Recent advances in targeted anti-vasculature therapy: the neuroblastoma model.

Abstract:

:Novel anti-vasculature strategies that are emerging for the treatment of cancer and for the inhibition of angiogenesis may be a promising new tool for the adjuvant therapy of malignant tumours. Over the last fifteen years, several reports have been published concerning the relationship between tumour progression and angiogenesis in experimental models of neuroblastoma in vitro and in vivo. Moreover, a high vascular index in neuroblastoma correlates with poor prognosis, suggesting dependence of aggressive tumour growth on active angiogenesis. Here, we present an overview of the most recent advances in anti-vasculature therapy of neuroblastoma, and describe some preclinical results as well as future perspectives.

journal_name

Curr Drug Targets

journal_title

Current drug targets

authors

Pastorino F,Di Paolo D,Loi M,Becherini P,Caffa I,Zorzoli A,Marimpietri D,Carosio R,Perri P,Montaldo PG,Brignole C,Pagnan G,Ribatti D,Allen TM,Ponzoni M

doi

10.2174/138945009789577954

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1021-7

issue

10

eissn

1389-4501

issn

1873-5592

pii

CDT-ms33

journal_volume

10

pub_type

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