Cervical cancer: are there potential new targets? An update on preclinical and clinical results.

abstract：BACKGROUND:Some kinds of cations and anions are contained in body fluids such as blood, interstitial fluid, gastrointestinal juice, and tears at relatively high concentration. Ionresponsive drug delivery is available to design the unique dosage formulations which provide optimized drug therapy with effective, safe and ...

journal_title：Current drug targets

authors： Yoshida T,Shakushiro K,Sako K

更新日期：2018-02-08 00:00:00

abstract：:5-Lipoxygenase (5-LO) is the key enzyme involved in the synthesis of pro-inflammatory leukotrienes (LTs) and has become a prime target for new drug discovery research and development efforts by the pharmaceutical and biotech industry. The pathophysiological effects of LTs can be modulated by the selective inhibition o...

journal_title：Current drug targets

authors： Anwar Y,Sabir JS,Qureshi MI,Saini KS

更新日期：2014-04-01 00:00:00

abstract：:Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the first step of proline degradation, during which ROS and/or ATP is generated. POX is widely distributed in living organisms and is responsible for a number of regulatory processes such as redox homeostasis, osmotic adaptation, cell signaling ...

journal_title：Current drug targets

authors： Kononczuk J,Czyzewska U,Moczydlowska J,Surażyński A,Palka J,Miltyk W

更新日期：2015-01-01 00:00:00

abstract：:The Metabolic Syndrome is a common metabolic disease associated with an increased risk for atherosclerotic cardiovascular disease and mortality. In contrast to "traditional" risk factors for atherosclerosis, such as low-density lipoprotein cholesterol, the Metabolic Syndrome represents a network of interacting risk fa...

journal_title：Current drug targets

authors： Péterfy M,Davis RC,Lusis AJ

更新日期：2007-11-01 00:00:00

abstract：:Osteoporosis causes bone loss, and makes bone to susceptible to fracture. The main cause of osteoporosis is estrogen deficiency. Estrogen, calcitonin, calcium, vitamin D and antioxidants can be used to prevent osteoporosis. For the treatment of osteoporosis, the potential biological activities of traditional medicines...

journal_title：Current drug targets

authors： Süntar I,Akkol EK

更新日期：2013-12-01 00:00:00

abstract：:Fracture healing is a process of recovering injured bone tissue forms and functions. Osteoporosis can delay the healing process, which contributes to personal suffering and loss of activities. Osteoporosis patients tend to lose bone mass at the metaphyseal region which require treatment to increase bone mass. Postmeno...

journal_title：Current drug targets

authors： Ibrahim N',Mohamed N,Shuid AN

更新日期：2013-12-01 00:00:00

abstract：:Novel anti-vasculature strategies that are emerging for the treatment of cancer and for the inhibition of angiogenesis may be a promising new tool for the adjuvant therapy of malignant tumours. Over the last fifteen years, several reports have been published concerning the relationship between tumour progression and a...

journal_title：Current drug targets

authors： Pastorino F,Di Paolo D,Loi M,Becherini P,Caffa I,Zorzoli A,Marimpietri D,Carosio R,Perri P,Montaldo PG,Brignole C,Pagnan G,Ribatti D,Allen TM,Ponzoni M

更新日期：2009-10-01 00:00:00

abstract：:Acute myeloid leukemia (AML) was the first malignancy for which immunotherapy, in the form of allogeneic hematopoietic stem cell transplantation (allo-HSCT), was integrated into the standard of care. Allo-HSCT however is an imperfect therapy associated with significant morbidity and mortality while offering only incom...

journal_title：Current drug targets

authors： Goswami M,Hourigan CS

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Osteosarcoma is considered the most frequent primary bone malignancy. Lung metastasis is the leading cause of death and the most consistent factor for predicting negative patient outcome in osteosarcoma. Third-generation nitrogen-containing bisphosphonates, such as zoledronic acid, have been shown to reduce ...

journal_title：Current drug targets

authors： Ouyang Z,Li H,Zhai Z,Xu J,Dass CR,Qin A,Dai K

更新日期：2018-01-01 00:00:00

abstract：:Nature provides science and society with a virtually unlimited supply of structurally diverse and biologically active molecules; the natural products. While some are directly useful in commercial applications, others are valuable for studying and understanding biological phenomena at the molecular level. An example is...

journal_title：Current drug targets

authors： Nilsson J,Sterner O

更新日期：2011-10-01 00:00:00

abstract：:Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor's role in the adapted immunity and inflammation as well as the receptor's ...

journal_title：Current drug targets

authors： Rutkowska A,Dev KK,Sailer AW

更新日期：2016-01-01 00:00:00

abstract：:Disorders of emotion regulation such as anxiety disorders and depression are common and yet debilitating. Accumulating evidence suggests involvement of serotonin (5-HT) in the regulation of emotion. Mice with targeted deletion of genes encoding mediators of the serotonergic transmission have proven to be a powerful to...

journal_title：Current drug targets

authors： Araragi N,Lesch KP

更新日期：2013-05-01 00:00:00

abstract：:Trypanosomes and Leishmaniae are the agents of several important parasitic diseases threatening hundreds of million human beings worldwide. As they diverged early in evolution, they display original molecular characteristics. These peculiarities are each defining putative specific targets for anti-parasitic drugs. Tra...

journal_title：Current drug targets

authors： Vanhamme L

更新日期：2008-11-01 00:00:00

abstract：:Molecularly targeting signaling pathways that are involved in the pathogenesis of hematopoietic malignancies may lead to more specific and efficacious therapies. Activation of the RAS signal transduction cascade is a common feature in the molecular pathogenesis of hematologic malignancies. A number of novel agents tar...

journal_title：Current drug targets

authors： Morgan MA,Ganser A,Reuter CW

更新日期：2007-02-01 00:00:00

abstract：:Pancreatic cancer is predicted to be the second deadliest malignancy (a median survival of 4-6 months and a 5-year survival of less than 5%) in the USA by 2020. Although current medical detection technologies have dramatically improved the survival rate for patients with other gastrointestinal malignancies, the dismal...

journal_title：Current drug targets

authors： Barton LA,Ren J

更新日期：2018-01-01 00:00:00

abstract：:The genus Zanthoxylum (Rutaceae) comprises about 250 species, of which many are used as food, often as condiments, substituting pepper due to the pungent taste of fruits, seeds, leaves, and bark, and therapeutic remedies especially in Eastern Asian countries and in Central America. The whole plant is also consumed as ...

journal_title：Current drug targets

authors： Epifano F,Curini M,Marcotullio MC,Genovese S

更新日期：2011-12-01 00:00:00

abstract：:Methionine aminopeptidases (MetAP) are intracellular metalloproteins responsible for the removal of the initiator NH(2)-terminal methionine from newly synthesized proteins, thereby facilitating their intracellular translocation from the ribosome. Two types of MetAP enzymes, MetAP-1 (type-I) and MetAP-2 (type-II), whic...

journal_title：Current drug targets

authors： Mauriz JL,Martín-Renedo J,García-Palomo A,Tuñón MJ,González-Gallego J

更新日期：2010-11-01 00:00:00

abstract：:Overexpression of the human epidermal growth factor receptor 2 (HER2) is identified in approximately 25- 30% of breast cancers and indicates a poor prognosis. Trastuzumab, the anti-HER2 monoclonal antibody (mAb), has shown significant clinical effects selectively in HER2-overexpressing metastatic breast cancer (MBC) w...

journal_title：Current drug targets

authors： Huang Y,Fu P,Fan W

更新日期：2013-07-01 00:00:00

abstract：:Target discovery using the molecular approach, as opposed to the more traditional systems approach requires the study of the cellular or biological process underlying a condition or disease. The approaches that are employed by the "bench" scientist may be genetic, genomic or proteomic and each has its rightful place i...

journal_title：Current drug targets

authors： Rylova G,Ozdian T,Varanasi L,Soural M,Hlavac J,Holub D,Dzubak P,Hajduch M

更新日期：2015-01-01 00:00:00

abstract：:Advancing age presents a major challenge for the elderly population in terms of quality of life. The risk of cognitive impairment, motor in-coordination, and behavioral inconsistency due to neuronal damage is relatively higher in aging individuals of society. The brain, through its structural and functional integrity,...

journal_title：Current drug targets

authors： Dhote V,Samundre P,Ganeshpurkar A,Upaganlawar A

更新日期：2020-12-09 00:00:00

abstract：:The growing number of cellular and molecular pathways believed to be involved in mechanisms of ischemic cell death in the brain has spurred a similar growth in the number of potential neuroprotective modalities, the majority of which are pharmacological in nature. Preventing or minimizing the first few steps in the ca...

journal_title：Current drug targets

authors： Schurr A

更新日期：2004-10-01 00:00:00

abstract：:Terpenoids represent a large and diverse class of naturally occurring compounds found in a variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are similar to human hormones. A diet rich in terpenoids is inversely related with the risk of chronic diseases including cancers. Breast an...

journal_title：Current drug targets

authors： Yang H,Dou QP

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Osteoporosis is a debilitating disease characterized by bone micro-architecture degradation contributing to fragility fractures. Currently, determining bone mineral density (BMD) via dual-energy X-ray absorptiometry (DXA) is the most reliable form of diagnosing osteoporosis and managing pharmacological treat...

journal_title：Current drug targets

authors： Kwon S,Wang AH,Sadowski CA,Yuksel N,Doschak MR

更新日期：2018-01-01 00:00:00

abstract：:Type 2 diabetes, which has dramatically increased during the last decade normally results from a combination of pancreatic beta cell dysfunction and insulin resistance. One of the most recent risk factors identified for type 2 diabetes is a sub-optimal fetal and neonatal environment. Numerous human epidemiological stu...

journal_title：Current drug targets

authors： Reusens B,Ozanne SE,Remacle C

更新日期：2007-08-01 00:00:00

abstract：:Protein-protein interactions (PPIs) play important roles in a variety of biological processes, and many PPIs have been regarded as biologically compelling targets for drug discovery. Extensive efforts have been made to develop feasible proteinprotein docking approaches to study PPIs in silico. Most of these approaches...

journal_title：Current drug targets

authors： Zhang Q,Feng T,Xu L,Sun H,Pan P,Li Y,Li D,Hou T

更新日期：2016-01-01 00:00:00

abstract：:The incidence of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis) is highest during the peak reproductive years, hence the increased concern with the safety of IBD drugs during pregnancy. Over the past 11 years, anti-TNF-alpha antibody therapy has emerged as a treatment approach for refractory IBD...

journal_title：Current drug targets

authors： El Mourabet M,El-Hachem S,Harrison JR,Binion DG

更新日期：2010-02-01 00:00:00

abstract：:The complexity of the central nervous system (CNS) exposes it to a number of different diseases, often caused by only small variations in gene sequence or expression level. Antisense oligonucleotides and RNA interference-mediated therapies hold great promise for the treatment of CNS diseases in which neurodegeneration...

journal_title：Current drug targets

authors： Forte A,Cipollaro M,Cascino A,Galderisi U

更新日期：2005-02-01 00:00:00

abstract：:Diabetes is one of the most concerning diseases in modern times. Despite considerable advances in therapeutic management, the prevalence of diabetes and its contribution to death and disability continue to be a major health problem. Diabetic vasculopathies are the leading cause of mortality and morbidity in diabetic p...

journal_title：Current drug targets

authors： de Oliveira AA,Webb RC,Nunes KP

更新日期：2019-01-01 00:00:00

abstract：:The aim of the present article is to review the indications, the monitoring and the complications of sedation in the post-anaesthesia care unit (PACU). In this setting, sedation is often an unwanted side effect of anaesthetic drugs that delay discharge, however it could be specifically indicated. Such indications incl...

journal_title：Current drug targets

authors： De Gaudio AR,Rinaldi S

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Recently, there are scientific attempts to discover new drugs in the biotechnology industry in order to treat various diseases including atherosclerosis. OBJECTIVE:The main objective of the present review was to highlight the cellular, molecular biology and inflammatory process related to the atheromatous p...

journal_title：Current drug targets

authors： Thent ZC,Chakraborty C,Mahakkanukrauh P,Nik Ritza Kosai Nik Mahmood N,Rajan R,Das S

更新日期：2017-01-01 00:00:00