当前位置： SCI文献检索 > INTERNAL MEDICINE JOURNAL期刊下所有文献 > Seasonal recurrence of food bolus obstruction in eosinophilic esophagitis.

Seasonal recurrence of food bolus obstruction in eosinophilic esophagitis.

Abstract：

BACKGROUND:Eosinophilic esophagitis (EoE) is a newly recognised condition that is apparently increasing in prevalence, and the aetiology is poorly understood. The role of aeroallergens in EoE is controversial, given the success of dietary therapy. Massive aeroallergen exposure leading to food bolus obstruction events (FBOE) has been described, and the diagnosis of EoE by esophageal biopsy noted to be more common in the pollen season according to previous case series. AIM:To determine if a seasonal variation and a geographical variation occurred in EoE presenting as FBOE in adults, and to track the prevalence of FBOE and EoE over time. METHOD:A retrospective case-control study analysis was performed from January 2002 to January 2012 to identify all FBOE in adults presenting to five tertiary hospitals in Melbourne, Australia. Endoscopy, histopathological reports, case notes and blood tests were examined, and postcodes recorded. Records of pollen counts were obtained. Cases were defined according to esophageal biopsy and grouped based on month of diagnosis. All other causes of FBOE served as controls. RESULTS:One thousand, one hundred and thirty-two FBOE were identified. Biopsies were only performed in 278 of these cases, and 85 patients were found to have EoE after biopsy. Patients with EoE were younger (mean age 38 years, range 18-72) compared with those with alternative diagnosis (mean age 64.4 range 22-92), more likely to be male (M : F = 4:1 compared with 1.68:1 ) and had a higher eosinophil count in venous blood. Overall no seasonality was demonstrated in FBOE secondary to any diagnosis, although the six cases of recurrent FBOE secondary to EoE mainly occurred in the grass pollen season in subsequent years. FBOE cases were evenly distributed throughout metropolitan Melbourne irrespective of population density. EoE as a percentage of FBOE increased over time. CONCLUSION:Seasonal aeroallergens may be important for a subgroup of patients with EoE presenting as recurrent FBOE. Esophageal biopsies are performed in a minority of patients, representing a significant departure from ideal management and contributing to recurrent unnecessary FBOE. EoE is an increasingly important cause of FBOE.

journal_name

Intern Med J

journal_title

Internal medicine journal

authors

Philpott HL,Nandurkar S,Thien F,Bloom S,Lin E,Goldberg R,Boyapati R,Finch A,Royce SG,Gibson PR

doi

10.1111/imj.12790

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

939-43

issue

eissn

1444-0903

issn

1445-5994

journal_volume

pub_type

杂志文章,多中心研究

在线工具

Seasonal recurrence of food bolus obstruction in eosinophilic esophagitis.