Adoptive Immunotherapy For Leukemia With Ex vivo Expanded T Cells.

abstract：:In evolutionary terms, mitochondria in apicomplexan parasites appear to be "relicts-in-the-making": they possess the smallest mitochondrial genomes known, encoding only three proteins, and in one genus, Cryptosporidium, the genome is eliminated altogether. Several features of mitochondrial physiology provide validated...

journal_title：Current drug targets

authors： Mather MW,Henry KW,Vaidya AB

更新日期：2007-01-01 00:00:00

abstract：:Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids, DAG and phosphatidic acid (PA), by phosphorylating (consuming) DAG to yield PA. Ten mammalian DGK isozymes have been identified to date. In addition to two or three cysteine-rich C1 domains (protein kinase C-like zinc finger stru...

journal_title：Current drug targets

authors： Sakane F,Imai S,Kai M,Yasuda S,Kanoh H

更新日期：2008-08-01 00:00:00

abstract：:The sialyltransferase family represents a group of enzymes that transfers sialic acid from its common nucleotide sugar donor, CMP-NeuAc, to the terminal carbohydrates group of various glycoproteins and glycolipids. Cloning of these enzymes from mammalian sources indicated these are all type II membrane proteins with t...

journal_title：Current drug targets

authors： Datta AK

更新日期：2009-06-01 00:00:00

abstract：:Over the past years, there was an explosion in the knowledge of the protein target and molecular mechanism associated with various disease types and in the new research of drugs of natural origin. The key idea is to evaluate bioactive natural products interacting with protein domains of different genetic origin but st...

journal_title：Current drug targets

authors： Braca A,Dal Piaz F,Marzocco S,Autore G,Vassallo A,De Tommasi N

更新日期：2011-03-01 00:00:00

abstract：:The popular use of antioxidative vitamins illustrates the growing awareness of oxidative stress as an important hazard to our health and as an important factor in the ageing process. Superoxide radicals and superoxide-derived reactive oxygen species (ROS) are constantly formed in most cells and tissues. To ensure that...

journal_title：Current drug targets

authors： Dröge W,Kinscherf R,Hildebrandt W,Schmitt T

更新日期：2006-11-01 00:00:00

abstract：:The liver is essential for the control of glucose and lipid metabolism. Excessive accumulation of fat in the liver disturbs its function and leads to the development of fatty liver diseases. The nonalcoholic fatty liver disease (NAFLD) is a common type of fatty liver disease found in patients who have not consumed sig...

journal_title：Current drug targets

authors： Chen G

更新日期：2015-01-01 00:00:00

abstract：:The pivotal role of 5-HT in the control of appetite was formally proposed nearly 30 years ago. In particular endogenous hypothalamic 5-HT has been implicated in the processes of within meal satiation and the end state of post meal satiety. Of the numerous 5-HT receptor subtypes currently identified, 5-HT(1B) and 5-HT(...

journal_title：Current drug targets

authors： Halford JC,Harrold JA,Lawton CL,Blundell JE

更新日期：2005-03-01 00:00:00

abstract：:Disorders of emotion regulation such as anxiety disorders and depression are common and yet debilitating. Accumulating evidence suggests involvement of serotonin (5-HT) in the regulation of emotion. Mice with targeted deletion of genes encoding mediators of the serotonergic transmission have proven to be a powerful to...

journal_title：Current drug targets

authors： Araragi N,Lesch KP

更新日期：2013-05-01 00:00:00

abstract：:Various herpes- and poxviruses contain DNA sequences encoding proteins with homology to cellular chemokine receptors, which belong to the family of G protein-coupled receptors (GPCRs). Since GPCRs play a crucial role in cellular communication and chemokine receptors play a prominent role in the immune system, the vira...

journal_title：Current drug targets

authors： Smit MJ,Vink C,Verzijl D,Casarosa P,Bruggeman CA,Leurs R

更新日期：2003-07-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is characterized by a combination of clinical features consisted of thrombotic or pregnancy-related events and autoimmune antiphospholipid antibodies. In the 1998 International Consensus Preliminary Criteria, APS is defined by the concomitant presence of these clinical features and labo...

journal_title：Current drug targets

authors： Nishiguchi T,Kobayashi T

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Some kinds of cations and anions are contained in body fluids such as blood, interstitial fluid, gastrointestinal juice, and tears at relatively high concentration. Ionresponsive drug delivery is available to design the unique dosage formulations which provide optimized drug therapy with effective, safe and ...

journal_title：Current drug targets

authors： Yoshida T,Shakushiro K,Sako K

更新日期：2018-02-08 00:00:00

abstract：BACKGROUND:Osteoporosis is a debilitating disease characterized by bone micro-architecture degradation contributing to fragility fractures. Currently, determining bone mineral density (BMD) via dual-energy X-ray absorptiometry (DXA) is the most reliable form of diagnosing osteoporosis and managing pharmacological treat...

journal_title：Current drug targets

authors： Kwon S,Wang AH,Sadowski CA,Yuksel N,Doschak MR

更新日期：2018-01-01 00:00:00

abstract：:The incidence of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis) is highest during the peak reproductive years, hence the increased concern with the safety of IBD drugs during pregnancy. Over the past 11 years, anti-TNF-alpha antibody therapy has emerged as a treatment approach for refractory IBD...

journal_title：Current drug targets

authors： El Mourabet M,El-Hachem S,Harrison JR,Binion DG

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To investigated the use of mixed treatment comparison (MTC) meta-analysis models to summarize results from randomized clinical trials (RCTs) on approved pharmacological treatments for neovascular age-related macular degeneration (AMD). METHODS:The number of patients with visual loss or visual gain of 3 or mo...

journal_title：Current drug targets

authors： Virgili G,Novielli N,Menchini F,Murro V,Giacomelli G

更新日期：2011-02-01 00:00:00

abstract：:The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this way it regulates e...

journal_title：Current drug targets

authors： Chiozzini C,Toschi E

更新日期：2016-01-01 00:00:00

abstract：:RNA, as an intermediate in the production of every gene encoded protein and the genetic material of many pathogenic viruses, presents an attractive target for both biological and therapeutic manipulation. Despite its extensive involvement in living systems, its chemical diversity based on four units is relatively low ...

journal_title：Current drug targets

authors： Cairns MJ,Saravolac EG,Sun LQ

更新日期：2002-06-01 00:00:00

abstract：:Baculoviruses have adapted novel tactics to transcribe their genes during the late stages of replication. These include a DNA-directed RNA polymerase which is evolutionarily divergent from cellular polymerases. The viral RNA polymerase is a multisubunit and multifunctional RNA polymerase that has the ability to recogn...

journal_title：Current drug targets

authors： Passarelli AL,Guarino LA

更新日期：2007-10-01 00:00:00

abstract：:Thrombomodulin (TM) is a type 1 membrane bound glycoprotein that has a C-type lectin domain at its Nterminus, 6 copies of the epidermal growth factor-like (EGF) motif and serine/threonine rich domain carrying a glycosoaminoglycan external to the membrane. TM binds thrombin changing thrombin's substrate specificity fro...

journal_title：Current drug targets

authors： Morser J

更新日期：2012-03-01 00:00:00

abstract：:Escalating resistance to almost every class of antibiotics is reducing the utility of currently available antimicrobial drugs. A part of this menace is attributed to poor pharmacokinetics and pharmacodynamics of the drug. Improvement in drug delivery is the most challenging task encountered by the pharmaceutical indus...

journal_title：Current drug targets

authors： Jamil B,Bokhari H,Imran M

更新日期：2017-01-01 00:00:00

abstract：:Prostaglandins serve as the connecting link between inflammation and cancer. mPGES1, the downstream enzyme in the prostaglandin pathway is considered a better target than COX-2 against the progression of cancer due to the cardiovascular and other complications associated with the inhibition of the latter. Despite the ...

journal_title：Current drug targets

authors： Ramanan M,Doble M

更新日期：2017-01-01 00:00:00

abstract：:Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the first step of proline degradation, during which ROS and/or ATP is generated. POX is widely distributed in living organisms and is responsible for a number of regulatory processes such as redox homeostasis, osmotic adaptation, cell signaling ...

journal_title：Current drug targets

authors： Kononczuk J,Czyzewska U,Moczydlowska J,Surażyński A,Palka J,Miltyk W

更新日期：2015-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is a multifactorial disorder, with several different factors being suggested to play a synergistic pathophysiological role, inc...

journal_title：Current drug targets

authors： Tamtaji OR,Hadinezhad T,Fallah M,Shahmirzadi AR,Taghizadeh M,Behnam M,Asemi Z

更新日期：2020-01-01 00:00:00

abstract：:Recent developments in computer power and chemoinformatics methodology make possible that a huge amount of data become available through internet. These databases are devoted to a wide spectrum of scientific fields. Here we are concerned with databases related to protein-drug interactions. More specifically, databases...

journal_title：Current drug targets

authors： Timmers LF,Pauli I,Caceres RA,de Azevedo WF Jr

更新日期：2008-12-01 00:00:00

abstract：:Breast cancer is the most common cancer in women in the United States, with African-American (AA) women showing significantly higher rates than Caucasian-American (CA) women do. The reason for this racial disparity remains unknown, and factors that might be responsible for the differences in incidence and mortality ha...

journal_title：Current drug targets

authors： Rahman KM,Sakr WA

更新日期：2012-12-01 00:00:00

abstract：:Medical chronobiology deals with the way body's rhythm influences a person's health and disease states. To match body rhythms, deliberate alteration of drug concentration is done to optimize therapeutic outcomes and minimize size effects and this approach is known as Chronotherapeutics. In general the concept of homeo...

journal_title：Current drug targets

authors： Das R,Mehta DK

更新日期：2019-01-01 00:00:00

abstract：:Recently, the skin has emerged as a potential alternative route for non-invasive delivery of vaccine. It has been recognized as a highly immune-reactive tissue containing an abundance of antigen presenting cells, especially within the epidermis. Transcutaneous immunization, introduction of antigen through topical appl...

journal_title：Current drug targets

authors： Gupta PN,Vyas SP

更新日期：2011-04-01 00:00:00

abstract：:Using a portable infusion pump, intravenous opioid patient-controlled analgesia (PCA) permits a patient to self-deliver a small bolus of opioid to achieve prompt relief without over sedation. Use of PCA for pain management is increasing in hospitals, largely because it can provide equivalent or better analgesia than c...

journal_title：Current drug targets

authors： Mann C,Ouro-Bang'na F,Eledjam JJ

更新日期：2005-11-01 00:00:00

abstract：:Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In p...

journal_title：Current drug targets

authors： Turrini E,Ferruzzi L,Fimognari C

更新日期：2017-01-01 00:00:00

abstract：:Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, atherosclerosis, etc. Advancements in molecular research have facilitated investigation of their pathogenesis that is involved in infl...

journal_title：Current drug targets

authors： Rahman M,Beg S,Verma A,Kazmi I,Patel DK,Anwar F,Al Abbasi FA,Kumar V

更新日期：2017-01-01 00:00:00

abstract：:Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor's role in the adapted immunity and inflammation as well as the receptor's ...

journal_title：Current drug targets

authors： Rutkowska A,Dev KK,Sailer AW

更新日期：2016-01-01 00:00:00