Abstract:
:Terpenoids represent a large and diverse class of naturally occurring compounds found in a variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are similar to human hormones. A diet rich in terpenoids is inversely related with the risk of chronic diseases including cancers. Breast and prostate cancers are hormone-related diseases and the second leading cause of female and male cancer mortality. Diterpenoid paclitaxel, and its semi-synthetic analogue docetaxel, have entered clinical use against established breast and prostate cancers. Here we reviewed potential molecular targets and biological properties of natural terpenoids, including monoterpenoids, diterpenoids, triterpenoids and tetraterpenoids, and their applications in treatment of human breast and prostate cancers. These terpenoids are able to inhibit tumor cell proliferation and induce tumor cell death by inhibiting multiple cancer-specific targets including the proteasome, NF-kappaB, and antiapoptotic protein Bcl-2. The efficacy of these terpenoids against breast or prostate cancer cells, as demonstrated in pre-clinical studies support clinical application of these naturally occurring terpenoids in treatment of hormone-related human cancers.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Yang H,Dou QPdoi
10.2174/138945010791170842subject
Has Abstractpub_date
2010-06-01 00:00:00pages
733-44issue
6eissn
1389-4501issn
1873-5592pii
BSP/CDT/E-Pub/00071journal_volume
11pub_type
杂志文章,评审abstract:BACKGROUND:Preeclampsia, a gestational disease characterized by hypertension and proteinuria twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic pathways remain lar...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450118666170404160000
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To investigated the use of mixed treatment comparison (MTC) meta-analysis models to summarize results from randomized clinical trials (RCTs) on approved pharmacological treatments for neovascular age-related macular degeneration (AMD). METHODS:The number of patients with visual loss or visual gain of 3 or mo...
journal_title:Current drug targets
pub_type: 杂志文章,meta分析,评审
doi:10.2174/138945011794182665
更新日期:2011-02-01 00:00:00
abstract::The development of novel T cell therapies to target leukemia has facilitated the translation of this approach for hematologic malignancies. Different methods of manufacturing leukemia-specific T cells have evolved, along with additional measures to increase the safety of this therapy. This is an overview of expanded T...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160209143529
更新日期:2017-01-01 00:00:00
abstract::Saponins are plant glycosides that consist of a steroid, steroid alkaloid or triterpenoid aglycone and one or more sugar chains that are covalently linked by glycosidic binding to the aglycone. Glucose, galactose, glucuronic acid, xylose and rhamnose are commonly bound monosaccharides. Saponins are found in all organs...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945009787354584
更新日期:2009-02-01 00:00:00
abstract::Molecularly targeting signaling pathways that are involved in the pathogenesis of hematopoietic malignancies may lead to more specific and efficacious therapies. Activation of the RAS signal transduction cascade is a common feature in the molecular pathogenesis of hematologic malignancies. A number of novel agents tar...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007779940043
更新日期:2007-02-01 00:00:00
abstract::Efforts to interfere with the initiation and promotion of breast and other cancers by endocrine manipulation are not new. It is of obvious benefit to cancer patients to administer substances that combine minimal general toxicity with maximal oestrogen inhibition. Raloxifene is a relatively recent addition to a group o...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450013348263
更新日期:2001-12-01 00:00:00
abstract::The sphingomyelin (SM) pathway is an ubiquitous and evolutionarily conserved signaling system in which ceramide (CA), generated from SM by the action of various isoforms of sphingomyelinases (SMases) functions as an important second messenger. Recent evidence suggests that branching pathways of sphingolipid metabolism...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450003349272
更新日期:2000-09-01 00:00:00
abstract::Treatment of chronic myeloid leukemia (CML) with interferon-alpha (IFN-α) was introduced in the early 1980s. Several clinical trials showed a survival advantage for patients treated with IFN-α compared to conventional chemotherapy. Some patients achieved longstanding complete cytogenetic remissions (i.e. >2 log tumor ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011794815301
更新日期:2011-03-01 00:00:00
abstract::To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of T...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012803530260
更新日期:2012-10-01 00:00:00
abstract::Atherosclerosis is now widely appreciated to represent a chronic inflammatory reaction of the vascular wall in response to dyslipidemia and endothelial distress involving the inflammatory recruitment of leukocytes and the activation of resident vascular cells. The proliferative response of smooth muscle cells critical...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945010791591377
更新日期:2010-08-01 00:00:00
abstract::Infiltrating inflammatory cells into the kidney mediate the initiation and progression of damage by direct cytotoxicity, the secretion of soluble factors such as cytokines and proteases, or by the subsequent induction of further immune response. Before leukocytes can exert their effects on renal damage or repair, they...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006775270213
更新日期:2006-01-01 00:00:00
abstract::Advancing age presents a major challenge for the elderly population in terms of quality of life. The risk of cognitive impairment, motor in-coordination, and behavioral inconsistency due to neuronal damage is relatively higher in aging individuals of society. The brain, through its structural and functional integrity,...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121999201209202247
更新日期:2020-12-09 00:00:00
abstract::Trypanosomes and Leishmaniae are the agents of several important parasitic diseases threatening hundreds of million human beings worldwide. As they diverged early in evolution, they display original molecular characteristics. These peculiarities are each defining putative specific targets for anti-parasitic drugs. Tra...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008786786064
更新日期:2008-11-01 00:00:00
abstract::Thrombomodulin (TM) is a type 1 membrane bound glycoprotein that has a C-type lectin domain at its Nterminus, 6 copies of the epidermal growth factor-like (EGF) motif and serine/threonine rich domain carrying a glycosoaminoglycan external to the membrane. TM binds thrombin changing thrombin's substrate specificity fro...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012799424606
更新日期:2012-03-01 00:00:00
abstract::As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They produced a penicillinase that could hydrolyze the amide bond in the β-lactam ring. Later, an enzyme mediated by an R-...
journal_title:Current drug targets
pub_type: 历史文章,杂志文章,评审
doi:10.2174/1389450116666151001112859
更新日期:2016-01-01 00:00:00
abstract::Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts negative effects on...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450118666170925154428
更新日期:2018-01-01 00:00:00
abstract::Ceruloplasmin contains 95% of the copper in human serum and plays an important role in iron efflux from mammalian cells, including brain cells, due to the activity of ferroxidase, which oxidizes ferrous iron following its transfer to the cell surface via the iron transporter, ferroportin, and delivers ferric iron to e...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012802002320
更新日期:2012-08-01 00:00:00
abstract::Recent developments in computer power and chemoinformatics methodology make possible that a huge amount of data become available through internet. These databases are devoted to a wide spectrum of scientific fields. Here we are concerned with databases related to protein-drug interactions. More specifically, databases...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008786949379
更新日期:2008-12-01 00:00:00
abstract::Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed that Cox-2 is over-expressed in cancer and stroma cells during tumor progression, and anti-cancer chemo-radiotherapies induce expression of Co...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011795677764
更新日期:2011-06-01 00:00:00
abstract::Vaccines have been described as "weapons of mass protection". The eradication of many diseases is testament to their utility and effectiveness. Nevertheless, many vaccine preventable diseases remain prevalent because of political and economic barriers. Additionally, the effects of immaturity and old age, therapies tha...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043490703
更新日期:2004-01-01 00:00:00
abstract::Multidrug resistance (MDR) is a kind of acquired resistance of microorganisms and cancer cells to chemotherapic drugs that are characterized by different chemical structure and different mechanism of action. Classic MDR is the consequence of the over-expression of a variety of proteins that extrude the chemotherapic f...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006777709520
更新日期:2006-07-01 00:00:00
abstract::Withdrawn by the publisher. ...
journal_title:Current drug targets
pub_type: 杂志文章
doi:
更新日期:2015-02-12 00:00:00
abstract::Natural products represent a rich resource for drug delivery and are currently being exploited to target tumour angiogenesis. A vast array of products of natural origin have been shown to have anti-angiogenic potential in preclinical models, including purified endogenous inhibitors, and exogenous compounds derived fro...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945006776054951
更新日期:2006-03-01 00:00:00
abstract::Baculoviruses have adapted novel tactics to transcribe their genes during the late stages of replication. These include a DNA-directed RNA polymerase which is evolutionarily divergent from cellular polymerases. The viral RNA polymerase is a multisubunit and multifunctional RNA polymerase that has the ability to recogn...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007782151324
更新日期:2007-10-01 00:00:00
abstract::Using a portable infusion pump, intravenous opioid patient-controlled analgesia (PCA) permits a patient to self-deliver a small bolus of opioid to achieve prompt relief without over sedation. Use of PCA for pain management is increasing in hospitals, largely because it can provide equivalent or better analgesia than c...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945005774574524
更新日期:2005-11-01 00:00:00
abstract::Long term treatment with antiepileptic drugs (AEDs) is the standard therapeutic approach to eradicate seizures. However, a small but significant number of patients fail AED treatment. Intrinsic drug resistance may depend on two main and not necessarily mutually exclusive mechanisms: 1) Loss of pharmacological target (...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450033491109
更新日期:2003-05-01 00:00:00
abstract::The fibrinolytic system consists of a balance between rates of plasminogen activation and fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three distinct inhibitors of the fibrinolytic system that differently regulate these two steps are plasminogen activator inhibitor type-1 (PAI-...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450120666190715102510
更新日期:2019-01-01 00:00:00
abstract::Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, atherosclerosis, etc. Advancements in molecular research have facilitated investigation of their pathogenesis that is involved in infl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450118666170414113926
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:It becomes increasingly evident that the SARS-CoV-2 infection is not limited to the respiratory system. In addition to being a target of the virus, the kidney also seems to have a substantial influence on the outcomes of the disease. METHODS:Data was obtained by a comprehensive and non-systematic search in ...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121999201013151300
更新日期:2021-01-01 00:00:00
abstract::The number of protein crystal structures being refined to atomic resolution is increasing each year as well as the size of proteins being studied. There are currently 346 structures in the protein data bank which have been refined to or beyond atomic resolution. The benefits of atomic resolution X-ray data are discuss...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450043490613
更新日期:2004-02-01 00:00:00