PPARs: a potential target for a disease-modifying strategy in stroke.

abstract：:The emergency of responsive drug delivery systems has contributed to the reduced cytotoxicity, the improved permeability in tissues and extended circulation time of the active drug. Of particular, enzyme-responsive nanoplatforms have attracted a lot due to the specificity and efficiency of an enzyme-catalyzed reaction...

journal_title：Current drug targets

authors： Lou XF,Du YZ,Xu XL

更新日期：2021-01-13 00:00:00

abstract：:Viral myocarditis is a cardiac disease caused by Group B Coxsackie virus of Enterovirus genus in the Picorna viridae family. It causes heart failure in children, young and adults. Ten Percent (10%) of acute heart failure and 12% of sudden deaths in young and adults who are less than 40 years is due to this viral myoca...

journal_title：Current drug targets

authors： Daba TM,Zhao Y,Pan Z

更新日期：2019-01-01 00:00:00

abstract：:Neutrophil-dominated inflammation plays an important role in many airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic fibrosis. In cases of asthma where neutrophil-dominated inflammation is a major contributing factor to the disease, treatment with corticosteroids c...

journal_title：Current drug targets

authors： Saffar AS,Ashdown H,Gounni AS

更新日期：2011-04-01 00:00:00

abstract：:The incidence of lung cancer in 2007 is estimated to be 213,380 with 160,390 deaths in the United States. It will contribute to 31% of male and 26% of female cancer-related deaths and is the largest cause of cancer-related mortality in both men and women. Despite some advances in the treatment of advanced non-small ce...

journal_title：Current drug targets

authors： Chen M,Shao W,He J,Wang D

更新日期：2010-01-01 00:00:00

abstract：:Phenothiazines and structurally related compounds alongside their other biological activities are able to modulate multidrug resistance (MDR) in tumor cells. The extensive investigations on their MDR modulation effects consist part of the efforts to overcome MDR - the major obstacle in cancer chemotherapy. In this art...

journal_title：Current drug targets

authors： Tsakovska I,Pajeva I

更新日期：2006-09-01 00:00:00

abstract：:Thromboembolic diseases such as deep vein thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI) and ischemic strokes are mainly responsible for people's morbidity and mortality and have severely affected the people's quality of life all over the world. According to WHO statistics, an average of 17 mill...

journal_title：Current drug targets

authors： Guo L,Ma S

更新日期：2015-01-01 00:00:00

abstract：:It is well known that calorie restriction (CR) can retard the aging process in organisms ranging from yeast to non-human primates, and delay the onset of numerous age-related diseases including neurodegenerative disorders. Translation of the knowledge gained from CR research in animal models to disease prevention stra...

journal_title：Current drug targets

authors： Duan W,Ross CA

更新日期：2010-10-01 00:00:00

abstract：:The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. Of considerable interest, recent evidence indicates that there is a significant cross-talk betw...

journal_title：Current drug targets

authors： Mo YY,Tang H,Miele L

更新日期：2013-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is a multifactorial disorder, with several different factors being suggested to play a synergistic pathophysiological role, inc...

journal_title：Current drug targets

authors： Tamtaji OR,Hadinezhad T,Fallah M,Shahmirzadi AR,Taghizadeh M,Behnam M,Asemi Z

更新日期：2020-01-01 00:00:00

abstract：:The hedgehog signal transduction network is a critical regulator of metazoan development. Inappropriate activation of this network is implicated in several different cancers, including breast. Genetic evidence in mice as well as molecular biological studies in human cells clearly indicate that activated signaling can ...

journal_title：Current drug targets

authors： Visbal AP,Lewis MT

更新日期：2010-09-01 00:00:00

abstract：AIMS:The aim of this study is to provide an overview of several emerging anti-diabetic molecules. BACKGROUND:Diabetes is a complex metabolic disorder involving the dysregulation of glucose homeostasis at various levels. Insulin, which is produced by β-pancreatic cells, is a chief regulator of glucose metabolism, regul...

journal_title：Current drug targets

authors： Wu P,Liu Z,Jiang X,Fang H

更新日期：2020-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common cancers worldwide. In developed countries, its mortality remains high, yet the prevalence has established owing to effective screening programs; however due to the westernization of lifestyle, the incidences in many other countries have increased. Although the treatmen...

journal_title：Current drug targets

authors： Bartoszek A,Fichna J,Tarasiuk A,Binienda A,Fabisiak A,Krajewska JB,Mosińska P,Niewinna K,Salaga M

更新日期：2020-01-01 00:00:00

abstract：:Rituximab has demonstrated a major effect in B-cell lymphoma and in a wide range of autoimmune disorders. Unfortunately, the blood-brain-barrier excludes the disorders restricted to the central nervous system (CNS) from the action of rituximab. The progressive phase of multiple sclerosis (MS) is a prototypical CNS aut...

journal_title：Current drug targets

authors： Bonnan M,Ferrari S,Bertandeau E,Demasles S,Krim E,Miquel M,Barroso B

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Osteosarcoma is considered the most frequent primary bone malignancy. Lung metastasis is the leading cause of death and the most consistent factor for predicting negative patient outcome in osteosarcoma. Third-generation nitrogen-containing bisphosphonates, such as zoledronic acid, have been shown to reduce ...

journal_title：Current drug targets

authors： Ouyang Z,Li H,Zhai Z,Xu J,Dass CR,Qin A,Dai K

更新日期：2018-01-01 00:00:00

abstract：:Recently, the presence of functional interaction between the opioid and cannabinoid system has been shown in various pharmacological responses. Although there is an increasing interest for the feasible therapeutic application of a co-administration of cannabinoids and opioids in some disorders (i.e. to manage pain, to...

journal_title：Current drug targets

authors： Parolaro D,Rubino T,Viganò D,Massi P,Guidali C,Realini N

更新日期：2010-04-01 00:00:00

abstract：:Inflammation is the most common pathology in many orthopedic diseases, such as: rheumatoid arthritis (RA), osteoarthritis (OA) and other reasons caused osteolysis. The leading factor of inflammation was considered as the differentiation of monocyte and the polarization of macrophage. However, cytokines and different c...

journal_title：Current drug targets

authors： Liu Y,Cao Y,Smith W,He B,Yan L

更新日期：2020-01-01 00:00:00

abstract：:The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role in the generation of pacemaker activity of cardiac sinoatrial node cells and immature cardiomyocytes. HCN channels are also present in adult atrial and ventricular cardiomyocytes, where the physiological role is currently und...

journal_title：Current drug targets

authors： Sartiani L,Romanelli MN,Mugelli A,Cerbai E

更新日期：2015-01-01 00:00:00

abstract：:Galectin-1 (Gal1) was the first identified member of the galectin family of beta-galactosidase-binding proteins. Gal1 has important roles in processes fundamental to growth and survival of an organism, including cell adhesion, cell proliferation and apoptosis, and is expressed in many tissues, including the nervous sy...

journal_title：Current drug targets

authors： Gaudet AD,Steeves JD,Tetzlaff W,Ramer MS

更新日期：2005-06-01 00:00:00

abstract：:As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They produced a penicillinase that could hydrolyze the amide bond in the β-lactam ring. Later, an enzyme mediated by an R-...

journal_title：Current drug targets

authors： Frère JM,Sauvage E,Kerff F

更新日期：2016-01-01 00:00:00

abstract：:Osteoporosis causes bone loss, and makes bone to susceptible to fracture. The main cause of osteoporosis is estrogen deficiency. Estrogen, calcitonin, calcium, vitamin D and antioxidants can be used to prevent osteoporosis. For the treatment of osteoporosis, the potential biological activities of traditional medicines...

journal_title：Current drug targets

authors： Süntar I,Akkol EK

更新日期：2013-12-01 00:00:00

abstract：:Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insi...

journal_title：Current drug targets

authors： Mohamed RMP,Kumar J,Yap E,Mohamed IN,Sidi H,Adam RL,Das S

更新日期：2019-01-01 00:00:00

abstract：:It is well documented that elevated levels of PAI-1 in plasma can decrease the fibrinolytic activity in blood with an associated increased risk of thrombus formation. A diverse range of molecules including bacterial lipopolysaccharide (LPS), the inflammatory mediators tumor necrosis factor alpha (TNFalpha) and interle...

journal_title：Current drug targets

authors： Balsara RD,Xu Z,Ploplis VA

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:The mitochondria may very well determine the final commitment of the cell to death, particularly in times of energy stress. Cancer chemotherapeutics such as the anthracycline doxorubicin perturb mitochondrial structure and function in tumour cells, as evidenced in osteosarcoma, for which doxorubicin is used ...

journal_title：Current drug targets

authors： Armstrong J,Dass CR

更新日期：2018-01-01 00:00:00

abstract：:Histone deacetylases are a class of enzymes that play important roles in post translational modifications of histones by deacetylating the lysine residues as well as interacting with various non-histone proteins. This type of enzymes is closely related to oncogenesis and has been proved to be attractive targets for de...

journal_title：Current drug targets

authors： Li X,Zhang J,Xie Y,Jiang Y,Yingjie Z,Xu W

更新日期：2014-06-01 00:00:00

abstract：:Ceruloplasmin contains 95% of the copper in human serum and plays an important role in iron efflux from mammalian cells, including brain cells, due to the activity of ferroxidase, which oxidizes ferrous iron following its transfer to the cell surface via the iron transporter, ferroportin, and delivers ferric iron to e...

journal_title：Current drug targets

authors： Kono S

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:It becomes increasingly evident that the SARS-CoV-2 infection is not limited to the respiratory system. In addition to being a target of the virus, the kidney also seems to have a substantial influence on the outcomes of the disease. METHODS:Data was obtained by a comprehensive and non-systematic search in ...

journal_title：Current drug targets

authors： Bitencourt L,Pedrosa AL,de Brito SBCS,Fróes ACF,de Carvalho ST,Fonseca GG,Ferreira GC,Fradico PF,Simões E Silva AC

更新日期：2021-01-01 00:00:00

abstract：:In the context of OA disease, NF-kappaB transcription factors can be triggered by a host of stress-related stimuli including pro-inflammatory cytokines, excessive mechanical stress and ECM degradation products. Activated NF-kappaB regulates the expression of many cytokines and chemokines, adhesion molecules, inflammat...

journal_title：Current drug targets

authors： Marcu KB,Otero M,Olivotto E,Borzi RM,Goldring MB

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a debilitating disease characterized by bone micro-architecture degradation contributing to fragility fractures. Currently, determining bone mineral density (BMD) via dual-energy X-ray absorptiometry (DXA) is the most reliable form of diagnosing osteoporosis and managing pharmacological treat...

journal_title：Current drug targets

authors： Kwon S,Wang AH,Sadowski CA,Yuksel N,Doschak MR

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To investigated the use of mixed treatment comparison (MTC) meta-analysis models to summarize results from randomized clinical trials (RCTs) on approved pharmacological treatments for neovascular age-related macular degeneration (AMD). METHODS:The number of patients with visual loss or visual gain of 3 or mo...

journal_title：Current drug targets

authors： Virgili G,Novielli N,Menchini F,Murro V,Giacomelli G

更新日期：2011-02-01 00:00:00

abstract：:Acute myeloid leukemia (AML) was the first malignancy for which immunotherapy, in the form of allogeneic hematopoietic stem cell transplantation (allo-HSCT), was integrated into the standard of care. Allo-HSCT however is an imperfect therapy associated with significant morbidity and mortality while offering only incom...

journal_title：Current drug targets

authors： Goswami M,Hourigan CS

更新日期：2017-01-01 00:00:00