Pancreatic Neoplasms and Autophagy.

abstract：:Androgen and androgen receptor (AR) play a critical role in the development of prostate cancer. Androgen deprivation therapy (ADT) has become the therapeutic mainstay for patients with metastatic prostate cancer. ADT can reduce the serum testosterone level from the normal range between 500 and 600 ng/dl to the castrat...

journal_title：Current drug targets

authors： Hara N,Nishiyama T

更新日期：2014-01-01 00:00:00

abstract：:Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of increased basal oxidative stress. Since this state of oxidative stress makes cancer cells vulnerable to agents that further augment ROS levels, the use of pro-oxidant agents is emerging as an exciting strategy to selectively targ...

journal_title：Current drug targets

authors： Martin-Cordero C,Leon-Gonzalez AJ,Calderon-Montano JM,Burgos-Moron E,Lopez-Lazaro M

更新日期：2012-07-01 00:00:00

abstract：:Prostate cancer is the most common and second most lethal cancer in men. The majority of prostate cancers are histologically similar to acinar adenocarcinomas and rely on androgen-dependent signaling for their development and progression. Androgen deprivation therapy is a mainstay of treatment regimens and we discuss ...

journal_title：Current drug targets

authors： Fisher KW,Montironi R,Lopez Beltran A,Moch H,Wang L,Scarpelli M,Williamson SR,Koch MO,Cheng L

更新日期：2015-01-01 00:00:00

abstract：:Immune-based inflammatory diseases involve immune related dysregulation in different sites of body, which includes rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, atherosclerosis, etc. Advancements in molecular research have facilitated investigation of their pathogenesis that is involved in infl...

journal_title：Current drug targets

authors： Rahman M,Beg S,Verma A,Kazmi I,Patel DK,Anwar F,Al Abbasi FA,Kumar V

更新日期：2017-01-01 00:00:00

abstract：:Seventy five percent of hospitalized patients with Crohn's disease suffer from malnutrition. One third of Crohn's disease patients have a body mass index below 20. Sixty percent of Crohn's disease patients have sarcopenia. However some inflammatory bowel disease (IBD) patients are obese or suffer from sarcopenic-obesi...

journal_title：Current drug targets

authors： Hebuterne X,Filippi J,Schneider SM

更新日期：2014-01-01 00:00:00

abstract：:The fibrinolytic system consists of a balance between rates of plasminogen activation and fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three distinct inhibitors of the fibrinolytic system that differently regulate these two steps are plasminogen activator inhibitor type-1 (PAI-...

journal_title：Current drug targets

authors： Urano T,Suzuki Y,Iwaki T,Sano H,Honkura N,Castellino FJ

更新日期：2019-01-01 00:00:00

abstract：:Long term treatment with antiepileptic drugs (AEDs) is the standard therapeutic approach to eradicate seizures. However, a small but significant number of patients fail AED treatment. Intrinsic drug resistance may depend on two main and not necessarily mutually exclusive mechanisms: 1) Loss of pharmacological target (...

journal_title：Current drug targets

authors： Marroni M,Marchi N,Cucullo L,Abbott NJ,Signorelli K,Janigro D

更新日期：2003-05-01 00:00:00

abstract：:The HIV-1 transactivator Tat protein plays a key role in AIDS pathogenesis. Besides the Tat role as activator of HIV-1 transcription, it exerts several important functions on infected and uninfected cells. In fact, HIV-1 Tat is released by infected cells and is taken up by neighboring cells. In this way it regulates e...

journal_title：Current drug targets

authors： Chiozzini C,Toschi E

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present article is to review the indications, the monitoring and the complications of sedation in the post-anaesthesia care unit (PACU). In this setting, sedation is often an unwanted side effect of anaesthetic drugs that delay discharge, however it could be specifically indicated. Such indications incl...

journal_title：Current drug targets

authors： De Gaudio AR,Rinaldi S

更新日期：2005-11-01 00:00:00

abstract：:With the development of modern assisted reproductive technology(ART), the treatment of infertility and the pregnant outcome by ART have been significantly improved. However, implantation failure, particularly the unexplained repeated implantation failure (RIF), is still the unsolved and principal problem to affect the...

journal_title：Current drug targets

authors： Li J,Liang X,Chen Z

更新日期：2013-07-01 00:00:00

abstract：:Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor's role in the adapted immunity and inflammation as well as the receptor's ...

journal_title：Current drug targets

authors： Rutkowska A,Dev KK,Sailer AW

更新日期：2016-01-01 00:00:00

abstract：:Breast cancer remains the leading cause of cancer death among females worldwide. It signifies a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Current treatment modalities, including surgery, radiotherapy, and adjuvant chemotherapy or hormone therapy, have not be...

journal_title：Current drug targets

authors： Sinha D,Biswas J,Sung B,Aggarwal BB,Bishayee A

更新日期：2012-12-01 00:00:00

abstract：:Using a portable infusion pump, intravenous opioid patient-controlled analgesia (PCA) permits a patient to self-deliver a small bolus of opioid to achieve prompt relief without over sedation. Use of PCA for pain management is increasing in hospitals, largely because it can provide equivalent or better analgesia than c...

journal_title：Current drug targets

authors： Mann C,Ouro-Bang'na F,Eledjam JJ

更新日期：2005-11-01 00:00:00

abstract：:In this review we focus on the impact of genetic admixture on pharmacogenomics in the American continent, where five centuries of intermarriage between Amerindians, European and Africans, resulted in the extensive population heterogeneity observed nowadays. We compare two alternative views of human genomic variation, ...

journal_title：Current drug targets

authors： Suarez-Kurtz G,Pena SD

更新日期：2006-12-01 00:00:00

abstract：:The α7-nAChR plays critical roles in numerous organs and cells by regulating highly organ and cell typespecific functions. In this special issue different Authors have contributed to clarify the different roles played by the α7- nAChR. Post-translational processes such as receptor "underactivation" or "overactivation"...

journal_title：Current drug targets

authors： Russo P,Cardinale A,Shuller H

更新日期：2012-05-01 00:00:00

abstract：:Nowadays, natural compounds of plant origin with anticancer effects have gained more attention because of their clinical safety and broad efficacy profiles. Autophagy is a multistep lysosomal degradation pathway that may have a unique potential for clinical benefit in the setting of cancer treatment. To retrieve artic...

journal_title：Current drug targets

authors： Forouzanfar F,Mousavi SH

更新日期：2020-01-01 00:00:00

abstract：:The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important role in the generation of pacemaker activity of cardiac sinoatrial node cells and immature cardiomyocytes. HCN channels are also present in adult atrial and ventricular cardiomyocytes, where the physiological role is currently und...

journal_title：Current drug targets

authors： Sartiani L,Romanelli MN,Mugelli A,Cerbai E

更新日期：2015-01-01 00:00:00

abstract：:The pivotal role of 5-HT in the control of appetite was formally proposed nearly 30 years ago. In particular endogenous hypothalamic 5-HT has been implicated in the processes of within meal satiation and the end state of post meal satiety. Of the numerous 5-HT receptor subtypes currently identified, 5-HT(1B) and 5-HT(...

journal_title：Current drug targets

authors： Halford JC,Harrold JA,Lawton CL,Blundell JE

更新日期：2005-03-01 00:00:00

abstract：:The genus Zanthoxylum (Rutaceae) comprises about 250 species, of which many are used as food, often as condiments, substituting pepper due to the pungent taste of fruits, seeds, leaves, and bark, and therapeutic remedies especially in Eastern Asian countries and in Central America. The whole plant is also consumed as ...

journal_title：Current drug targets

authors： Epifano F,Curini M,Marcotullio MC,Genovese S

更新日期：2011-12-01 00:00:00

abstract：:Prostaglandins serve as the connecting link between inflammation and cancer. mPGES1, the downstream enzyme in the prostaglandin pathway is considered a better target than COX-2 against the progression of cancer due to the cardiovascular and other complications associated with the inhibition of the latter. Despite the ...

journal_title：Current drug targets

authors： Ramanan M,Doble M

更新日期：2017-01-01 00:00:00

abstract：:Nicotine is one of the most abused substances worldwide and can cause several harmful effects on health. One of the harmful effects, which is often ignored, is osteoporosis. Smoking has been shown to cause a decrease in bone mineral density in humans. Animal studies have proven that nicotine exerts negative effects on...

journal_title：Current drug targets

authors： Mohamed N,Muhammad N,Shuid AN,Soelaiman IN

更新日期：2018-01-01 00:00:00

abstract：:Inflammatory bowel disease diagnostic and management algorithms continue to rapidly evolve. This is partly driven by advanced radiologic techniques that provide objective, non-invasive evaluations. The realms of information provided by radiology and endoscopy continue to be intertwined. This has led to the question of...

journal_title：Current drug targets

authors： Bruining DH

更新日期：2012-09-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are the leading cause of death, chronic illness and disability in Western countries. The most common cause of CVD derives from the harmful effects of acute myocardial ischemia and subsequent reperfusion injury. Cardioprotection against acute ischemia/ reperfusion injury is made possible b...

journal_title：Current drug targets

authors： Penna C,Granata R,Tocchetti CG,Gallo MP,Alloatti G,Pagliaro P

更新日期：2015-01-01 00:00:00

abstract：:Epidemiological studies indicate that anti-inflammatory drugs, especially the non-steroidal anti-inflammatory drugs (NSAIDs), decrease the risk of developing Alzheimer's disease (AD). Their beneficial effects may be due to interference in the chronic inflammatory reaction, that takes place in AD. The best-characterize...

journal_title：Current drug targets

authors： Hoozemans JJ,Veerhuis R,Rozemuller AJ,Eikelenboom P

更新日期：2003-08-01 00:00:00

abstract：:Candida species, in particular C. albicans, represent a major threat to immunocompromised patients. Able to exist as a commensal on mucosal surfaces of healthy individuals, these opportunistic fungi frequently cause superficial infections of mucosae and skin. Furthermore, in hospital settings, Candida species may caus...

journal_title：Current drug targets

authors： Mavor AL,Thewes S,Hube B

更新日期：2005-12-01 00:00:00

abstract：:The incidence of lung cancer in 2007 is estimated to be 213,380 with 160,390 deaths in the United States. It will contribute to 31% of male and 26% of female cancer-related deaths and is the largest cause of cancer-related mortality in both men and women. Despite some advances in the treatment of advanced non-small ce...

journal_title：Current drug targets

authors： Chen M,Shao W,He J,Wang D

更新日期：2010-01-01 00:00:00

abstract：:The production of reactive oxygen species is a normal part of cell physiology, but many internal and external stimuli are able to trigger the production of excess levels of oxidants that are potentially damaging. The threat of oxidative damage is particularly significant to DNA, as damaged bases can interfere with rep...

journal_title：Current drug targets

authors： Shaukat Z,Liu D,Hussain R,Khan M,Gregory SL

更新日期：2016-01-01 00:00:00

abstract：:Adenocarcinoma of the prostate is the most common type of cancer, excluding skin cancer, and the second leading cause of cancer death in adult men in the United States. The lifetime risk for developing symptomatic prostate cancer is one in five for an American man. A pivotal step in carcinogenesis is a shift in the ba...

journal_title：Current drug targets

authors： Bello-DeOcampo D,Tindall DJ

更新日期：2003-04-01 00:00:00

abstract：:Biomedical science is currently undergoing an epoch-marking transition from its classical phase to the post-genome era. The outstanding success of world-wide genome sequencing efforts, evidenced by the recent publication of the draft of the human genome, together with the completion of several genomes of eukaryotic mo...

journal_title：Current drug targets

authors： Nagl SB

更新日期：2002-10-01 00:00:00

abstract：:Inflammation is the most common pathology in many orthopedic diseases, such as: rheumatoid arthritis (RA), osteoarthritis (OA) and other reasons caused osteolysis. The leading factor of inflammation was considered as the differentiation of monocyte and the polarization of macrophage. However, cytokines and different c...

journal_title：Current drug targets

authors： Liu Y,Cao Y,Smith W,He B,Yan L

更新日期：2020-01-01 00:00:00