Carbimazole-induced agranulocytosis: does antineutrophil cytoplasmic antibody have a role?

Abstract:

:Carbimazole is a drug that is widely used for hyperthyroid disorders, such as Graves' disease. Agranulocytosis is a rare idiosyncratic adverse reaction to the drug which is potentially fatal. This report describes a patient with a history of successfully treated pyoderma gangrenosum, who developed agranulocytosis 3 weeks after commencement of carbimazole for Graves' disease. It may give credence to the theory that implicates antineutrophil cytoplasmic antibodies in the pathogenesis of agranulocytosis induced by antithyroid drugs.

journal_name

Intern Med J

authors

Yip G,Ekinci E,Lee ST,Jerums G,Grossmann M

doi

10.1111/j.1445-5994.2009.02143.x

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

300-3

issue

4

eissn

1444-0903

issn

1445-5994

pii

IMJ2143

journal_volume

40

pub_type

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