Neuroprotection against ischemic/hypoxic brain damage: blockers of ionotropic glutamate receptor and voltage sensitive calcium channels.

Abstract:

:The growing number of cellular and molecular pathways believed to be involved in mechanisms of ischemic cell death in the brain has spurred a similar growth in the number of potential neuroprotective modalities, the majority of which are pharmacological in nature. Preventing or minimizing the first few steps in the cascade of events leading to ischemic cell death would have a more profound effect on the postischemic outcome than intervention at later steps in that cascade. This logic is, of course, at the heart of the urgency in providing the stroke or cardiac arrest patient with the earliest possible neuroprotective treatment. For the purpose of assessing potential neuroprotective modalities, the use of a well-established cerebral hypoxic/ischemic model system is a prerequisite. In our studies, we have used two major approaches, in vitro and in vivo. We evaluated both agonists and antagonists of ionotropic glutamate receptor channels (IGRC) and their effects in exacerbating and attenuating, respectively, the posthypoxic/ischemic outcome. Other drugs were tested for their ability to block the L-type voltage-sensitive calcium channels (VSCC), which are responsible for calcium influx and overload upon hypoxia/ischemia. These two membrane protein entities, the IGRC and the VSCC, are believed to be involved in the early stages of the cellular cascade that leads to the demise of neurons posthypoxia/ischemia. Some of the drugs were also tested for possible interaction with each other searching for possible synergy. These and other published studies in the field are reviewed here.

journal_name

Curr Drug Targets

journal_title

Current drug targets

authors

Schurr A

doi

10.2174/1389450043345209

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

603-18

issue

7

eissn

1389-4501

issn

1873-5592

journal_volume

5

pub_type

杂志文章,评审
  • Ion-Responsive Drug Delivery Systems.

    abstract:BACKGROUND:Some kinds of cations and anions are contained in body fluids such as blood, interstitial fluid, gastrointestinal juice, and tears at relatively high concentration. Ionresponsive drug delivery is available to design the unique dosage formulations which provide optimized drug therapy with effective, safe and ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450117666160527142138

    authors: Yoshida T,Shakushiro K,Sako K

    更新日期:2018-02-08 00:00:00

  • Recent Advances in Protein-Protein Docking.

    abstract::Protein-protein interactions (PPIs) play important roles in a variety of biological processes, and many PPIs have been regarded as biologically compelling targets for drug discovery. Extensive efforts have been made to develop feasible proteinprotein docking approaches to study PPIs in silico. Most of these approaches...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450117666160112112640

    authors: Zhang Q,Feng T,Xu L,Sun H,Pan P,Li Y,Li D,Hou T

    更新日期:2016-01-01 00:00:00

  • Drug-binding databases.

    abstract::Recent developments in computer power and chemoinformatics methodology make possible that a huge amount of data become available through internet. These databases are devoted to a wide spectrum of scientific fields. Here we are concerned with databases related to protein-drug interactions. More specifically, databases...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945008786949379

    authors: Timmers LF,Pauli I,Caceres RA,de Azevedo WF Jr

    更新日期:2008-12-01 00:00:00

  • Sedation in PACU: indications, monitoring, complications.

    abstract::The aim of the present article is to review the indications, the monitoring and the complications of sedation in the post-anaesthesia care unit (PACU). In this setting, sedation is often an unwanted side effect of anaesthetic drugs that delay discharge, however it could be specifically indicated. Such indications incl...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945005774574542

    authors: De Gaudio AR,Rinaldi S

    更新日期:2005-11-01 00:00:00

  • Prospects for atomic resolution and neutron crystallography in drug design.

    abstract::The number of protein crystal structures being refined to atomic resolution is increasing each year as well as the size of proteins being studied. There are currently 346 structures in the protein data bank which have been refined to or beyond atomic resolution. The benefits of atomic resolution X-ray data are discuss...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450043490613

    authors: Coates L,Myles DA

    更新日期:2004-02-01 00:00:00

  • Colloidal carrier systems for transcutaneous immunization.

    abstract::Recently, the skin has emerged as a potential alternative route for non-invasive delivery of vaccine. It has been recognized as a highly immune-reactive tissue containing an abundance of antigen presenting cells, especially within the epidermis. Transcutaneous immunization, introduction of antigen through topical appl...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945011794751492

    authors: Gupta PN,Vyas SP

    更新日期:2011-04-01 00:00:00

  • Role of pemetrexed and platinums combination in patients with non-small cell lung cancer.

    abstract::The incidence of lung cancer in 2007 is estimated to be 213,380 with 160,390 deaths in the United States. It will contribute to 31% of male and 26% of female cancer-related deaths and is the largest cause of cancer-related mortality in both men and women. Despite some advances in the treatment of advanced non-small ce...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945010790031027

    authors: Chen M,Shao W,He J,Wang D

    更新日期:2010-01-01 00:00:00

  • Intrathecal rituximab therapy in multiple sclerosis: review of evidence supporting the need for future trials.

    abstract::Rituximab has demonstrated a major effect in B-cell lymphoma and in a wide range of autoimmune disorders. Unfortunately, the blood-brain-barrier excludes the disorders restricted to the central nervous system (CNS) from the action of rituximab. The progressive phase of multiple sclerosis (MS) is a prototypical CNS aut...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450115666141029234644

    authors: Bonnan M,Ferrari S,Bertandeau E,Demasles S,Krim E,Miquel M,Barroso B

    更新日期:2014-01-01 00:00:00

  • Anti-tumor Drug Targets Analysis: Current Insight and Future Prospect.

    abstract::The incidence and mortality of malignant tumors are on the rise, which has become the second leading cause of death in the world. At present, anti-tumor drugs are one of the most common methods for treating cancer. In recent years, with the in-depth study of tumor biology and related disciplines, it has been gradually...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450120666190402145325

    authors: Wang S,Zhou D,Xu Z,Song J,Qian X,Lv X,Luan J

    更新日期:2019-01-01 00:00:00

  • Thrombomodulin links coagulation to inflammation and immunity.

    abstract::Thrombomodulin (TM) is a type 1 membrane bound glycoprotein that has a C-type lectin domain at its Nterminus, 6 copies of the epidermal growth factor-like (EGF) motif and serine/threonine rich domain carrying a glycosoaminoglycan external to the membrane. TM binds thrombin changing thrombin's substrate specificity fro...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945012799424606

    authors: Morser J

    更新日期:2012-03-01 00:00:00

  • Hedgehog signaling in the normal and neoplastic mammary gland.

    abstract::The hedgehog signal transduction network is a critical regulator of metazoan development. Inappropriate activation of this network is implicated in several different cancers, including breast. Genetic evidence in mice as well as molecular biological studies in human cells clearly indicate that activated signaling can ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945010792006753

    authors: Visbal AP,Lewis MT

    更新日期:2010-09-01 00:00:00

  • Recent advances in the discovery of metallo-β-lactamase inhibitors for β-lactam antibiotic-resistant reversing agents.

    abstract::The overuse of antibiotics which exerts the selective pressure for bacterial pathogens has facilitated the spread of antibiotics' resistance. Metallo-β-lactamases (MβLs) are zinc enzymes produced by an increasing number of bacterial pathogens. They can readily cleave carbapenems and most other β-lactams that are mains...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450115666140326094504

    authors: Guo Z,Ma S

    更新日期:2014-01-01 00:00:00

  • Cellular and Molecular Networks in Chronic Myeloid Leukemia: The Leukemic Stem, Progenitor and Stromal Cell Interplay.

    abstract::The use of imatinib, second and third generation ABL tyrosine kinase inhibitors (TKI) (i.e. dasatinib, nilotinib, bosutinib and ponatinib) made CML a clinically manageable and, in a small percentage of cases, a cured disease. TKI therapy also turned CML blastic transformation into a rare event; however, disease progre...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450117666160615074120

    authors: Perrotti D,Silvestri G,Stramucci L,Yu J,Trotta R

    更新日期:2017-01-01 00:00:00

  • Aging of Brain Related with Mitochondrial Dysfunctions.

    abstract::Advancing age presents a major challenge for the elderly population in terms of quality of life. The risk of cognitive impairment, motor in-coordination, and behavioral inconsistency due to neuronal damage is relatively higher in aging individuals of society. The brain, through its structural and functional integrity,...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450121999201209202247

    authors: Dhote V,Samundre P,Ganeshpurkar A,Upaganlawar A

    更新日期:2020-12-09 00:00:00

  • Endogenous Cardioprotective Agents: Role in Pre and Postconditioning.

    abstract::Cardiovascular diseases (CVD) are the leading cause of death, chronic illness and disability in Western countries. The most common cause of CVD derives from the harmful effects of acute myocardial ischemia and subsequent reperfusion injury. Cardioprotection against acute ischemia/ reperfusion injury is made possible b...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150309115536

    authors: Penna C,Granata R,Tocchetti CG,Gallo MP,Alloatti G,Pagliaro P

    更新日期:2015-01-01 00:00:00

  • Small interfering RNAs and antisense oligonucleotides for treatment of neurological diseases.

    abstract::The complexity of the central nervous system (CNS) exposes it to a number of different diseases, often caused by only small variations in gene sequence or expression level. Antisense oligonucleotides and RNA interference-mediated therapies hold great promise for the treatment of CNS diseases in which neurodegeneration...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450053344920

    authors: Forte A,Cipollaro M,Cascino A,Galderisi U

    更新日期:2005-02-01 00:00:00

  • Potential therapeutic targets for neurodegenerative diseases: lessons learned from calorie restriction.

    abstract::It is well known that calorie restriction (CR) can retard the aging process in organisms ranging from yeast to non-human primates, and delay the onset of numerous age-related diseases including neurodegenerative disorders. Translation of the knowledge gained from CR research in animal models to disease prevention stra...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450111007011281

    authors: Duan W,Ross CA

    更新日期:2010-10-01 00:00:00

  • PPARs: a potential target for a disease-modifying strategy in stroke.

    abstract::Stroke is one of the major causes of mortality and disability in adults in industrialized countries. Despite numerous preclinical studies and clinical trials in the field of cerebral ischemia, no pharmacological agent has been validated in the treatment of acute ischemic, except thrombolysis. Cerebral ischemia is not ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450111314070005

    authors: Ouk T,Potey C,Gautier S,Bastide M,Deplanque D,Staels B,Duriez P,Leys D,Bordet R

    更新日期:2013-06-01 00:00:00

  • Possible Effects of Dietary Anthocyanins on Diabetes and Insulin Resistance.

    abstract::Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In p...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666151001105230

    authors: Turrini E,Ferruzzi L,Fimognari C

    更新日期:2017-01-01 00:00:00

  • Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease.

    abstract::Epidemiological studies indicate that anti-inflammatory drugs, especially the non-steroidal anti-inflammatory drugs (NSAIDs), decrease the risk of developing Alzheimer's disease (AD). Their beneficial effects may be due to interference in the chronic inflammatory reaction, that takes place in AD. The best-characterize...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450033490902

    authors: Hoozemans JJ,Veerhuis R,Rozemuller AJ,Eikelenboom P

    更新日期:2003-08-01 00:00:00

  • HIV-1 TAT and IMMUNE DYSREGULATION in AIDS PATHOGENESIS: a THERAPEUTIC TARGET.

    abstract::The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this way it regulates e...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150825110658

    authors: Chiozzini C,Toschi E

    更新日期:2016-01-01 00:00:00

  • Molecular foundations for personalized therapy in prostate cancer.

    abstract::Prostate cancer is the most common and second most lethal cancer in men. The majority of prostate cancers are histologically similar to acinar adenocarcinomas and rely on androgen-dependent signaling for their development and progression. Androgen deprivation therapy is a mainstay of treatment regimens and we discuss ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450115666141229154500

    authors: Fisher KW,Montironi R,Lopez Beltran A,Moch H,Wang L,Scarpelli M,Williamson SR,Koch MO,Cheng L

    更新日期:2015-01-01 00:00:00

  • Advances in Inhibitors of FXa.

    abstract::Thromboembolic diseases such as deep vein thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI) and ischemic strokes are mainly responsible for people's morbidity and mortality and have severely affected the people's quality of life all over the world. According to WHO statistics, an average of 17 mill...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150518095533

    authors: Guo L,Ma S

    更新日期:2015-01-01 00:00:00

  • Dysregulation of LncRNAs in Placenta and Pathogenesis of Preeclampsia.

    abstract:BACKGROUND:Preeclampsia, a gestational disease characterized by hypertension and proteinuria twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic pathways remain lar...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450118666170404160000

    authors: Song X,Luo X,Gao Q,Wang Y,Gao Q,Long W

    更新日期:2017-01-01 00:00:00

  • Adaptors in toll-like receptor signaling and their potential as therapeutic targets.

    abstract::To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of T...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945012803530260

    authors: Ve T,Gay NJ,Mansell A,Kobe B,Kellie S

    更新日期:2012-10-01 00:00:00

  • Recent advances in targeted anti-vasculature therapy: the neuroblastoma model.

    abstract::Novel anti-vasculature strategies that are emerging for the treatment of cancer and for the inhibition of angiogenesis may be a promising new tool for the adjuvant therapy of malignant tumours. Over the last fifteen years, several reports have been published concerning the relationship between tumour progression and a...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945009789577954

    authors: Pastorino F,Di Paolo D,Loi M,Becherini P,Caffa I,Zorzoli A,Marimpietri D,Carosio R,Perri P,Montaldo PG,Brignole C,Pagnan G,Ribatti D,Allen TM,Ponzoni M

    更新日期:2009-10-01 00:00:00

  • Recent Advances in Computational Methods for Identifying Anticancer Peptides.

    abstract::Anticancer peptide (ACP) is a kind of small peptides that can kill cancer cells without damaging normal cells. In recent years, ACP has been pre-clinically used for cancer treatment. Therefore, accurate identification of ACPs will promote their clinical applications. In contrast to labor-intensive experimental techniq...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450119666180801121548

    authors: Feng P,Wang Z

    更新日期:2019-01-01 00:00:00

  • Diacylglycerol kinases as emerging potential drug targets for a variety of diseases.

    abstract::Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids, DAG and phosphatidic acid (PA), by phosphorylating (consuming) DAG to yield PA. Ten mammalian DGK isozymes have been identified to date. In addition to two or three cysteine-rich C1 domains (protein kinase C-like zinc finger stru...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945008785132394

    authors: Sakane F,Imai S,Kai M,Yasuda S,Kanoh H

    更新日期:2008-08-01 00:00:00

  • Targeting transcription: a new concept of anti-inflammatory therapy of airway diseases.

    abstract::Most pathological conditions that result in human diseases are associated with altered gene expression. With the advent of new technologies that might control gene expression and a broader knowledge of transcription factors and pathways, new strategies have emerged that offer promising first results for therapeutical ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006777435326

    authors: Quarcoo D,Hamelmann E

    更新日期:2006-06-01 00:00:00

  • Biomarkers, critical disease pathways, drug targets, and alternative medicine in male breast cancer.

    abstract::While breast cancer (BC) is commonest malignancy among female with highest death rate, male breast cancer (MBC) is very rare but exhibits highest cancer specific death in men and the incidences of MBCs are rising rapidly. Due to rarity of the disease, no detail information about biomarkers and drug targets available a...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945009787122842

    authors: Barh D

    更新日期:2009-01-01 00:00:00