc)-TRODAT-1 is used overseas but is yet to be approved in Australia. Three pilot cases of clinically unclear Parkinsonian syndromes from the Royal North Shore Hospital Aged Care Department who underwent (99m Tc)-TRODAT-1 scans are described. From experience overseas, the (99m Tc)-TRODAT-1 scan has clinical utility in the differential diagnosis of Parkinsonian syndromes. (99m Tc)-TRODAT-1 has a lower cost and greater availability than other ligands. Our initial scan findings are largely consistent with the clinical picture, but low specific binding can affect scan interpretation. (99m Tc)-TRODAT-1 is a potential tool in the differential diagnosis of Parkinsonian syndromes. Further experience regarding its effect on patient outcomes and cost effectiveness is required before routine clinical use can be recommended.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Wong D,Veitch P,Schembri Gdoi
10.1111/imj.14017subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1132-1137issue
9eissn
1444-0903issn
1445-5994journal_volume
48pub_type
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