Abstract:
:Mitochondrial DNA (mtDNA) haplogroups are 'neutral polymorphisms' in the mtDNA genome, which have accumulated and persisted along maternal lineages as the human population has migrated worldwide. Three ethnically distinct lineages of human mtDNA populations have been identified: European, characterized by nine haplogroups H, I, J, K, T, U, V, W and X; African, characterized by superhaplogroup L and Asian, characterized by superhaplogroup M. We studied the prevalence of mtDNA haplogroups in participants of the Blue Mountains Eye Study, a large population-based survey of vision conducted between 1991 and 2000 of non-institutionalized permanent residents aged 49 years or older from two suburban postcode areas, west of Sydney, Australia. Total DNA isolated from either hair follicles or blood was available for 3377 of the 3509 participants (96.2%) to determine mtDNA haplogroups by polymerase chain reaction/restriction fragment length polymorphism analysis. Approximately 94.2% of samples could be assigned to one of the nine major European haplogroups, whereas a further 1.2% included the African (L) and Asian (M) superhaplogroups. The five principal haplogroups represented were H (42.9%), U (14.1%), J (10.7%), T (9.2%) and K (8.1%), which together included 85% of this population.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Manwaring N,Jones MM,Wang JJ,Rochtchina E,Mitchell P,Sue CMdoi
10.1111/j.1445-5994.2006.01118.xsubject
Has Abstractpub_date
2006-08-01 00:00:00pages
530-3issue
8eissn
1444-0903issn
1445-5994pii
IMJ1118journal_volume
36pub_type
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更新日期:2020-02-11 00:00:00
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更新日期:2010-04-01 00:00:00
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