Abstract:
:Clarithromycin is the most documented cytochrome P450 3A4 (CYP3A4) inhibitor to cause an adverse interaction with simvastatin. This particular case is of interest as rhabdomyolysis only occurred after an increase in the dose of clarithromycin. The patient developed raised cardiac biomarkers without any obvious cardiac issues, a phenomenon that has been linked to rhabdomyolysis previously. To date, there has been no reported effect of rhabdomyolysis on the structure and function of cardiac muscle. Clinicians need to be aware of prescribing concomitant medications that increase the risk of myopathy or inhibit the CYP3A4 enzyme. Our case suggests that troponin elevation could be associated with statin induced rhabdomyolysis, which may warrant further studies.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Page SR,Yee KCdoi
10.1111/imj.12464subject
Has Abstractpub_date
2014-07-01 00:00:00pages
690-3issue
7eissn
1444-0903issn
1445-5994journal_volume
44pub_type
杂志文章abstract:AIMS:We sought to assess a broad array of possible precipitants of acute coronary syndromes (ACS) and evaluate their association with detectable inflammatory activation. METHODS AND RESULTS:Within a case-crossover design, using a standardised questionnaire, interviews among 348 ST-elevation myocardial infarction (44%)...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2011.02583.x
更新日期:2012-10-01 00:00:00
abstract:AIM:To ascertain the prevalence of HER2/neu-positive early breast cancer (EBC), utilisation of adjuvant trastuzumab and incidence of cardiac toxicity in a community private hospital setting. METHODS:Prospective data collected by breast oncologist and surgeons in all women diagnosed with EBC at the Mount Hospital (MH) ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2011.02432.x
更新日期:2012-03-01 00:00:00
abstract::The insulin tolerance test is considered the gold standard for assessing the hypothalamic-pituitary-adrenal and growth hormone (GH) axes, but its use varies considerably among different endocrine units. We recommend using the insulin tolerance test to assess the hypothalamic-pituitary-adrenal axis within 3 months of p...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12011
更新日期:2013-01-01 00:00:00
abstract:AIMS:To survey the practice among gastroenterologists in Australia relating to screening for latent infections and vaccination of patients with inflammatory bowel disease prior to treatment with tumour necrosis factor alpha (TNF-α) inhibitors. METHODS:A structured 15 question electronic survey was advertised to gastro...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.02114.x
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:While medications may prolong life and prevent morbidity in older people, adverse effects of polypharmacy are increasingly recognised. As patients age and become frail, prescribing may be expected to focus more on symptom control and minimise potentially harmful preventive medication use that confer little b...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13526
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to describe the activity of a lung cancer multidisciplinary clinic (MDC) and examine whether this model of clinical practice results in adherence to best-practice guidelines. METHODS:Prospective analysis of demographic and clinical data in 431 patients referred to a lung cancer MDC...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2006.01237.x
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Stroke neurologists, vascular surgeons, interventional neuroradiologists and interventional cardiologists have embraced carotid angioplasty and stenting (CAS) because of potential advantages over carotid endarterectomy (CEA). At Austin Health, a multidisciplinary neuro-interventional group was formed to stan...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2010.02285.x
更新日期:2011-11-01 00:00:00
abstract::Undiagnosed pheochromocytoma in pregnancy is associated with significant maternal and foetal mortality. Herein we reviewed five cases of pheochromocytoma in pregnancy occurring during late pregnancy. The mean age at presentation was 30.6 years, and the gestational age ranged from 26 to 36 weeks. All patients had eleva...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12118
更新日期:2013-05-01 00:00:00
abstract::Depression, ischaemic heart disease and cerebrovascular disease are important causes of morbidity and are among the leading contributors to global health burden. These conditions often occur in the same patient, resulting in considerably greater effect on health than combinations of chronic diseases without depression...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2008.01794.x
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Clopidogrel is an antiplatelet drug increasingly used in the secondary prevention of atherosclerotic vascular events. Compared with aspirin, clopidogrel has marginal additional efficacy and similar safety, but carries a substantial price premium. It remains unclear whether its use is cost-effective. AIMS:(i...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2004.00697.x
更新日期:2004-12-01 00:00:00
abstract::Conventional teaching on the mechanisms and treatment of spontaneous pneumothorax is either obviously wrong or based on a misunderstanding of the natural history of the condition. Spontaneous pneumothorax is a generally benign, self-limiting condition where conservative management should be considered. If intervention...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2009.02155.x
更新日期:2010-03-01 00:00:00
abstract::Depression is the leading cause of non-fatal disease burden in Australia. Recently, increasing public recognition, together with the development of more integrated medical and psychological healthcare services has resulted in significant improvements. New pathophysiological models incorporate structural brain changes ...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2009.02016.x
更新日期:2009-11-01 00:00:00
abstract::Prior randomised studies of immunoglobulin replacement therapy have studied mixed populations with or without a history of infections. Immunoglobulin therapy is expensive and in limited supply suggesting that optimising patient selection is of value. In this retrospective study, infection history identified high-risk ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13205
更新日期:2016-10-01 00:00:00
abstract::The adverse fallout following the Royal Australasian College of Physician's (RACP) introduction to computer-based testing that was disrupted in the February 2018 examinations, aroused great sympathy for the candidates and perhaps rekindled worrying memories by the College fellowship. The RACP's entrance procedures hav...
journal_title:Internal medicine journal
pub_type: 历史文章,杂志文章
doi:10.1111/imj.14206
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:An adequately powered, double-blind, multisite, randomised controlled trial has shown no net clinical benefit for subcutaneous ketamine over placebo in the management of cancer pain refractory to combination opioid and co-analgesic therapy. The results of the trial were disseminated widely both nationally an...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12442
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The ACT Genetic Service at The Canberra Hospital evaluates the genetic risk of individuals for inherited diseases, and provides counselling and genetic testing where appropriate. AIM:To evaluate the current referral practice for patients with a personal and/or family history of breast and/or ovarian cancer,...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13357
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:IgE-mediated allergy to the wheat protein omega-5-gliadin (O5G) is associated with wheat-dependent exercise-induced anaphylaxis (WDEIA), where exercise acts as a cofactor, triggering anaphylaxis after wheat ingestion. The wider application of O5G-specific IgE (sIgE) testing has revealed that the manifestatio...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13091
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Teaching, mentoring and supervision (TMS) are fundamental skills with a specific commitment within the Royal Australasian College of Physicians (RACP) professional practice framework. The new basic training standards include 'use of appropriate educational techniques to facilitate the learning of peers, juni...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14935
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:Extreme heat is a public health priority in Australia with the health effects of cold poorly studied. A record-breaking cold winter prompted an institutional investigation into the epidemiology and outcomes of hypothermic presentations. AIMS:To describe the clinical and epidemiological characteristics of hy...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14308
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:High inflammatory bowel disease (IBD) rates have been reported in Australasia, but no state-wide studies have yet been performed. AIM:This study estimates the 1-year incidence and point prevalence of IBD in the state of Tasmania, Australia. It also reports clinical outcomes after 12 months of diagnosis in a...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14111
更新日期:2019-05-01 00:00:00
abstract::Healthcare encompasses multiple discourses to which health professionals, researchers, patients, carers and lay individuals contribute. Networks of patients and non-professionals often act collectively to build capacity, enhance access to resources, develop understanding and improve provision of care. This article exp...
journal_title:Internal medicine journal
pub_type: 历史文章,杂志文章
doi:10.1111/imj.14426
更新日期:2019-09-01 00:00:00
abstract:AIMS:To evaluate the effectiveness of a new locality-based integrated diabetes care service for people with Type 2 diabetes in an inner regional area. METHODS:A quasi-experimental evaluation comparing baseline and follow up clinical data collected from general practices and specialist services participating in an inte...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15211
更新日期:2021-01-20 00:00:00
abstract:BACKGROUND:Acute coronary syndromes (ACS) management is now well informed by guidelines extrapolated from clinical trials. However, most of these data have been acquired outside the local context. We sought to describe the current patterns of ACS care in Australia. METHODS:The Acute Coronary Syndrome Prospective Audit...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01435.x
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:There are no sufficient data available on the use of febuxostat in patients undergoing dialysis. AIM:We investigated the efficacy and tolerability of febuxostat in gout patients on dialysis. METHODS:We retrospectively reviewed clinical and laboratory data available from a referral center from January 2012 ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14776
更新日期:2020-02-11 00:00:00
abstract:BACKGROUND:In Australia, antimicrobial stewardship programmes are a compulsory component of hospital accreditation. Good documentation around anti-microbial prescribing aids communication and can improve prescribing practice in environments with multiple decision makers. AIM:This study aims to develop and implement an...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12539
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Peptic ulcer disease risk factors have changed, as has the impact of treatment on morbidity and mortality. Recent data on clinical presentation and outcome are sparse in Australia. AIM:To determine the characteristics and outcome of patients presenting with a bleeding peptic ulcer to a tertiary referral cen...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2010.02357.x
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:The international literature advocates for cancer screening in newly diagnosed patients with autoimmune myositis; however, there is no widely accepted consensus or guideline to outline the optimal cancer screening strategy and the evidence is currently insufficient to support any recommendation. AIM:Our stu...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13556
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The association between weather and severe acute respiratory syndrome (SARS) transmission in Beijing and Hong Kong in the 2003 epidemic was studied to examine the effect of weather on SARS transmission. METHODS:Pearson's correlation analyses and negative binomial regression analyses were used to quantify th...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01358.x
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Lung cancer accounts for significant morbidity and mortality worldwide. The effect of recent changes in demographics and management on outcomes in Australia has not been clearly defined. AIMS:To compare three consecutive lung cancer cohorts to evaluate emergent differences in diagnosis, management and morta...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13132
更新日期:2016-08-01 00:00:00
abstract::A patient with pulmonary arterial hypertension secondary to systemic sclerosis was successfully treated with sitaxentan prior to its worldwide withdrawal (because of hepatotoxicity concerns), but then ironically experienced acute hepatic dysfunction during substitute bosentan therapy, and was eventually stabilised on ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12007
更新日期:2012-12-01 00:00:00