The efficacy and tolerability of febuxostat in gout patients on dialysis.

abstract：:Individualised drug dosing has been shown to improve patient outcomes and reduce adverse drug events. One method of individualised medicine is the Bayesian approach, which uses prior information about how the population responds to therapy, to inform clinicians about how a specific individual is responding to their cu...

journal_title：Internal medicine journal

authors： Donagher J,Martin JH,Barras MA

更新日期：2017-05-01 00:00:00

abstract：:The Australian National Chronic Obstructive Pulmonary Disease (COPD) guidelines recommend that inhaled corticosteroids (ICS) be reserved for patients with a post-bronchodilator forced expiratory volume in 1 s (FEV1 ) less than 50% predicted and those who experience ≥2 exacerbations in 12 months. In total, 707 COPD pat...

journal_title：Internal medicine journal

authors： Harrison A,Borg B,Thompson B,Hew M,Dabscheck E

更新日期：2017-11-01 00:00:00

abstract：:This paper uses a case example to review the current legal status of advance directives, as well as their ethical rationale. We draw attention to ongoing efforts to institutionalize advance directives, and to some of the tractable and intractable reasons why advance directives are ineffective. We then introduce the co...

journal_title：Internal medicine journal

authors： Jordens C,Little M,Kerridge I,McPhee J

更新日期：2005-09-01 00:00:00

abstract：AIMS:Our primary aim was to determine the rate of overseas travel in immunocompromised individuals attending appropriate clinics at an Australian tertiary care hospital. We also aimed to characterise health-seeking behaviour prior to travel and investigated sources of pre-travel advice, compared travel patterns and act...

journal_title：Internal medicine journal

authors： Bialy C,Horne K,Dendle C,Kanellis J,Littlejohn G,Ratnam I,Woolley I

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Off-label use of rituximab in lupus nephritis is reported to be beneficial. While the optimal dose is unknown, the regimen of four intravenous doses of 375 mg/m(2) is commonly employed, despite expense and potential side-effects. AIM:To investigate the response to single-dose rituximab, added to standard co...

journal_title：Internal medicine journal

authors： Kotagiri P,Martin A,Hughes P,Becker G,Nicholls K

更新日期：2016-08-01 00:00:00

abstract：:Carbimazole is a drug that is widely used for hyperthyroid disorders, such as Graves' disease. Agranulocytosis is a rare idiosyncratic adverse reaction to the drug which is potentially fatal. This report describes a patient with a history of successfully treated pyoderma gangrenosum, who developed agranulocytosis 3 we...

journal_title：Internal medicine journal

authors： Yip G,Ekinci E,Lee ST,Jerums G,Grossmann M

更新日期：2010-04-01 00:00:00

abstract：:Chronic lead exposure is recognized as a potential cause of hyperuricaemia, kidney damage and hypertension. The fascinating story of lead poisoning and nephrotoxicity illustrates the utility of descriptive studies in the early elucidation of a new disease entity. The pursuit towards understanding lead nephropathy is p...

journal_title：Internal medicine journal

authors： Chow KM,Liu ZC,Szeto CC

更新日期：2006-10-01 00:00:00

abstract：:These consensus guidelines provide recommendations for the safe handling of monoclonal antibodies. Definitive recommendations are given for the minimum safe handling requirements to protect healthcare personnel. The seven recommendations cover: (i) appropriate determinants for evaluating occupational exposure risk; (i...

journal_title：Internal medicine journal

authors： Alexander M,King J,Bajel A,Doecke C,Fox P,Lingaratnam S,Mellor JD,Nicholson L,Roos I,Saunders T,Wilkes J,Zielinski R,Byrne J,MacMillan K,Mollo A,Kirsa S,Green M

更新日期：2014-10-01 00:00:00

abstract：:This paper examines the differences between clinical and public health ethics and provides several examples of contemporary public health challenges that pose ethical questions. The relations among ethics, rights and obligations are explored, because public health philosophers propose these as different ways for publi...

journal_title：Internal medicine journal

authors： Leeder SR

更新日期：2004-07-01 00:00:00

abstract：:Climate change is unequivocal. The fourth assessment report of the Intergovermental Panel on Climate Change has recently projected that global average surface temperature will increase by 1.1 to 6.4 degrees C by 2100. Anthropogenic warming during the twenty-first century would be much greater than that observed in the...

journal_title：Internal medicine journal

authors： Tong S,Mackenzie J,Pitman AJ,FitzGerald G,Nicholls N,Selvey L

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:High baseline level of soluble suppression of tumourigenicity 2 (sST2) was an independent predictor of cardiovascular death and heart failure in ST-segment elevation myocardial infarction (STEMI). AIMS:To investigate the value of serum sST2 baseline levels in predicting myocardial reperfusion in patients wi...

journal_title：Internal medicine journal

authors： Bai S,Liu H,Wu H,Wang X,Li R,Li X,Li X,Zhang L,Chen T,Du R

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Acute coronary syndromes (ACS) management is now well informed by guidelines extrapolated from clinical trials. However, most of these data have been acquired outside the local context. We sought to describe the current patterns of ACS care in Australia. METHODS:The Acute Coronary Syndrome Prospective Audit...

journal_title：Internal medicine journal

authors： Chew DP,Amerena J,Coverdale S,Rankin J,Astley C,Brieger D

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Unrelated umbilical cord blood has emerged as an alternative stem cell source for allogeneic transplantation for patients with haematological malignancies, but in adults is limited by the low number of stem cells present in banked cord blood units. We report our experience with double cord blood transplants ...

journal_title：Internal medicine journal

authors： Bradstock K,Hertzberg M,Kerridge I,Svennilson J,George B,McGurgan M,Huang G,Antonenas V,Gottlieb D

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:The role of brentuximab peri-allogeneic transplantation in patients with relapsed and/or refractory CD30 positive lymphomas remains poorly defined. AIM:To assess the outcome of use of brentuximab as a bridge to allogeneic stem cell transplantation (SCT) in patient with relapsed/refractory CD30+ classic Hodg...

journal_title：Internal medicine journal

authors： Mediwake H,Morris K,Curley C,Butler J,Kennedy G

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The NSW Clinical Excellence commission introduced the "Between the Flags" program in response to the death of a young patient as a system wide approach for early detection and management of the deteriorating patient in all 242 NSW hospitals. The impact of BTF implementation on the 35 larger hospitals with IC...

journal_title：Internal medicine journal

authors： Bhonagiri D,Lander H,Green M,Straney L,Jones D,Pilcher D

更新日期：2020-03-04 00:00:00

abstract：AIM:Premature discontinuation of antiplatelet therapy is an independent predictor of late stent thrombosis. We sought to determine the prevalence and predictors of premature discontinuation of antiplatelet therapy after drug-eluting stent implantation among patients in Asia. METHODS:A total of 207 consecutive patients...

journal_title：Internal medicine journal

authors： Poh CL,Chan MY,Lau C,Teo SG,Low AF,Tan HC,Lee CH

更新日期：2011-08-01 00:00:00

abstract：:Neuroimaging in dementia has focused on documenting any burden of vascular disease or excluding any reversible intracranial pathology. We review the use of computed tomography to examine for medial temporal lobe atrophy in dementia and compare this with a case series of such measurements from our memory clinic. Measur...

journal_title：Internal medicine journal

authors： Rose M,Scharf S

更新日期：2008-02-01 00:00:00

abstract：:ABSTRACT Treatment of invasive fungal infections is increasingly complex. Amphotericin B deoxycholate has long been the mainstay of treatment. However, there has been increasing recognition of both the propensity for nephro-toxicity in haematology, transplant and intensive care patients as well as its adverse impact o...

journal_title：Internal medicine journal

authors： Slavin MA,Szer J,Grigg AP,Roberts AW,Seymour JF,Sasadeusz J,Thursky K,Chen SC,Morrissey CO,Heath CH,Sorrell T

更新日期：2004-04-01 00:00:00

abstract：:There is accumulating evidence that point-of-care delivery of clinical information such as evidence-based medicine, practice guidelines and drug information can streamline clinical practice and reduce preventable errors. In Australia, hospital-based physicians have -generally been slow to fully use these resources to ...

journal_title：Internal medicine journal

authors： Wilcox RA,Whitham EM

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:High concentration oxygen is commonly administered during acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The aim of this study was to determine the association between oxygen, severity markers and poor outcomes in AECOPD. METHODS:In an audit of patients with AECOPD arriving by ambula...

journal_title：Internal medicine journal

authors： Wijesinghe M,Perrin K,Healy B,Hart K,Clay J,Weatherall M,Beasley R

更新日期：2011-08-01 00:00:00

abstract：:Staphylococcal infections are a common and significant clinical problem in medical practice. Most strains of Staphylococcus aureus are now resistant to penicillin, and methicillin-resistant strains of S. aureus (MRSA) are common in hospitals and are emerging in the community. Penicillinase-resistant penicillins (flucl...

journal_title：Internal medicine journal

authors： Rayner C,Munckhof WJ

更新日期：2005-12-01 00:00:00

abstract：:In Australia, mutations in epidermal growth factor mutations (EGFR) occur in 15% of patients diagnosed with non-small-cell lung cancer and are found with higher frequency in female, non-smokers of Asian ethnicity. Activating mutations in the EGFR gene are rarely described in SCLC. We present two cases of de novo EGFR ...

journal_title：Internal medicine journal

authors： Thai A,Chia PL,Russell PA,Do H,Dobrovic A,Mitchell P,John T

更新日期：2017-09-01 00:00:00

abstract：:Here we report the case of a 69-year-old Chinese Han woman who presented with liver cirrhosis, diabetes mellitus, skin hyperpigmentation, hyperferritinaemia and high transferrin saturation. Subsequent genetic analyses identified a novel heterozygous mutation (p.Cys326Phe) in the SLC40A1 gene. This is the first report ...

journal_title：Internal medicine journal

authors： Chen SR,Yang LQ,Chong YT,Jie YS,Wu YK,Yang J,Lin GL,Li XH

更新日期：2015-06-01 00:00:00

abstract：:The enthusiasm for evidence-based medicine (EBM) has not been accompanied by the same success in bridging the gap between theory and practice. This paper advances the hypothesis that the phenomenon psychologists call hypocognition may hinder the development of EBM. People tend to respond to frames rather than to facts...

journal_title：Internal medicine journal

authors： Mariotto A

更新日期：2010-01-01 00:00:00

abstract：:Radical market-oriented health reforms in New Zealand in the early 1990s failed to deliver key financial targets, resulted in unnecessary patient deaths, adversely affected public healthcare services, induced serious tensions between clinicians and managers and encouraged a predisposition to private healthcare. A more...

journal_title：Internal medicine journal

authors： Nicholls MG,Frampton CM,Bagshaw PF

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:In Australia, antimicrobial stewardship programmes are a compulsory component of hospital accreditation. Good documentation around anti-microbial prescribing aids communication and can improve prescribing practice in environments with multiple decision makers. AIM:This study aims to develop and implement an...

journal_title：Internal medicine journal

authors： Chaves NJ,Ingram RJ,MacIsaac CM,Buising KL

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Timor-Leste is one of the poorest countries in the world. The East Timor Hearts Fund is a charitable organisation involving Australian cardiologists providing outreach screening and access to cardiac interventions. AIMS:To assess ten years of clinical volume, demographics and patient outcomes. Our intention...

journal_title：Internal medicine journal

authors： Paratz ED,Mock N,Gutman SJ,Horton A,Creati L,Appelbe A,Eggleton S,Kushwaha V,da Silva Almeida IT,Monteiro A,Bayley N

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Populations with increased skin pigmentation who have migrated to countries of high latitude are at increased risk of low vitamin D. This study aimed to determine the prevalence of low vitamin D among the refugee population arriving in New Zealand. METHODS:An audit of all refugees arriving at the national r...

journal_title：Internal medicine journal

authors： Wishart HD,Reeve AM,Grant CC

更新日期：2007-12-01 00:00:00

abstract：:A 75-year-old man of Fijian-Indian extraction complained of a 3-year history of progressive right knee pain and stiffness which were limiting his mobility. On examination, multiple hard nodules were palpable in the popliteal fossa and along the path of the quadriceps tendon. The joint line was not tender, knee flexion...

journal_title：Internal medicine journal

authors： Langguth DM,Klestov A,Denaro C

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:IgE-mediated allergy to the wheat protein omega-5-gliadin (O5G) is associated with wheat-dependent exercise-induced anaphylaxis (WDEIA), where exercise acts as a cofactor, triggering anaphylaxis after wheat ingestion. The wider application of O5G-specific IgE (sIgE) testing has revealed that the manifestatio...

journal_title：Internal medicine journal

authors： Le TA,Al Kindi M,Tan JA,Smith A,Heddle RJ,Kette FE,Hissaria P,Smith WB

更新日期：2016-06-01 00:00:00