Abstract:
:Baculoviruses have adapted novel tactics to transcribe their genes during the late stages of replication. These include a DNA-directed RNA polymerase which is evolutionarily divergent from cellular polymerases. The viral RNA polymerase is a multisubunit and multifunctional RNA polymerase that has the ability to recognize late promoters, transcribe the linked genes, and process the transcripts at both 5' and 3' ends. The viral RNA polymerase binds to late viral gene promoter elements that are compact and differ from early viral gene and cellular promoters. Baculoviruses also encode a number of proteins devoted to the synthesis of late transcripts. Many of these are highly conserved among all the baculovirus genomes sequenced to date, suggesting common transcription mechanisms. Although viral late mRNAs resemble host mRNAs, the transcribing/processing machinery is distinct. Characterization of the late gene transcription apparatus will elucidate new viral mechanisms for transcription.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Passarelli AL,Guarino LAdoi
10.2174/138945007782151324subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1103-15issue
10eissn
1389-4501issn
1873-5592journal_volume
8pub_type
杂志文章,评审abstract::The popular use of antioxidative vitamins illustrates the growing awareness of oxidative stress as an important hazard to our health and as an important factor in the ageing process. Superoxide radicals and superoxide-derived reactive oxygen species (ROS) are constantly formed in most cells and tissues. To ensure that...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450110607011505
更新日期:2006-11-01 00:00:00
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450053765833
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160527142138
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Current drug targets
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更新日期:2004-10-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450054021981
更新日期:2005-06-01 00:00:00
abstract::Radiation-induced myelosuppression remains a rate-limiting factor of radiotherapy and chemotherapy. Therefore, hematological targets of radiation damage are of great significance for radiation oncology and normal tissue injury and protection. Protection of hematopoietic stem and progenitor cells is pivotal. In order t...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111009011375
更新日期:2010-11-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2006-02-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945010792006753
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journal_title:Current drug targets
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更新日期:2003-05-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450120666190402145325
更新日期:2019-01-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1573399811666150615145409
更新日期:2018-01-01 00:00:00
abstract::Withdrawn by the publisher. ...
journal_title:Current drug targets
pub_type: 杂志文章
doi:
更新日期:2015-02-12 00:00:00
abstract::Crohn's disease (CD) and ulcerative colitis (UC), two chronic and relapsing inflammatory bowel diseases (IBD), are supposed to develop in genetically-predisposed individuals as a result of an excessive immune mucosal response directed against normal components of the gut microbiota. There is also evidence that defects...
journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2006-08-01 00:00:00
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journal_title:Current drug targets
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更新日期:2021-01-01 00:00:00
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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更新日期:2014-01-01 00:00:00
abstract::The development of novel T cell therapies to target leukemia has facilitated the translation of this approach for hematologic malignancies. Different methods of manufacturing leukemia-specific T cells have evolved, along with additional measures to increase the safety of this therapy. This is an overview of expanded T...
journal_title:Current drug targets
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abstract::The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this way it regulates e...
journal_title:Current drug targets
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journal_title:Current drug targets
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