Abstract:
BACKGROUND:Nanotechnology deals with the manufacturing of materials at the atomic and molecular scale. According to the National Nanotechnology Initiative, nanotechnology denotes those structures which are nearly in 1-100 nm size regime in at least one dimension. OBJECTIVE:Nanotechnology in drug delivery has been evidenced into nanocarriers that possess distinct properties both in vitro and in vivo, which may be used in targeting drugs to various diseases especially tumors. In the last few years, there has been a keen concern in the formulation of various new drug delivery systems employing nanotechnology. Different nanodevices or nanocarriers like liposomes, dendrimers, polymersomes, transfersomes, and nanoparticles etc. have been employed for the targeted drug delivery. CONCLUSION:This review summarizes the advances in nanocarriers in terms of their methods of preparation and potential applications especially in tumors.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Jain A,Kumari R,Tiwari A,Verma A,Tripathi A,Shrivastava A,Jain SKdoi
10.2174/1389450119666180131105822subject
Has Abstractpub_date
2018-01-01 00:00:00pages
1498-1518issue
13eissn
1389-4501issn
1873-5592pii
CDT-EPUB-88300journal_volume
19pub_type
杂志文章,评审abstract:BACKGROUND:Different clinical studies have given inconsistent results on whether the use of antipsychotics increases the risk of thromboembolism. In this paper, we reviewed all relevant literature to provide suggestions for clinical diagnosis and treatment. METHODS:PubMed, Web of Science, EMBASE, MEDLINE, Cochrane and...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666200422084414
更新日期:2020-01-01 00:00:00
abstract::Lung cancer kills approximately 1.3 million citizens in the world annually. The tyrosine kinase inhibitors (TKI) erlotinib and gefitinib are effective anti-tumor agents especially in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. The goal is to increase the potency of TKI in lung cancer p...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150107153609
更新日期:2016-01-01 00:00:00
abstract::In the context of OA disease, NF-kappaB transcription factors can be triggered by a host of stress-related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM degradation products. Activated NF-kappaB regulates the expression of many cytokines and chemokines, adhesion molecules, inflammat...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945010791011938
更新日期:2010-05-01 00:00:00
abstract::HIV-1 replicates by infecting new target cells either as cell-free viral particle or, much more efficiently, via cell-to-cell viral transmission. Cell-mediated viral spread, in which the infected cell directly transfers the viral particles to target cells via cell-cell contacts, in vitro is up to three orders of magni...
journal_title:Current drug targets
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更新日期:2015-08-25 00:00:00
abstract::It is well known that calorie restriction (CR) can retard the aging process in organisms ranging from yeast to non-human primates, and delay the onset of numerous age-related diseases including neurodegenerative disorders. Translation of the knowledge gained from CR research in animal models to disease prevention stra...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111007011281
更新日期:2010-10-01 00:00:00
abstract::Novel anti-vasculature strategies that are emerging for the treatment of cancer and for the inhibition of angiogenesis may be a promising new tool for the adjuvant therapy of malignant tumours. Over the last fifteen years, several reports have been published concerning the relationship between tumour progression and a...
journal_title:Current drug targets
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abstract::The last decade has witnessed the introduction of a large number of novel, molecularly targeted agents into the therapeutic armamentarium against diverse forms of cancer, including leukemia. Such agents include signal transduction, cell cycle, histone deacetylase, Hsp90, proteasome, and Bcl-2 family member inhibitors,...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2007-06-01 00:00:00
abstract::Recently, the presence of functional interaction between the opioid and cannabinoid system has been shown in various pharmacological responses. Although there is an increasing interest for the feasible therapeutic application of a co-administration of cannabinoids and opioids in some disorders (i.e. to manage pain, to...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2010-04-01 00:00:00
abstract::Target discovery using the molecular approach, as opposed to the more traditional systems approach requires the study of the cellular or biological process underlying a condition or disease. The approaches that are employed by the "bench" scientist may be genetic, genomic or proteomic and each has its rightful place i...
journal_title:Current drug targets
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doi:10.2174/1389450115666141120110323
更新日期:2015-01-01 00:00:00
abstract::Hepatic diseases are turning into one of the few diseases that cannot be effectively cured due to some reasons although various receptors existed in the liver. Currently, several passive targeting delivery systems have been used in the drug/gene delivery for the treatment of hepatic diseases. For example, Zinostatin s...
journal_title:Current drug targets
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更新日期:2014-06-01 00:00:00
abstract::RNA, as an intermediate in the production of every gene encoded protein and the genetic material of many pathogenic viruses, presents an attractive target for both biological and therapeutic manipulation. Despite its extensive involvement in living systems, its chemical diversity based on four units is relatively low ...
journal_title:Current drug targets
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更新日期:2002-06-01 00:00:00
abstract::Tuberculosis (TB) is an infectious disease caused by the pathogen Mycobacterium tuberculosis (M. tuberculosis), killing about two million people worldwide each year. An increase in the prevalence of drug-resistant strains of M. tuberculosis in the past decades has renewed focus on the development of new drugs that can...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
abstract::Recent progress in molecular biology has provided application of gene transfer methods in arthritis. Two clinical trails using ex vivo retrovirus mediated delivery of interleukin -1 receptor antagonist gene for rheumatoid arthritis has begun in USA and Germany. However, there are still many issues to be elucidated; on...
journal_title:Current drug targets
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更新日期:2003-11-01 00:00:00
abstract::Five programmed death-1/programmed death-ligand 1 (PD-L1) inhibitors are currently approved for the treatment of locally advanced or metastatic urothelial carcinoma of the bladder and the upper urinary tract. Following the FDA and EMA restrictions of first-line treatment with Atezolizumab and Pembrolizumab in platinum...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666200510015216
更新日期:2020-05-09 00:00:00
abstract::Multi-target drugs against particular multiple targets get better protection, resistance profiles and curative influence by cooperative rules of a key beneficial target with resistance behavior and compensatory elements. Computational techniques can assist us in the efforts to design novel drugs (ligands) with a prefe...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::The N-methyl-D-aspartate (NMDA) receptor is a major type of ionotropic glutamate receptor. Many studies have shown that NMDA receptors play a pivotal role in the central nervous system (CNS) under both physiological and pathological conditions. The functional diversity of NMDA receptors can be mainly attributed to the...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012799201630
更新日期:2012-02-01 00:00:00
abstract::Hypertriglyceridaemia is associated with insulin resistance, hypertension, obesity and diabetes. The management of hypertriglyceridaemia and atherogenic dyslipidaemias increasingly involves the use of several drugs for different aspects of the metabolic syndrome. This review highlights the agents for treatment of bloo...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009787846380
更新日期:2009-04-01 00:00:00
abstract::Pain is a complex multidimensional concept that facilitates the initiation of the signaling cascade in response to any noxious stimuli. Action potential generation in the peripheral nociceptor terminal and its transmission through various types of nociceptors corresponding to mechanical, chemical or thermal stimuli le...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450120666190131114244
更新日期:2019-01-01 00:00:00
abstract::PDZ domains play an essential role in a number of cellular processes by facilitating protein scaffolding and assembly of protein complexes. These domains consist of 80 to 90 amino acids and are found to recognize short C-terminal sequences of target proteins. Protein complex formation between PDZ target molecules can ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Pediatric tumors remain the highest cause of death in developed countries. Research on novel therapeutic strategies with lesser side effects is of utmost importance. In this scenario, the role of Renin-Angiotensin System (RAS) axes, the classical one formed by angiotensinconverting enzyme (ACE), Angiotensin ...
journal_title:Current drug targets
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abstract::Most pathological conditions that result in human diseases are associated with altered gene expression. With the advent of new technologies that might control gene expression and a broader knowledge of transcription factors and pathways, new strategies have emerged that offer promising first results for therapeutical ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006777435326
更新日期:2006-06-01 00:00:00
abstract::Flavonoids are chromene analogues abundantly found in plants. It is always of curiosity to discover natural flavonoid structures, since living things, including human, are routinely exposed to these compounds through many dietaries. Indeed, numerous studies conducted so far on flavonoids to display their diverse biolo...
journal_title:Current drug targets
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doi:10.2174/1389450122666210120144921
更新日期:2021-01-20 00:00:00
abstract::To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of T...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2012-10-01 00:00:00
abstract::Family C of G-protein coupled receptors (GPCRs) from humans is constituted by eight metabotropic glutamate (mGlu(1-8)) receptors, two heterodimeric gamma-aminobutyric acid(B) (GABA(B)) receptors, a calcium-sensing receptor (CaR), three taste (T1R) receptors, a promiscuous L-alpha-amino acid receptor (GPRC6A), and five...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Osteosarcoma is considered the most frequent primary bone malignancy. Lung metastasis is the leading cause of death and the most consistent factor for predicting negative patient outcome in osteosarcoma. Third-generation nitrogen-containing bisphosphonates, such as zoledronic acid, have been shown to reduce ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
abstract::Hepatitis C virus (HCV), a member of the Flaviviridae family, has been recognised to be responsible for both parenterally transmitted and sporadic non-A and non-B hepatitis affecting 1-3% of the world population. HCV is a positive stranded RNA virus encoding a single polyprotein which contains at least ten unique stru...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2002-08-01 00:00:00
abstract::Seventy five percent of hospitalized patients with Crohn's disease suffer from malnutrition. One third of Crohn's disease patients have a body mass index below 20. Sixty percent of Crohn's disease patients have sarcopenia. However some inflammatory bowel disease (IBD) patients are obese or suffer from sarcopenic-obesi...
journal_title:Current drug targets
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更新日期:2014-01-01 00:00:00
abstract::Stroke is one of the major causes of mortality and disability in adults in industrialized countries. Despite numerous preclinical studies and clinical trials in the field of cerebral ischemia, no pharmacological agent has been validated in the treatment of acute ischemic, except thrombolysis. Cerebral ischemia is not ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314070005
更新日期:2013-06-01 00:00:00
abstract::Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threating conditions still lacking a definite therapy and carrying a high mortality and morbidity, especially in children and infants. Albeit respiratory assistance and supportive therapies are crucial for ALI/ARDS, many drugs have been pr...
journal_title:Current drug targets
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更新日期:2012-06-01 00:00:00
abstract::NMDA receptors are a subclass of excitatory, ionotropic L-glutamate neurotransmitter receptors. They are.heteromeric, integral membrane proteins being formed by the assembly of the obligatory NR1 subunit together with modulatory NR2 subunits of which four different types, NR2A-NR2D, have been described. This results i...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2001-09-01 00:00:00