Abstract:
BACKGROUND:Several epidemiological studies have suggested a positive association of coronary heart disease with both Helicobacter pylori and Chlamydia pneumoniae infection. The issue has been difficult to resolve because of the potential impact of several confounding factors, in particular, socioeconomic status for H. pylori and smoking for C. pneumoniae. METHODS:A case-control study was carried out of 341 patients with a recent myocardial infarction (MI) and 831 community controls who had serology tests for H. pylori and C. pneumoniae (selected from a total study number of 1745 subjects). Individuals of Pacific Island or Maori ethnicity were excluded because they were infrequent. RESULTS:H. pylori seropositivity was associated with increasing age (P < 0.001) and lower household income (P = 0.0003) but not with gender, smoking status or alcohol intake. H. pylori was associated with lower high-density lipoprotein cholesterol (P = 0.007) and a higher body mass index (P = 0.007). The overall seropositivity for H. pylori was 41.6% for patients with MI and 34.5% for age and sex-matched population controls. The odds ratio was 1.34 (95% confidence interval (CI): 1.00-1.80; P = 0.038) after adjusting for age and sex. C. pneumoniae seropositivity was significantly associated with male sex, younger age (P = 0.03) and smoking status (P = 0.004) but not associated with household income or any other measured risk factor for coronary heart disease. The overall seropositivity for C. pneumoniae was 51.2% for patients with recent MI and 43.5% for controls. After adjusting for age and sex, the odds ratio was 1.24 (95%CI: 0.95-1.62; P = 0.11). Subgroup analysis showed no clear pattern within different age groups. In particular, the odds ratio for H. pylori seropositivity in younger subjects (aged 35-49 years) was similar to the overall group (1.38; 95%CI: 0.83-2.29). CONCLUSION:The association between H. pylori or C. pneumoniae seropositivity and coronary heart disease was significant but may not indicate a causal association.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Fraser AG,Scragg RK,Cox B,Jackson RTdoi
10.1046/j.1445-5994.2003.00349.xkeywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
267-72issue
7eissn
1444-0903issn
1445-5994pii
349journal_volume
33pub_type
杂志文章abstract:BACKGROUND:The aim of the study was to assess the structural and functional effects of autologous stem cell transplantation (ASCT) on scleroderma finger clawing. METHODS:Using photocopies of hands of five scleroderma patients who underwent ASCT using photocopies of hands. Functional assessments used a standardized que...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01593.x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Stroke neurologists, vascular surgeons, interventional neuroradiologists and interventional cardiologists have embraced carotid angioplasty and stenting (CAS) because of potential advantages over carotid endarterectomy (CEA). At Austin Health, a multidisciplinary neuro-interventional group was formed to stan...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2010.02285.x
更新日期:2011-11-01 00:00:00
abstract::In this essay, I reflect on my experience as a multiple sclerosis patient in order to identify some of the unique challenges that chronic disability poses in the physician-patient relationship. I suggest that it is important to broaden the goals of the clinical encounter to incorporate personal (as opposed to simply b...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2004.00700.x
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:There is a global concern that physician-researchers are 'a dying breed'. Recent studies of clinical career choices of Australian medical students and doctors have signalled the rising age of medical graduates, generational shifts in work-life attitudes and increased proportion of female graduates. There are...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14086
更新日期:2019-02-01 00:00:00
abstract::Advanced heart failure represents a small proportion of patients with heart failure that possess high-risk features associated with high hospital readmission rates, significant functional impairment and mortality. Identification of those who have progressed to, or are near a state of advanced heart failure should prom...
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pub_type: 杂志文章,评审
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更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:In Australia medical practitioners are often required to assume the responsibility for assessing fitness to drive. However the clinical practice, knowledge and attitudes of doctors with regards to this responsibility are unknown. The aim of this study was to determine the clinical practice, knowledge and att...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01337.x
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:Pulmonary embolism (PE) is associated with significant morbidity and mortality. PE is a heterogeneous entity that causes a wide variety of clinical presentations, making it imperative to establish which clinical symptoms, signs and biomarkers can influence the pretest probability of PE to aid clinicians and ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13596
更新日期:2018-01-01 00:00:00
abstract::5-aminosalicylates (5-ASA) remain an important strategy in the induction and maintenance of remission of inflammatory bowel diseases especially in ulcerative colitis. The prototypical drug of this class, sulfasalazine is generally well tolerated with severe hypersensitivity reactions and hepatotoxicity also described ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12240
更新日期:2013-10-01 00:00:00
abstract:AIMS:To survey the practice among gastroenterologists in Australia relating to screening for latent infections and vaccination of patients with inflammatory bowel disease prior to treatment with tumour necrosis factor alpha (TNF-α) inhibitors. METHODS:A structured 15 question electronic survey was advertised to gastro...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.02114.x
更新日期:2011-06-01 00:00:00
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journal_title:Internal medicine journal
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更新日期:2010-04-01 00:00:00
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更新日期:2020-10-01 00:00:00
abstract::We review the aetiology of scleroderma from an epidemiological perspective examining genetic, environmental and stochastic risk factors. The presence of familial clustering (but with low twin concordance) suggests a genetic contribution, and this has been confirmed with recent candidate gene and genome-wide associatio...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2011.02706.x
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Inequalities in access to renal services and acute care for rural and remote populations in Australia have been described but not quantified. AIM:To describe: the coverage of renal disease management services in rural and remote Australia; and the characteristics of patients who had an aeromedical retrieval...
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更新日期:2020-08-01 00:00:00
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doi:10.1111/imj.12376
更新日期:2014-04-01 00:00:00
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更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/imj.14186
更新日期:2019-07-01 00:00:00
abstract:AIMS:To assess the level of evidence-based drug prescribing for acute coronary syndrome (ACS) at discharge from Western Australian (WA) hospitals and determine predictors of such prescribing in Aboriginal and non-Aboriginal patients. METHODS:All Aboriginal (2002-2004) and a random sample of non-Aboriginal (2003) hospi...
journal_title:Internal medicine journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/imj.12375
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The comparative effectiveness of biologic treatment regimens in a real world Australian population is unknown. AIM:To assess the effectiveness of biological disease-modifying anti-rheumatic drugs (bDMARD) as monotherapy or in combination with methotrexate and/or other conventional DMARD (cDMARD) for the tre...
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pub_type: 杂志文章,多中心研究
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更新日期:2018-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-11-01 00:00:00
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更新日期:2019-10-01 00:00:00
abstract::Young onset dementia (YOD), where symptoms of dementia have an onset before the age of 65, has become more prominent due to the population increase from the Baby Boomer generation. This clinical perspective examines key issues in the assessment, diagnosis and management of YOD. Challenges in the assessment and diagnos...
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pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2012.02895.x
更新日期:2012-10-01 00:00:00
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journal_title:Internal medicine journal
pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF), an important and treatable cause of ischaemic stroke, can occur as a sustained or a paroxysmal arrhythmia. Continuous cardiac rhythm monitoring (Holter monitoring) is often performed in stroke patients to identify paroxysmal AF, which is an indication for warfarin anti-coagulation i...
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pub_type: 杂志文章
doi:10.1111/j.1444-0903.2004.00589.x
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, enters human cells by binding of its viral protein to the aminopeptidase angiotensin-converting enzyme 2 (ACE2). This has led to speculation whether treatment with renin-angiotensin system (RAS) inhibitors was asso...
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pub_type: 杂志文章,meta分析
doi:10.1111/imj.15002
更新日期:2020-12-01 00:00:00
abstract:AIM:Bigge Park Centre (BPC) is a sexual health clinic located in a socially disadvantaged area in Southwest Sydney. This served as a retrospective clinical audit, documenting patient demographics, identifying factors associated with virological, immunological and discordant responses, evaluating the centre's ability in...
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pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The thiopurines azathioprine and 6-mercaptopurine are recommended for maintenance of remission in inflammatory bowel disease (IBD). Measurement of concentrations of the metabolites 6-thioguanine nucleotide and 6-methylmercaptopurine helps delineate interindividual variation in metabolism that may underlie va...
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pub_type: 杂志文章,多中心研究
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更新日期:2013-03-01 00:00:00
abstract::ABSTRACT Treatment of invasive fungal infections is increasingly complex. Amphotericin B deoxycholate has long been the mainstay of treatment. However, there has been increasing recognition of both the propensity for nephro-toxicity in haematology, transplant and intensive care patients as well as its adverse impact o...
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pub_type: 杂志文章,评审
doi:10.1111/j.1444-0903.2004.00541.x
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND AND AIM:Familial Mediterranean fever (FMF) is an autosomal recessive disease characterised by recurrent episodes of painful inflammation in the abdomen, chest or joints. The association between FMF and non-amyloid glomerulopathies are unusual. In this study, we describe our experiences and observations about...
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pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
abstract::Radical market-oriented health reforms in New Zealand in the early 1990s failed to deliver key financial targets, resulted in unnecessary patient deaths, adversely affected public healthcare services, induced serious tensions between clinicians and managers and encouraged a predisposition to private healthcare. A more...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14903
更新日期:2020-07-01 00:00:00