Curcumin Sensitizes Cancers Towards TRAIL-induced Apoptosis via Extrinsic and Intrinsic Apoptotic Pathways.

abstract：:Nature provides science and society with a virtually unlimited supply of structurally diverse and biologically active molecules; the natural products. While some are directly useful in commercial applications, others are valuable for studying and understanding biological phenomena at the molecular level. An example is...

journal_title：Current drug targets

authors： Nilsson J,Sterner O

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Intracranial hemorrhage is characterized by the blood vessel rupture and subsequent hematoma expansion. It is the least treatable stroke subtype, resulting in higher morbidity and mortality per incidence than ischemic stroke. Recent studies have observed lower than normal levels of plasma fibrinogen in patie...

journal_title：Current drug targets

authors： McBride D,Tang J,Zhang JH

更新日期：2017-01-01 00:00:00

abstract：:Overexpression of the human epidermal growth factor receptor 2 (HER2) is identified in approximately 25- 30% of breast cancers and indicates a poor prognosis. Trastuzumab, the anti-HER2 monoclonal antibody (mAb), has shown significant clinical effects selectively in HER2-overexpressing metastatic breast cancer (MBC) w...

journal_title：Current drug targets

authors： Huang Y,Fu P,Fan W

更新日期：2013-07-01 00:00:00

abstract：:Hepatic diseases are turning into one of the few diseases that cannot be effectively cured due to some reasons although various receptors existed in the liver. Currently, several passive targeting delivery systems have been used in the drug/gene delivery for the treatment of hepatic diseases. For example, Zinostatin s...

journal_title：Current drug targets

authors： Wang Y,Du H,Zhai G

更新日期：2014-06-01 00:00:00

abstract：:The present article aims to review the literature on the relationship between psychology and inflammatory bowel disease (IBD). In particular, the first section is dedicated to explore the role of psychological factors in the etiopathology of the disease, its development and the efficacy of treatments, while the second...

journal_title：Current drug targets

authors： Leone D,Menichetti J,Fiorino G,Vegni E

更新日期：2014-01-01 00:00:00

abstract：:Multi-target drugs against particular multiple targets get better protection, resistance profiles and curative influence by cooperative rules of a key beneficial target with resistance behavior and compensatory elements. Computational techniques can assist us in the efforts to design novel drugs (ligands) with a prefe...

journal_title：Current drug targets

authors： Abdolmaleki A,Ghasemi JB,Ghasemi F

更新日期：2017-01-01 00:00:00

abstract：:Neutrophil-dominated inflammation plays an important role in many airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic fibrosis. In cases of asthma where neutrophil-dominated inflammation is a major contributing factor to the disease, treatment with corticosteroids c...

journal_title：Current drug targets

authors： Saffar AS,Ashdown H,Gounni AS

更新日期：2011-04-01 00:00:00

abstract：:Medicinal plants and mushrooms have alwaysfascinated the world as an attractive source of natural compounds for cancer therapy. From ancient times, they have been valued as gourmet food and folk medicine in Oriental practice. For over 40 years, world has witnessed the overwhelming interest of western scientific frater...

journal_title：Current drug targets

authors： Varghese R,Dalvi YB

更新日期：2020-12-30 00:00:00

abstract：:Nowadays, natural compounds of plant origin with anticancer effects have gained more attention because of their clinical safety and broad efficacy profiles. Autophagy is a multistep lysosomal degradation pathway that may have a unique potential for clinical benefit in the setting of cancer treatment. To retrieve artic...

journal_title：Current drug targets

authors： Forouzanfar F,Mousavi SH

更新日期：2020-01-01 00:00:00

abstract：:Hepatitis C virus (HCV), a member of the Flaviviridae family, has been recognised to be responsible for both parenterally transmitted and sporadic non-A and non-B hepatitis affecting 1-3% of the world population. HCV is a positive stranded RNA virus encoding a single polyprotein which contains at least ten unique stru...

journal_title：Current drug targets

authors： Lahm A,Yagnik A,Tramontano A,Koch U

更新日期：2002-08-01 00:00:00

abstract：:Long term treatment with antiepileptic drugs (AEDs) is the standard therapeutic approach to eradicate seizures. However, a small but significant number of patients fail AED treatment. Intrinsic drug resistance may depend on two main and not necessarily mutually exclusive mechanisms: 1) Loss of pharmacological target (...

journal_title：Current drug targets

authors： Marroni M,Marchi N,Cucullo L,Abbott NJ,Signorelli K,Janigro D

更新日期：2003-05-01 00:00:00

abstract：:A group of oxytocinergic neurons originating in the paraventricular nucleus of the hypothalamus and projecting to extrahypothalamic brain areas (e.g. hippocampus, medulla oblongata and spinal cord) control penile erection. Activation of these neurons by dopamine and dopamine agonists, excitatory amino acids (N-methyl-...

journal_title：Current drug targets

authors： Melis MR,Argiolas A

更新日期：2003-01-01 00:00:00

abstract：:Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by chronic inflammation affecting the colonic mucosa, that can extend to the whole large bowel. The severity of mucosal lesions directly reflects the disease activity and severity and may be prognostic for an aggressive behavior of the pathol...

journal_title：Current drug targets

authors： Fiorino G,Cesarini M,Indriolo A,Malesci A

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Nanotechnology deals with the manufacturing of materials at the atomic and molecular scale. According to the National Nanotechnology Initiative, nanotechnology denotes those structures which are nearly in 1-100 nm size regime in at least one dimension. OBJECTIVE:Nanotechnology in drug delivery has been evid...

journal_title：Current drug targets

authors： Jain A,Kumari R,Tiwari A,Verma A,Tripathi A,Shrivastava A,Jain SK

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:It becomes increasingly evident that the SARS-CoV-2 infection is not limited to the respiratory system. In addition to being a target of the virus, the kidney also seems to have a substantial influence on the outcomes of the disease. METHODS:Data was obtained by a comprehensive and non-systematic search in ...

journal_title：Current drug targets

authors： Bitencourt L,Pedrosa AL,de Brito SBCS,Fróes ACF,de Carvalho ST,Fonseca GG,Ferreira GC,Fradico PF,Simões E Silva AC

更新日期：2021-01-01 00:00:00

abstract：:Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn's disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process cont...

journal_title：Current drug targets

authors： Tanaka T

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Different clinical studies have given inconsistent results on whether the use of antipsychotics increases the risk of thromboembolism. In this paper, we reviewed all relevant literature to provide suggestions for clinical diagnosis and treatment. METHODS:PubMed, Web of Science, EMBASE, MEDLINE, Cochrane and...

journal_title：Current drug targets

authors： Dai L,Zuo Q,Chen F,Chen L,Shen Y

更新日期：2020-01-01 00:00:00

abstract：:Rituximab has demonstrated a major effect in B-cell lymphoma and in a wide range of autoimmune disorders. Unfortunately, the blood-brain-barrier excludes the disorders restricted to the central nervous system (CNS) from the action of rituximab. The progressive phase of multiple sclerosis (MS) is a prototypical CNS aut...

journal_title：Current drug targets

authors： Bonnan M,Ferrari S,Bertandeau E,Demasles S,Krim E,Miquel M,Barroso B

更新日期：2014-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is a multifactorial disorder, with several different factors being suggested to play a synergistic pathophysiological role, inc...

journal_title：Current drug targets

authors： Tamtaji OR,Hadinezhad T,Fallah M,Shahmirzadi AR,Taghizadeh M,Behnam M,Asemi Z

更新日期：2020-01-01 00:00:00

abstract：:Molecularly targeting signaling pathways that are involved in the pathogenesis of hematopoietic malignancies may lead to more specific and efficacious therapies. Activation of the RAS signal transduction cascade is a common feature in the molecular pathogenesis of hematologic malignancies. A number of novel agents tar...

journal_title：Current drug targets

authors： Morgan MA,Ganser A,Reuter CW

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Gabapentin and pregabalin inhibit Ca(2+) currents via high-voltage-activated channels containing the alpha2delta-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of cl...

journal_title：Current drug targets

authors： Dauri M,Faria S,Gatti A,Celidonio L,Carpenedo R,Sabato AF

更新日期：2009-08-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, most cases are on an advanced and inoperable stage, with limited therapeutic options. Existing therapies have shown to be insufficient and novel strategies are urgently necessary. New advances in understanding the disease a...

journal_title：Current drug targets

authors： Nascimento AV,Bousbaa H,Ferreira D,Sarmento B

更新日期：2015-01-01 00:00:00

abstract：:Terpenoids represent a large and diverse class of naturally occurring compounds found in a variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are similar to human hormones. A diet rich in terpenoids is inversely related with the risk of chronic diseases including cancers. Breast an...

journal_title：Current drug targets

authors： Yang H,Dou QP

更新日期：2010-06-01 00:00:00

abstract：:The fibrinolytic system consists of a balance between rates of plasminogen activation and fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three distinct inhibitors of the fibrinolytic system that differently regulate these two steps are plasminogen activator inhibitor type-1 (PAI-...

journal_title：Current drug targets

authors： Urano T,Suzuki Y,Iwaki T,Sano H,Honkura N,Castellino FJ

更新日期：2019-01-01 00:00:00

abstract：:Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insi...

journal_title：Current drug targets

authors： Mohamed RMP,Kumar J,Yap E,Mohamed IN,Sidi H,Adam RL,Das S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The incidence of inflammatory bowel disease (IBD) continues to rise worldwide and despite the advances on pharmacotherapy, the etiopathogenesis of Crohn's disease (CD) and ulcerative colitis (UC) remains underexplained. In this context, the migratory waves of the last decades created a challenging setting to...

journal_title：Current drug targets

authors： Estevinho MM,Lopes DJM,Souto MT,Magro F

更新日期：2020-11-19 00:00:00

abstract：:The development of novel T cell therapies to target leukemia has facilitated the translation of this approach for hematologic malignancies. Different methods of manufacturing leukemia-specific T cells have evolved, along with additional measures to increase the safety of this therapy. This is an overview of expanded T...

journal_title：Current drug targets

authors： Cruz CR,Bollard CM

更新日期：2017-01-01 00:00:00

abstract：:It is well known that calorie restriction (CR) can retard the aging process in organisms ranging from yeast to non-human primates, and delay the onset of numerous age-related diseases including neurodegenerative disorders. Translation of the knowledge gained from CR research in animal models to disease prevention stra...

journal_title：Current drug targets

authors： Duan W,Ross CA

更新日期：2010-10-01 00:00:00

abstract：:RNA, as an intermediate in the production of every gene encoded protein and the genetic material of many pathogenic viruses, presents an attractive target for both biological and therapeutic manipulation. Despite its extensive involvement in living systems, its chemical diversity based on four units is relatively low ...

journal_title：Current drug targets

authors： Cairns MJ,Saravolac EG,Sun LQ

更新日期：2002-06-01 00:00:00

abstract：:Protein-protein interactions (PPIs) play important roles in a variety of biological processes, and many PPIs have been regarded as biologically compelling targets for drug discovery. Extensive efforts have been made to develop feasible proteinprotein docking approaches to study PPIs in silico. Most of these approaches...

journal_title：Current drug targets

authors： Zhang Q,Feng T,Xu L,Sun H,Pan P,Li Y,Li D,Hou T

更新日期：2016-01-01 00:00:00