Update on statins: hope for osteoporotic fracture healing treatment.

abstract：:Medical chronobiology deals with the way body's rhythm influences a person's health and disease states. To match body rhythms, deliberate alteration of drug concentration is done to optimize therapeutic outcomes and minimize size effects and this approach is known as Chronotherapeutics. In general the concept of homeo...

journal_title：Current drug targets

authors： Das R,Mehta DK

更新日期：2019-01-01 00:00:00

abstract：:Disorders of emotion regulation such as anxiety disorders and depression are common and yet debilitating. Accumulating evidence suggests involvement of serotonin (5-HT) in the regulation of emotion. Mice with targeted deletion of genes encoding mediators of the serotonergic transmission have proven to be a powerful to...

journal_title：Current drug targets

authors： Araragi N,Lesch KP

更新日期：2013-05-01 00:00:00

abstract：:Stroke is one of the leading causes of death and disability worldwide. Because stroke is a multifactorial disease with a short therapeutic window many clinical stroke trials have failed and the only currently approved therapy is thrombolysis. MicroRNAs (miRNA) are endogenously expressed noncoding short single-stranded...

journal_title：Current drug targets

authors： Ouyang YB,Stary CM,Yang GY,Giffard R

更新日期：2013-01-01 00:00:00

abstract：:The CD6 molecule is a pan T cell marker involved in T cell regulation. Although CD6 expression has been correlated with human autoimmune diseases, only a few therapeutic approaches are exploring this molecule as target in the clinic. The biological functions and mechanisms of actions of CD6 have not been definitively ...

journal_title：Current drug targets

authors： Hernández P,Moreno E,Aira LE,Rodríguez PC

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Lymphatic filariasis is a pervasive and life-threatening disease for human beings. Currently, 893 million people in 49 countries worldwide affected by lymphatic filariasis as per WHO statistics. The concealed aspects of lymphatic diseases such as delayed disease detection, inappropriate disease imaging, the ...

journal_title：Current drug targets

authors： Shrivastava S,Gupta A,Kaur CD

更新日期：2020-01-01 00:00:00

abstract：:Various strategies for the use of zein for controlled drug release have been investigated and reported in the literature, especially engineering strategies for using zein conjugates to enhance oral bioavailability and targeted delivery, which has attracted interest in recent research. Although still limited, the abili...

journal_title：Current drug targets

authors： Tran PH,Tran TT

更新日期：2020-01-01 00:00:00

abstract：:The α7-nAChR plays critical roles in numerous organs and cells by regulating highly organ and cell typespecific functions. In this special issue different Authors have contributed to clarify the different roles played by the α7- nAChR. Post-translational processes such as receptor "underactivation" or "overactivation"...

journal_title：Current drug targets

authors： Russo P,Cardinale A,Shuller H

更新日期：2012-05-01 00:00:00

abstract：:The incidence of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis) is highest during the peak reproductive years, hence the increased concern with the safety of IBD drugs during pregnancy. Over the past 11 years, anti-TNF-alpha antibody therapy has emerged as a treatment approach for refractory IBD...

journal_title：Current drug targets

authors： El Mourabet M,El-Hachem S,Harrison JR,Binion DG

更新日期：2010-02-01 00:00:00

abstract：:Long term treatment with antiepileptic drugs (AEDs) is the standard therapeutic approach to eradicate seizures. However, a small but significant number of patients fail AED treatment. Intrinsic drug resistance may depend on two main and not necessarily mutually exclusive mechanisms: 1) Loss of pharmacological target (...

journal_title：Current drug targets

authors： Marroni M,Marchi N,Cucullo L,Abbott NJ,Signorelli K,Janigro D

更新日期：2003-05-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are the leading cause of death, chronic illness and disability in Western countries. The most common cause of CVD derives from the harmful effects of acute myocardial ischemia and subsequent reperfusion injury. Cardioprotection against acute ischemia/ reperfusion injury is made possible b...

journal_title：Current drug targets

authors： Penna C,Granata R,Tocchetti CG,Gallo MP,Alloatti G,Pagliaro P

更新日期：2015-01-01 00:00:00

abstract：:Protein-protein interactions (PPIs) play important roles in a variety of biological processes, and many PPIs have been regarded as biologically compelling targets for drug discovery. Extensive efforts have been made to develop feasible proteinprotein docking approaches to study PPIs in silico. Most of these approaches...

journal_title：Current drug targets

authors： Zhang Q,Feng T,Xu L,Sun H,Pan P,Li Y,Li D,Hou T

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Global death rate due to cardiovascular diseases (CVDs) is highest as compared to other ailments. Principal risk factor associated with CVDs is hypertension. Major classes of current antihypertensive (AHT) therapies include angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs)...

journal_title：Current drug targets

authors： Niaz T,Hafeez Z,Imran M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Pediatric tumors remain the highest cause of death in developed countries. Research on novel therapeutic strategies with lesser side effects is of utmost importance. In this scenario, the role of Renin-Angiotensin System (RAS) axes, the classical one formed by angiotensinconverting enzyme (ACE), Angiotensin ...

journal_title：Current drug targets

authors： de Paula Gonzaga ALAC,Palmeira VA,Ribeiro TFS,Costa LB,de Sá Rodrigues KE,Simões-E-Silva AC

更新日期：2020-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is a multifactorial disorder, with several different factors being suggested to play a synergistic pathophysiological role, inc...

journal_title：Current drug targets

authors： Tamtaji OR,Hadinezhad T,Fallah M,Shahmirzadi AR,Taghizadeh M,Behnam M,Asemi Z

更新日期：2020-01-01 00:00:00

abstract：:The complexity of the central nervous system (CNS) exposes it to a number of different diseases, often caused by only small variations in gene sequence or expression level. Antisense oligonucleotides and RNA interference-mediated therapies hold great promise for the treatment of CNS diseases in which neurodegeneration...

journal_title：Current drug targets

authors： Forte A,Cipollaro M,Cascino A,Galderisi U

更新日期：2005-02-01 00:00:00

abstract：:Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, atherosclerosis, etc. Advancements in molecular research have facilitated investigation of their pathogenesis that is involved in infl...

journal_title：Current drug targets

authors： Rahman M,Beg S,Verma A,Kazmi I,Patel DK,Anwar F,Al Abbasi FA,Kumar V

更新日期：2017-01-01 00:00:00

abstract：:Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor's role in the adapted immunity and inflammation as well as the receptor's ...

journal_title：Current drug targets

authors： Rutkowska A,Dev KK,Sailer AW

更新日期：2016-01-01 00:00:00

abstract：:Natural products represent a rich resource for drug delivery and are currently being exploited to target tumour angiogenesis. A vast array of products of natural origin have been shown to have anti-angiogenic potential in preclinical models, including purified endogenous inhibitors, and exogenous compounds derived fro...

journal_title：Current drug targets

authors： Neal CP,Berry DP,Doucas H,Manson MM,Steward W,Garcea G

更新日期：2006-03-01 00:00:00

abstract：:While breast cancer (BC) is commonest malignancy among female with highest death rate, male breast cancer (MBC) is very rare but exhibits highest cancer specific death in men and the incidences of MBCs are rising rapidly. Due to rarity of the disease, no detail information about biomarkers and drug targets available a...

journal_title：Current drug targets

authors： Barh D

更新日期：2009-01-01 00:00:00

abstract：:Aldose reductase (AR) enzymatically transforms cytosolic glucose into sorbitol, a molecule that poorly penetrates cell membranes and is sometimes slowly metabolized. Hyperglycemia can cause intracellular accumulation of sorbitol and its metabolite, fructose, which can create osmotic swelling and cell dysfunction. Driv...

journal_title：Current drug targets

authors： Oates PJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Gabapentin and pregabalin inhibit Ca(2+) currents via high-voltage-activated channels containing the alpha2delta-1 subunit, reducing neurotransmitter release and attenuating the postsynaptic excitability. They are antiepileptic drugs successfully used also for the chronic pain treatment. A large number of cl...

journal_title：Current drug targets

authors： Dauri M,Faria S,Gatti A,Celidonio L,Carpenedo R,Sabato AF

更新日期：2009-08-01 00:00:00

abstract：:The most widely used mouse models for atherosclerosis are LDL receptor knockout (KO) mice and apolipoprotein E (apoE) KO mice fed standard chow diets or lipid-supplemented diets. Unfortunately, these do not usually exhibit myocardial infarction or other features of human cardiovascular disease such as occlusive corona...

journal_title：Current drug targets

authors： Braun A,Rigotti A,Trigatti BL

更新日期：2008-03-01 00:00:00

abstract：:Advancing age presents a major challenge for the elderly population in terms of quality of life. The risk of cognitive impairment, motor in-coordination, and behavioral inconsistency due to neuronal damage is relatively higher in aging individuals of society. The brain, through its structural and functional integrity,...

journal_title：Current drug targets

authors： Dhote V,Samundre P,Ganeshpurkar A,Upaganlawar A

更新日期：2020-12-09 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed that Cox-2 is over-expressed in cancer and stroma cells during tumor progression, and anti-cancer chemo-radiotherapies induce expression of Co...

journal_title：Current drug targets

authors： Khan Z,Khan N,Tiwari RP,Sah NK,Prasad GB,Bisen PS

更新日期：2011-06-01 00:00:00

abstract：:Androgen and androgen receptor (AR) play a critical role in the development of prostate cancer. Androgen deprivation therapy (ADT) has become the therapeutic mainstay for patients with metastatic prostate cancer. ADT can reduce the serum testosterone level from the normal range between 500 and 600 ng/dl to the castrat...

journal_title：Current drug targets

authors： Hara N,Nishiyama T

更新日期：2014-01-01 00:00:00

abstract：:Vascular Disrupting Agents (VDA) are a potential new class of oncology drugs that have garnered attention recently as a number of these agents have entered into Phase 2-3 studies. Currently available data suggest how the subsequent evolution of these agents into clinical practice may proceed, with new therapeutic para...

journal_title：Current drug targets

authors： Spear MA,LoRusso P,Mita A,Mita M

更新日期：2011-12-01 00:00:00

abstract：:Inflammatory bowel disease diagnostic and management algorithms continue to rapidly evolve. This is partly driven by advanced radiologic techniques that provide objective, non-invasive evaluations. The realms of information provided by radiology and endoscopy continue to be intertwined. This has led to the question of...

journal_title：Current drug targets

authors： Bruining DH

更新日期：2012-09-01 00:00:00

abstract：:It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of osteoarthritis. This might be related to continuous mechanical wear and tear and/or result from time/age-related modifications of cartilage matrix components. Also a mere loss of viable cells over ...

journal_title：Current drug targets

authors： Aigner T,Haag J,Martin J,Buckwalter J

更新日期：2007-02-01 00:00:00

abstract：:The use of predictive biomarkers provides potential individualized cancer therapeutic options to prevent therapy failure as well as serious toxicities. Several recent studies showed that predictive and prognostic biomarkers are a notable personalized strategy to improve patients' care in several cancers. Trabectedin (...

journal_title：Current drug targets

authors： Souid S,Aissaoui D,Srairi-Abid N,Essafi-Benkhadir K

更新日期：2020-01-01 00:00:00

abstract：:The incidence and mortality of malignant tumors are on the rise, which has become the second leading cause of death in the world. At present, anti-tumor drugs are one of the most common methods for treating cancer. In recent years, with the in-depth study of tumor biology and related disciplines, it has been gradually...

journal_title：Current drug targets

authors： Wang S,Zhou D,Xu Z,Song J,Qian X,Lv X,Luan J

更新日期：2019-01-01 00:00:00