Treatment with unfunded drugs in oncology: the impact of access programmes and clinical trials.

abstract：AIM:Premature discontinuation of antiplatelet therapy is an independent predictor of late stent thrombosis. We sought to determine the prevalence and predictors of premature discontinuation of antiplatelet therapy after drug-eluting stent implantation among patients in Asia. METHODS:A total of 207 consecutive patients...

journal_title：Internal medicine journal

authors： Poh CL,Chan MY,Lau C,Teo SG,Low AF,Tan HC,Lee CH

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The short Synacthen test is widely used to assess the hypothalamus pituitary adrenal axis in the outpatient setting. In the inpatient setting however, technical difficulties to adhere to the protocol may pose a challenge for using this test. AIMS:In this study we attempted to find the most suitable basal se...

journal_title：Internal medicine journal

authors： Tolkin L,Vidberg M,Munter G

更新日期：2020-08-24 00:00:00

abstract：:Decompressive hemicraniectomy (DHC) has been shown to reduce mortality in malignant middle cerebral artery (MCA) infarction. Our primary objective was to compare 1-year mortality between patients receiving DHC for malignant MCA infarction at our institution based on hospital of origin. We retrospectively reviewed the ...

journal_title：Internal medicine journal

authors： Smyth D,Weatherall M,Rosemergy I,Woon K,Lanford J

更新日期：2018-10-01 00:00:00

abstract：AIM:To carry out an audit of the appropriateness of fresh-frozen plasma (FFP) and platelets (Plt) transfusion with reference to the Australian National Health and Medical Research Council/Australian Society of Blood Transfusion Clinical Practice Guidelines, and to assess the impact of a self-educating transfusion reque...

journal_title：Internal medicine journal

authors： Hui CH,Williams I,Davis K

更新日期：2005-05-01 00:00:00

abstract：:The insulin tolerance test is considered the gold standard for assessing the hypothalamic-pituitary-adrenal and growth hormone (GH) axes, but its use varies considerably among different endocrine units. We recommend using the insulin tolerance test to assess the hypothalamic-pituitary-adrenal axis within 3 months of p...

journal_title：Internal medicine journal

authors： Sarlos S,Inder WJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:In 2004, the Pharmaceutical Benefits Scheme (PBS) listed infliximab as a subsidised treatment for ankylosing spondylitis (AS). Eligibility to receive this treatment for AS involved fulfilling several criteria. AIM:To examine the medical literature concerning response to tumor necrosis factor (TNF)-alpha inh...

journal_title：Internal medicine journal

authors： Smith MD,Ahern MJ

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Peptic ulcer disease risk factors have changed, as has the impact of treatment on morbidity and mortality. Recent data on clinical presentation and outcome are sparse in Australia. AIM:To determine the characteristics and outcome of patients presenting with a bleeding peptic ulcer to a tertiary referral cen...

journal_title：Internal medicine journal

authors： Halland M,Young M,Fitzgerald MN,Inder K,Duggan JM,Duggan A

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Acute coronary syndromes (ACS) management is now well informed by guidelines extrapolated from clinical trials. However, most of these data have been acquired outside the local context. We sought to describe the current patterns of ACS care in Australia. METHODS:The Acute Coronary Syndrome Prospective Audit...

journal_title：Internal medicine journal

authors： Chew DP,Amerena J,Coverdale S,Rankin J,Astley C,Brieger D

更新日期：2007-11-01 00:00:00

abstract：:Antifungal prophylaxis can be recommended in patients undergoing induction chemotherapy for acute myeloid leukemia and treatment for grade 2 or greater or chronic extensive graft versus host disease. The evidence for prophylaxis is less clear in other clinical settings although certain groups such as patients with pro...

journal_title：Internal medicine journal

authors： Slavin MA,Heath CH,Thursky KA,Morrissey CO,Szer J,Ling LM,Milliken ST,Grigg AP

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Cancer treatment near end of life is not likely to add meaningful benefit and minimising intervention rates has been promoted as an indicator of quality of care. Population-based analysis of treatment allows comparative analysis of treatment rates and provides insight into patterns of care. AIMS:To report a...

journal_title：Internal medicine journal

authors： Pitson G,Matheson L,Garrard B,Eastman P,Rogers M

更新日期：2020-05-01 00:00:00

abstract：:The annual Leonard Ball Orations illustrate changing perspectives in Australia over 30 years on medical and social effects of misuse of alcohol and other substances. The first oration, in 1968, examined causal factors in the context of 'agent', 'purveyor' and 'host' and provided themes for subsequent orators. In regar...

journal_title：Internal medicine journal

authors： Mackay IR

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Several epidemiological studies have suggested a positive association of coronary heart disease with both Helicobacter pylori and Chlamydia pneumoniae infection. The issue has been difficult to resolve because of the potential impact of several confounding factors, in particular, socioeconomic status for H. ...

journal_title：Internal medicine journal

authors： Fraser AG,Scragg RK,Cox B,Jackson RT

更新日期：2003-07-01 00:00:00

abstract：:Almost everywhere in the body there are phospholipids, not only comprising the lipid bilayer of membranes, but also in the free state. What is seldom appreciated, except in respirology, is that these 'free' phospholipids are unusual in that many are highly surface active. Surface activity is a property of certain subs...

journal_title：Internal medicine journal

authors： Hills BA

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:The reported risk of depression in patients with hypomagnesaemia is controversial. AIM:The objective of this meta-analysis was to assess the association between depression and hypomagnesaemia. METHODS:A literature search was performed using MEDLINE, EMBASE, Cochrane Database and clinicaltrials.gov from inc...

journal_title：Internal medicine journal

authors： Cheungpasitporn W,Thongprayoon C,Mao MA,Srivali N,Ungprasert P,Varothai N,Sanguankeo A,Kittanamongkolchai W,Erickson SB

更新日期：2015-04-01 00:00:00

abstract：AIMS:Low molecular weight heparins (LMWH) permit safe and effective treatment of uncomplicated deep venous thrombosis (DVT) at home. The aim of this study was to evaluate the cost minimization, cost shifting and patient satisfaction associated with at-home DVT treatment using the LMWH enoxaparin, compared to standard i...

journal_title：Internal medicine journal

authors： Smith BJ,Weekley JS,Pilotto L,Howe T,Beven R

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemoradiation therapy (CRT) is standard of care treatment for locally advanced rectal cancer (LARC). A pathologic complete response (pCR) following CRT is an early indicator of treatment benefit and associated with excellent survival outcomes. As capecitabine replaces infusional 5-fluorouracil (...

journal_title：Internal medicine journal

authors： Loft M,Wong HL,Kosmider S,Lee M,Tie J,Wong R,Jones IT,Croxford M,Steel M,Faragher I,Guerrieri M,Christie M,Gibbs P

更新日期：2020-09-08 00:00:00

abstract：BACKGROUND/AIM:This study aimed to report the clinical characteristics and outcomes of Australian patients treated with eculizumab for atypical haemolytic uraemic syndrome (aHUS). METHODS:A retrospective cohort study was undertaken of all patients in Australia treated with eculizumab provided in a compassionate access...

journal_title：Internal medicine journal

authors： Mallett A,Hughes P,Szer J,Tuckfield A,Van Eps C,Cambell SB,Hawley C,Burke J,Kausman J,Hewitt I,Parnham A,Ford S,Isbel N

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Low socioeconomic status is associated with cardiovascular diseases, and an association with atrial fibrillation (AF) could guide screening. AIM:To investigate if indices of advantage/disadvantage (IAD), index of education/occupation (IEO) and index of economic resources were associated with incident AF, in...

journal_title：Internal medicine journal

authors： Ramkumar S,Ochi A,Yang H,Nerlekar N,D'Elia N,Potter EL,Murray IC,Nattraj N,Wang Y,Marwick TH

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:  According to the International Prognostic Scoring System (IPSS), sole +8 is categorized as intermediate cytogenetic subgroup. But as some myelodysplastic syndrome (MDS) patients with +8 perhaps progress quickly to acute leukaemia and have shorter survival, some reports have suggested that +8 should be cate...

journal_title：Internal medicine journal

authors： Ma Y,Wang X,Xu X,Lin G

更新日期：2010-10-01 00:00:00

abstract：:Non-invasive ventilation refers to a number of respiratory support strategies commonly used in critical care settings. This paper describes the principles of non-invasive ventilation, the practicalities of its use and the evidence for its use in a number of common acute conditions. ...

journal_title：Internal medicine journal

authors： Cross AM

更新日期：2012-10-01 00:00:00

abstract：:Based on the number of new cases (incidence), non-Hodgkin lymphoma is an increasingly common cancer in Australia and many developed countries. Until recently, mortality trends have been stable or slightly increasing. However, since the year 2000, mortality has decreased every year by an average of 5.1% per year (95% c...

journal_title：Internal medicine journal

authors： Coory M,Gill D

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Delirium is common in hospitalised patients but its epidemiology remains poorly characterised. AIMS:To test the hypothesis that patient demographics, clinical phenotype, management and outcomes of patient with delirium in hospital ward patients differ from intensive care unit (ICU) patients. METHODS:Retros...

journal_title：Internal medicine journal

authors： Canet E,Amjad S,Robbins R,Lewis J,Matalanis M,Jones D,Bellomo R

更新日期：2019-12-01 00:00:00

abstract：:Thrombotic microangiopathy (TMA) arises in a variety of clinical circumstances with the potential to cause significant dysfunction of the kidneys, brain, gastrointestinal tract and heart. TMA should be considered in all patients with thrombocytopenia and anaemia, with an immediate request to the haematology laboratory...

journal_title：Internal medicine journal

authors： Fox LC,Cohney SJ,Kausman JY,Shortt J,Hughes PD,Wood EM,Isbel NM,de Malmanche T,Durkan A,Hissaria P,Blombery P,Barbour TD

更新日期：2018-06-01 00:00:00

abstract：:The author, a physician in late middle age reflects on his own medical career, the aging of those who have taught him and also of those whom he has taught. He describes the sense of ennui and déjà vu. The things that seemed important as a younger doctor seem less important. He has adopted a different paradigm and has ...

journal_title：Internal medicine journal

authors： Allen RK

更新日期：2006-12-01 00:00:00

abstract：:The phenomenon of addiction is complex, although its expression clinically is relatively straightforward. There is a series of neurophysiological changes that mediate changes in the mesolimbic and mesocortical systems which in turn lead to disturbances in reward mechanisms. These then act to perpetuate the cycle of in...

journal_title：Internal medicine journal

authors： Foy A

更新日期：2007-05-01 00:00:00

abstract：:Influenza vaccination is an important preventative health measure. A significant proportion of general medical inpatients meets indications for annual inactivated influenza vaccination (IIV), as recommended by the Australian National Immunisation Programme. This study explores opportunities to provide IIV to eligible ...

journal_title：Internal medicine journal

authors： Zaman FY,Nagalingam V,Wong C,Khu YL,Teng HWG,Janardan J,Ritchie E,Cheng AC,Aung AK

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Cigarette smoking prevalence has been declining over decades in Western countries especially in higher socioeconomic groups. Employees of Australian hospitals span the socioeconomic spectrum, but there are few data on smoking prevalence from these workplaces. Because smoking is a health hazard, some argue th...

journal_title：Internal medicine journal

authors： Jones TE,Williams J

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Anticoagulants are recommended to prevent cardioembolic stroke in most patients with atrial fibrillation (AF). Management errors with anticoagulation and use of aspirin instead of anticoagulants have been documented worldwide, especially with vitamin K antagonists. We assessed the rate of anticoagul...

journal_title：Internal medicine journal

authors： Wong E,Aaqib M,Thijs V

更新日期：2020-12-21 00:00:00

abstract：BACKGROUND:There are no sufficient data available on the use of febuxostat in patients undergoing dialysis. AIM:We investigated the efficacy and tolerability of febuxostat in gout patients on dialysis. METHODS:We retrospectively reviewed clinical and laboratory data available from a referral center from January 2012 ...

journal_title：Internal medicine journal

authors： Choi SY,Choi SW,Lee S,So MW,Oh JS,Lim DH

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:The effects of empagliflozin on cardiac structure and function are not known. AIMS:To examine the changes in cardiac structure and function following the addition of empagliflozin in patients with type 2 (T2D) diabetes using cardiac magnetic resonance (CMR) imaging. METHODS:Twenty patients attending a spec...

journal_title：Internal medicine journal

authors： Cohen ND,Gutman SJ,Briganti EM,Taylor AJ

更新日期：2019-08-01 00:00:00