Abstract:
:As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They produced a penicillinase that could hydrolyze the amide bond in the β-lactam ring. Later, an enzyme mediated by an R-factor was isolated from Enterobacteriaceae. Methicillin and cephalosporins, both very poor substrates of the S. aureus enzyme, were found to be sensitive to this new enzyme. Third generation cephalosporins appeared to solve the problem, but further enzymes were selected that exhibited extended spectra and could for instance hydrolyze cefotaxime and/or ceftazidime. The discovery of carbapenems constituted a major advance for our antimicrobial arsenal: they inactivated most of the essential penicillin binding proteins effectively and escaped the activity of nearly all known -β lactamases. However, the metallo-β-lactamases, which had not been recognised as a major danger before 1990, were found to act as effective carbapenemases and started to spread in a worrying way. Moreover, carbapenem-hydrolyzing enzymes were found in each of the 3 classes of active-site serine β-lactamases.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Frère JM,Sauvage E,Kerff Fdoi
10.2174/1389450116666151001112859subject
Has Abstractpub_date
2016-01-01 00:00:00pages
974-82issue
9eissn
1389-4501issn
1873-5592pii
CDT-EPUB-70786journal_volume
17pub_type
历史文章,杂志文章,评审abstract::At one time, atherosclerosis was thought to be a simple lipid storage disease. However, it is now recognized as a chronic and progressive inflammation of the arterial wall. Gene deletion experiments in murine models of atherosclerosis that reduce the inflammatory process also reduce disease severity. Identifying the i...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007783220605
更新日期:2007-12-01 00:00:00
abstract::The prevalence of periodontitis is around 20-50% of global population. If not treated, it can cause of tooth loss. Periodontal treatment aims at preserving the patient's teeth from various methods, including infection control and restoring lost periodontal tissue. The periodontium has great biological regenerative pot...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121999201105152639
更新日期:2020-11-05 00:00:00
abstract:BACKGROUND:Intracranial hemorrhage is characterized by the blood vessel rupture and subsequent hematoma expansion. It is the least treatable stroke subtype, resulting in higher morbidity and mortality per incidence than ischemic stroke. Recent studies have observed lower than normal levels of plasma fibrinogen in patie...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666151209123857
更新日期:2017-01-01 00:00:00
abstract::Seventy five percent of hospitalized patients with Crohn's disease suffer from malnutrition. One third of Crohn's disease patients have a body mass index below 20. Sixty percent of Crohn's disease patients have sarcopenia. However some inflammatory bowel disease (IBD) patients are obese or suffer from sarcopenic-obesi...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450115666140930150047
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Preeclampsia, a gestational disease characterized by hypertension and proteinuria twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic pathways remain lar...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450118666170404160000
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Adipose tissue plays a role in the storage of excess energy as triglycerides (TGs). Excess fat accumulation causes various metabolic and cardiovascular diseases. It has been reported that ectopic fat deposition and excess TG accumulation in non-adipose tissue might be important predictors of cardiometabolic ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666180115164103
更新日期:2018-01-01 00:00:00
abstract::Hepatitis C virus (HCV), a member of the Flaviviridae family, has been recognised to be responsible for both parenterally transmitted and sporadic non-A and non-B hepatitis affecting 1-3% of the world population. HCV is a positive stranded RNA virus encoding a single polyprotein which contains at least ten unique stru...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450023347650
更新日期:2002-08-01 00:00:00
abstract::Natural products represent a rich resource for drug delivery and are currently being exploited to target tumour angiogenesis. A vast array of products of natural origin have been shown to have anti-angiogenic potential in preclinical models, including purified endogenous inhibitors, and exogenous compounds derived fro...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006776054951
更新日期:2006-03-01 00:00:00
abstract::It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of osteoarthritis. This might be related to continuous mechanical wear and tear and/or result from time/age-related modifications of cartilage matrix components. Also a mere loss of viable cells over ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007779940070
更新日期:2007-02-01 00:00:00
abstract::Recently, the skin has emerged as a potential alternative route for non-invasive delivery of vaccine. It has been recognized as a highly immune-reactive tissue containing an abundance of antigen presenting cells, especially within the epidermis. Transcutaneous immunization, introduction of antigen through topical appl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011794751492
更新日期:2011-04-01 00:00:00
abstract::Methionine aminopeptidases (MetAP) are intracellular metalloproteins responsible for the removal of the initiator NH(2)-terminal methionine from newly synthesized proteins, thereby facilitating their intracellular translocation from the ribosome. Two types of MetAP enzymes, MetAP-1 (type-I) and MetAP-2 (type-II), whic...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111009011439
更新日期:2010-11-01 00:00:00
abstract::Hepatic diseases are turning into one of the few diseases that cannot be effectively cured due to some reasons although various receptors existed in the liver. Currently, several passive targeting delivery systems have been used in the drug/gene delivery for the treatment of hepatic diseases. For example, Zinostatin s...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666140309232100
更新日期:2014-06-01 00:00:00
abstract::Alzheimer's, a degenerative cause of the brain cells, is called as a progressive neurodegenerative disease and appears to have a heterogeneous etiology with main emphasis on amyloid-cascade and hyperphosphorylated tau-cascade hypotheses, that are directly linked with macromolecules called enzymes such as β- & γ-secret...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666180820104723
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:It becomes increasingly evident that the SARS-CoV-2 infection is not limited to the respiratory system. In addition to being a target of the virus, the kidney also seems to have a substantial influence on the outcomes of the disease. METHODS:Data was obtained by a comprehensive and non-systematic search in ...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121999201013151300
更新日期:2021-01-01 00:00:00
abstract::Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, atherosclerosis, etc. Advancements in molecular research have facilitated investigation of their pathogenesis that is involved in infl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450118666170414113926
更新日期:2017-01-01 00:00:00
abstract::The α7-nAChR plays critical roles in numerous organs and cells by regulating highly organ and cell typespecific functions. In this special issue different Authors have contributed to clarify the different roles played by the α7- nAChR. Post-translational processes such as receptor "underactivation" or "overactivation"...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/138945012800398946
更新日期:2012-05-01 00:00:00
abstract::Recent developments in computer power and chemoinformatics methodology make possible that a huge amount of data become available through internet. These databases are devoted to a wide spectrum of scientific fields. Here we are concerned with databases related to protein-drug interactions. More specifically, databases...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008786949379
更新日期:2008-12-01 00:00:00
abstract::Antiphospholipid syndrome (APS) is characterized by a combination of clinical features consisted of thrombotic or pregnancy-related events and autoimmune antiphospholipid antibodies. In the 1998 International Consensus Preliminary Criteria, APS is defined by the concomitant presence of these clinical features and labo...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450054545999
更新日期:2005-08-01 00:00:00
abstract::Epithelia are the layers of cells that form barriers between external milieu and underlying tissues and thus, are important components of most organs of the body. Epithelial layers of organs, such as the lung, are exposed to various challenges resulting in frequent injury. Epithelial wound healing represents an import...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006776818719
更新日期:2006-05-01 00:00:00
abstract::Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a natural protein expressed in a wide range of tissues in our body. It is a promising anti-cancer agent due to its selective killing of cancer cells, rendering normal cells unharmed. However, resistance occurs either intrinsically or develops ove...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666200302124426
更新日期:2020-01-01 00:00:00
abstract::In this review we focus on the impact of genetic admixture on pharmacogenomics in the American continent, where five centuries of intermarriage between Amerindians, European and Africans, resulted in the extensive population heterogeneity observed nowadays. We compare two alternative views of human genomic variation, ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006779025392
更新日期:2006-12-01 00:00:00
abstract::Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is a multifactorial disorder, with several different factors being suggested to play a synergistic pathophysiological role, inc...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450120666191112155654
更新日期:2020-01-01 00:00:00
abstract::The pivotal role of 5-HT in the control of appetite was formally proposed nearly 30 years ago. In particular endogenous hypothalamic 5-HT has been implicated in the processes of within meal satiation and the end state of post meal satiety. Of the numerous 5-HT receptor subtypes currently identified, 5-HT(1B) and 5-HT(...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450053174550
更新日期:2005-03-01 00:00:00
abstract::The popular use of antioxidative vitamins illustrates the growing awareness of oxidative stress as an important hazard to our health and as an important factor in the ageing process. Superoxide radicals and superoxide-derived reactive oxygen species (ROS) are constantly formed in most cells and tissues. To ensure that...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450110607011505
更新日期:2006-11-01 00:00:00
abstract::The adenosine pathway is a powerful evolutionarily selected mechanism aimed at a fine modulation of inflammatory responses and protection of tissues from injuries. Adenosine exerts its modulatory effects via interaction with G protein-coupled receptors, designated as A(1), A(2A), A(2B) and A(3). In this regard, extrac...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012800564095
更新日期:2012-06-01 00:00:00
abstract::Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids, DAG and phosphatidic acid (PA), by phosphorylating (consuming) DAG to yield PA. Ten mammalian DGK isozymes have been identified to date. In addition to two or three cysteine-rich C1 domains (protein kinase C-like zinc finger stru...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008785132394
更新日期:2008-08-01 00:00:00
abstract::Using a portable infusion pump, intravenous opioid patient-controlled analgesia (PCA) permits a patient to self-deliver a small bolus of opioid to achieve prompt relief without over sedation. Use of PCA for pain management is increasing in hospitals, largely because it can provide equivalent or better analgesia than c...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945005774574524
更新日期:2005-11-01 00:00:00
abstract::Multifunctional rational drug design of protein tyrosine kinases inhibitors allows a potent drug to be utilized to treat more than one disease for greater patient benefits. Many protein tyrosine kinases (PTK), including Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), have been identified as potential drug ta...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006776054997
更新日期:2006-03-01 00:00:00
abstract::Adipose tissue plays an active role in energy balance because it is not only a lipid storing and mobilizing tissue but consists of functionally specialized tissues able to produce heat (in brown adipose tissue) and to produce or release a vast number of so called adipokines or adipocytokines. These consist of polypept...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043490523
更新日期:2004-04-01 00:00:00
abstract::Biomedical science is currently undergoing an epoch-marking transition from its classical phase to the post-genome era. The outstanding success of world-wide genome sequencing efforts, evidenced by the recent publication of the draft of the human genome, together with the completion of several genomes of eukaryotic mo...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450023347452
更新日期:2002-10-01 00:00:00