Apixaban versus enoxaparin in the prevention of venous thromboembolism following total knee arthroplasty: a single-centre, single-surgeon, retrospective analysis.

Abstract:

BACKGROUND:There is a high risk of developing venous thromboembolism (VTE) following total knee arthroplasty (TKA). Conventional thromboprophylactic agents have limitations, such as route of administration, the need for monitoring, narrow therapeutic windows and interactions. Apixaban is a new oral anticoagulant with the potential to overcome these limitations. AIMS:To report the efficacy and safety of apixaban and low-molecular-weight heparin, enoxaparin, in VTE prophylaxis following TKA. METHODS:This single-centre, single-surgeon, retrospective analysis included 506 consecutive patients who underwent TKA between 2009 and 2015 and received enoxaparin or apixaban as thromboprophylaxis. Baseline characteristics of patients, in-hospital rates of VTE, total DVT, proximal or distal DVT, pulmonary embolism, bleeding outcomes and mortality were compared between the two groups. RESULTS:In-hospital VTE occurred in 22 (8.9%) patients in the enoxaparin group and 11 (4.5%) patients in the apixaban group (P = 0.049). Nine (3.6%) patients in the enoxaparin group and one (0.4%) in the apixaban group experienced a postoperative drop in haemoglobin ≥20 g/L that either necessitated transfusion of ≥2 units blood, caused haemodynamic instability or both (P = 0.020). Thirty-five patients experienced other bleeding events, with 25 (9.9%) in the enoxaparin group and 10 (4.0%) in the apixaban group (P = 0.009). There were no statistically significant differences in rates of total DVT, proximal or distal DVT, pulmonary embolism or mortality between the groups. CONCLUSIONS:Compared with enoxaparin, thromboprophylaxis with apixaban resulted in a lower VTE incidence and fewer haemorrhagic complications.

journal_name

Intern Med J

authors

King DA,Pow RE,Dickison DM,Vale PR

doi

10.1111/imj.13139

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

1030-7

issue

9

eissn

1444-0903

issn

1445-5994

journal_volume

46

pub_type

杂志文章
  • High Frequency of Anticoagulation Management Errors Preceding Ischemic Strokes in Atrial Fibrillation.

    abstract:BACKGROUND AND AIMS:Anticoagulants are recommended to prevent cardioembolic stroke in most patients with atrial fibrillation (AF). Management errors with anticoagulation and use of aspirin instead of anticoagulants have been documented worldwide, especially with vitamin K antagonists. We assessed the rate of anticoagul...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.15167

    authors: Wong E,Aaqib M,Thijs V

    更新日期:2020-12-21 00:00:00

  • Young onset dementia.

    abstract::Young onset dementia (YOD), where symptoms of dementia have an onset before the age of 65, has become more prominent due to the population increase from the Baby Boomer generation. This clinical perspective examines key issues in the assessment, diagnosis and management of YOD. Challenges in the assessment and diagnos...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13099

    authors: Draper B,Withall A

    更新日期:2016-07-01 00:00:00

  • Prescribing in the oldest old inpatients: a retrospective analysis of patients referred for specialist geriatric consultation.

    abstract:BACKGROUND:While medications may prolong life and prevent morbidity in older people, adverse effects of polypharmacy are increasingly recognised. As patients age and become frail, prescribing may be expected to focus more on symptom control and minimise potentially harmful preventive medication use that confer little b...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13526

    authors: Ilango S,Pillans P,Peel NM,Scott I,Gray LC,Hubbard RE

    更新日期:2017-09-01 00:00:00

  • No effect of sleeved arms on the accuracy of blood pressure measurement.

    abstract:BACKGROUND:It is recommended that blood pressure should be measured on a bare upper arm with an appropriately sized cuff. However, in practice, it is more convenient to measure blood pressure on sleeved arms. AIMS:We aim to examine the effect of sleeved arms on the accuracy of blood pressure measurement. METHODS:Pati...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.15071

    authors: Li Y,Li Y,Li F,Liu D,Zhang Y,Cui X,Cui W

    更新日期:2020-09-25 00:00:00

  • A will and a way to fund medicines for rare diseases: the story of human growth hormone replacement for adults with growth hormone deficiency.

    abstract::Growth hormone (GH) replacement therapy was recently recommended by the Pharmaceutical Benefits Advisory Committee (PBAC) for listing on the Pharmaceutical Benefits Scheme for adults with severe GH deficiency and impaired quality of life. This approval was significant for two reasons. First, the application was initia...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/imj.13943

    authors: Lipworth W,Ambler G,Burt MG,Fairchild J,Inder WJ,Werther G,Ho K

    更新日期:2018-08-01 00:00:00

  • 'Is she experiencing any pain?': disability and the physician-patient relationship.

    abstract::In this essay, I reflect on my experience as a multiple sclerosis patient in order to identify some of the unique challenges that chronic disability poses in the physician-patient relationship. I suggest that it is important to broaden the goals of the clinical encounter to incorporate personal (as opposed to simply b...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2004.00700.x

    authors: Toombs SK

    更新日期:2004-11-01 00:00:00

  • "Iatrogenic Medication Errors reported to the Victorian Poisons Information Centre".

    abstract:BACKGROUND:Iatrogenic medication errors are a cause of medical morbidity and mortality. They result in significant cost to the Australian healthcare system each year. There is limited Australian evidence describing the iatrogenic errors occurring within the hospital system. AIMS:To examine and describe iatrogenic medi...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14940

    authors: Bourke EM,Greene S,Macleod D,Robinson J

    更新日期:2020-06-15 00:00:00

  • Intravenous immunoglobulins as treatment of severe cutaneous polyarteritis nodosa.

    abstract::We describe three patients with severe refractory cutaneous polyarteritis nodosa, resulting in painful ulcers involving the lower limbs and causing toe necrosis. Due to the severity of the cutaneous manifestations, the three patients received intravenous immunoglobulins at a dose of 1 g/kg/day for 2 days monthly. Afte...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2012.02739.x

    authors: Marie I,Miranda S,Girszyn N,Soubrane JC,Vandhuick T,Levesque H

    更新日期:2012-04-01 00:00:00

  • Mortality rate of alcoholic liver disease and risk of hospitalization for alcoholic liver cirrhosis, alcoholic hepatitis and alcoholic liver failure in Australia between 1993 and 2005.

    abstract:BACKGROUND:  Alcoholic liver disease (ALD) is an important contributor to the total burden of alcohol-related harm; however, the morbidity of different types of ALD in Australia has not been described. The aim of this study was to investigate recent trends in hospital admission rates among alcoholic liver cirrhosis, al...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2010.02279.x

    authors: Liang W,Chikritzhs T,Pascal R,Binns CW

    更新日期:2011-01-01 00:00:00

  • De novo activating epidermal growth factor mutations (EGFR) in small-cell lung cancer.

    abstract::In Australia, mutations in epidermal growth factor mutations (EGFR) occur in 15% of patients diagnosed with non-small-cell lung cancer and are found with higher frequency in female, non-smokers of Asian ethnicity. Activating mutations in the EGFR gene are rarely described in SCLC. We present two cases of de novo EGFR ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.13531

    authors: Thai A,Chia PL,Russell PA,Do H,Dobrovic A,Mitchell P,John T

    更新日期:2017-09-01 00:00:00

  • Hyperammonaemic encephalopathy associated with rituximab-containing chemotherapy.

    abstract::Abstract Hyperammonaemic encephalopathy has been infrequently reported after both standard and high-dose chemotherapy for solid and haematological malignancies. It is important to consider this diagnosis for patients with unexplained behaviour changes or encephalopathy and this case report emphasizes this condition an...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2008.01772.x

    authors: Nott L,Price TJ,Pittman K,Patterson K,Young R,Fletcher J

    更新日期:2008-10-01 00:00:00

  • Bronchial thermoplasty in severe asthma in Australia.

    abstract:BACKGROUND:Bronchial thermoplasty (BT) is an approved bronchoscopic intervention for the treatment of severe asthma. However, limited published experience exists outside of clinical trials regarding patient selection and outcomes achieved. AIMS:To evaluate the effectiveness and safety of BT in patients with severe ast...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,多中心研究

    doi:10.1111/imj.13372

    authors: Langton D,Sha J,Ing A,Fielding D,Wood E

    更新日期:2017-05-01 00:00:00

  • Atypical haemolytic uraemic syndrome treated with the complement inhibitor eculizumab: the experience of the Australian compassionate access cohort.

    abstract:BACKGROUND/AIM:This study aimed to report the clinical characteristics and outcomes of Australian patients treated with eculizumab for atypical haemolytic uraemic syndrome (aHUS). METHODS:A retrospective cohort study was undertaken of all patients in Australia treated with eculizumab provided in a compassionate access...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.12864

    authors: Mallett A,Hughes P,Szer J,Tuckfield A,Van Eps C,Cambell SB,Hawley C,Burke J,Kausman J,Hewitt I,Parnham A,Ford S,Isbel N

    更新日期:2015-10-01 00:00:00

  • Pandemics in ancient Greek and Roman coinage: medical memories at the service of hope.

    abstract::Medical goddesses and gods invoked in the Hippocratic Oath were called on in times of pandemics along with Greek physicians such as Galen of Pergamum. Ancient Greek and Roman coinage provide insights into the coexisting religious and rational approaches to medicine rooted in Classical Antiquity, portraying medical sym...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.15111

    authors: Iniesta I

    更新日期:2020-12-01 00:00:00

  • Practical guidelines for the acute emergency sedation of the severely agitated older patient.

    abstract::The vulnerability of older people to serious underlying medical illness and adverse effects of psychotropics means that the safe and effective treatment of severe agitation can be lifesaving, the primary management goals being to create a safe environment for the patient and others, and to facilitate assessment and tr...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1445-5994.2011.02560.x

    authors: Peisah C,Chan DK,McKay R,Kurrle SE,Reutens SG

    更新日期:2011-09-01 00:00:00

  • Complicated skin and soft tissue infections in remote indigenous communities.

    abstract::The burden and consequences of skin infections for remote living indigenous people are high. While skin infections are recognised as an antecedent to conditions such as acute rheumatic fever in children, data are limited concerning skin infection complications such as cellulitis, abscesses and osteomyelitis in older c...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14858

    authors: Thomas L,Bowen AC,Tong SYC

    更新日期:2020-06-01 00:00:00

  • Media reporting of health interventions in New Zealand: a retrospective analysis.

    abstract:AIM:To evaluate New Zealand media articles on their coverage of key issues regarding health interventions and whether it is consistent with available evidence. METHODS:A retrospective analysis was carried out of all articles published in five New Zealand media sources over a 6-week period between 15 October and 26 Nov...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/imj.13936

    authors: Robinson C,Cutfield N,Mottershead J,Sharples K,Richards R,Kingan J,Ledgard C,Liyanage A,McLean J,Nahab F,Stewart F,Strachan S,Tucker K,Zhang Z

    更新日期:2018-08-01 00:00:00

  • Central nervous system is a sanctuary site for chronic myelogenous leukaemia treated with imatinib mesylate.

    abstract::Imatinib mesylate (IM) is currently used as the first therapeutic choice against chronic myelogenous leukaemia (CML). Because IM poorly penetrates the blood-brain barrier, IM-treated CML patients may have a potential risk of central nervous system (CNS) involvement. Here we report a case with lymphoid blast crisis iso...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1445-5994.2009.01947.x

    authors: Isobe Y,Sugimoto K,Masuda A,Hamano Y,Oshimi K

    更新日期:2009-06-01 00:00:00

  • Spontaneous pneumothorax: time for some fresh air.

    abstract::Conventional teaching on the mechanisms and treatment of spontaneous pneumothorax is either obviously wrong or based on a misunderstanding of the natural history of the condition. Spontaneous pneumothorax is a generally benign, self-limiting condition where conservative management should be considered. If intervention...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1445-5994.2009.02155.x

    authors: Simpson G

    更新日期:2010-03-01 00:00:00

  • Infliximab-related weight gain in inflammatory bowel disease: associations and financial impacts.

    abstract::Association between tumour necrosis alpha inhibitors and weight gain has been reported. We examined weight change in our cohort of inflammatory bowel disease patients treated with infliximab (IFX) for over 12 months, its associations and financial implications. Two-thirds of patients gained weight during the course of...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14987

    authors: Kaazan P,Tan Z,Bednarz J,Hughes J,Grafton R,Andrews JM

    更新日期:2020-09-01 00:00:00

  • Conflict of interest: will it ever end?

    abstract::Despite the inclusion of investigator-industry pecuniary and non-pecuniary associations in published clinical trials, the benefit of such disclosures may be limited. Two recent pivotal phase III drug studies that raised conflict of interest issues are discussed. It is recommended that in the future, a firewall should ...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2012.02940.x

    authors: Carney SL

    更新日期:2012-11-01 00:00:00

  • Implementing practice change in chronic cancer pain management: clinician response to a phase III study of ketamine.

    abstract:BACKGROUND:An adequately powered, double-blind, multisite, randomised controlled trial has shown no net clinical benefit for subcutaneous ketamine over placebo in the management of cancer pain refractory to combination opioid and co-analgesic therapy. The results of the trial were disseminated widely both nationally an...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.12442

    authors: Hardy JR,Spruyt O,Quinn SJ,Devilee LR,Currow DC

    更新日期:2014-06-01 00:00:00

  • Outcomes of concurrent Caesarean delivery and pheochromocytoma resection in late pregnancy.

    abstract::Undiagnosed pheochromocytoma in pregnancy is associated with significant maternal and foetal mortality. Herein we reviewed five cases of pheochromocytoma in pregnancy occurring during late pregnancy. The mean age at presentation was 30.6 years, and the gestational age ranged from 26 to 36 weeks. All patients had eleva...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.12118

    authors: Song Y,Liu J,Li H,Zeng Z,Bian X,Wang S

    更新日期:2013-05-01 00:00:00

  • Seasonal recurrence of food bolus obstruction in eosinophilic esophagitis.

    abstract:BACKGROUND:Eosinophilic esophagitis (EoE) is a newly recognised condition that is apparently increasing in prevalence, and the aetiology is poorly understood. The role of aeroallergens in EoE is controversial, given the success of dietary therapy. Massive aeroallergen exposure leading to food bolus obstruction events (...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,多中心研究

    doi:10.1111/imj.12790

    authors: Philpott HL,Nandurkar S,Thien F,Bloom S,Lin E,Goldberg R,Boyapati R,Finch A,Royce SG,Gibson PR

    更新日期:2015-09-01 00:00:00

  • Patients with multiple myeloma over a large catchment of 2.5 million square kilometres: a Western Australia retrospective survival review.

    abstract::Multiple myeloma is an incurable malignancy of plasma cells. We retrospectively reviewed the survival outcomes of patients with multiple myeloma in Western Australia (WA) public hospitals over a 10-year period. We did not detect a difference in survival between patients residing the metropolitan Perth and regional are...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14905

    authors: Ng TF,Burrow S,Leahy M,Augustson B,Trentino K,De Kraa R,Wright M,Carnley B

    更新日期:2020-07-01 00:00:00

  • Mortality and airflow obstruction in asthma: a 17-year follow-up study.

    abstract:BACKGROUND:Asthma is associated with fixed airflow obstruction and an increased risk of death. The aim of this study was to relate asthma mortality and airflow obstruction to severity of asthma in a cohort of patients with chronic asthma studied over a 17-year period. METHODS:In 1980, asthma severity based on symptoms...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/j.1445-5994.2006.01214.x

    authors: Panizza JA,James AL,Ryan G,de Klerk N,Finucane KE

    更新日期:2006-12-01 00:00:00

  • What is new in lipid-lowering therapies in diabetes?

    abstract::Diabetes can lead to a myriad of microvascular and macrovascular complications - with the leading cause of mortality in diabetes being cardiovascular disease. Low-density lipoprotein cholesterol, along with non-high-density lipoprotein cholesterol and triglycerides are proven, modifiable risk factors for cardiovascula...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/imj.14291

    authors: Cheung YM,O'Brien R,Ekinci EI

    更新日期:2019-12-01 00:00:00

  • Bronchiectasis.

    abstract::Bronchiectasis is generally classified into cystic fibrosis and non-cystic fibrosis bronchiectasis. This review article describes non-cystic fibrosis bronchiectasis in adults. Bronchiectasis can be considered a heterogeneous condition characterized by irreversible airway dilatation with chronic bronchial infection/inf...

    journal_title:Internal medicine journal

    pub_type: 杂志文章,评审

    doi:10.1111/j.1445-5994.2006.01219.x

    authors: King P,Holdsworth S,Freezer N,Holmes P

    更新日期:2006-11-01 00:00:00

  • Communal responsibility: a history of health collectives in Australia.

    abstract::Healthcare encompasses multiple discourses to which health professionals, researchers, patients, carers and lay individuals contribute. Networks of patients and non-professionals often act collectively to build capacity, enhance access to resources, develop understanding and improve provision of care. This article exp...

    journal_title:Internal medicine journal

    pub_type: 历史文章,杂志文章

    doi:10.1111/imj.14426

    authors: Grant MP,Philip JAM,Deliens L,Komesaroff PA

    更新日期:2019-09-01 00:00:00

  • Population-based analysis of radiotherapy and chemotherapy treatment in the last month of life within regional Australia.

    abstract:BACKGROUND:Cancer treatment near end of life is not likely to add meaningful benefit and minimising intervention rates has been promoted as an indicator of quality of care. Population-based analysis of treatment allows comparative analysis of treatment rates and provides insight into patterns of care. AIMS:To report a...

    journal_title:Internal medicine journal

    pub_type: 杂志文章

    doi:10.1111/imj.14377

    authors: Pitson G,Matheson L,Garrard B,Eastman P,Rogers M

    更新日期:2020-05-01 00:00:00