Abstract:
:Inflammatory bowel disease diagnostic and management algorithms continue to rapidly evolve. This is partly driven by advanced radiologic techniques that provide objective, non-invasive evaluations. The realms of information provided by radiology and endoscopy continue to be intertwined. This has led to the question of whether radiologic applications will continue to expand, and eventually replace endoscopy in inflammatory bowel disease assessments. The likely outcome, however, will not be replacement, but rather imaging tools that complement endoscopic evaluations to provide global disease damage and activity scores.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Bruining DHdoi
10.2174/138945012802429633subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1245-7issue
10eissn
1389-4501issn
1873-5592pii
CDT-EPUB-20120528-11journal_volume
13pub_type
杂志文章,评审abstract::Aldose reductase (AR) enzymatically transforms cytosolic glucose into sorbitol, a molecule that poorly penetrates cell membranes and is sometimes slowly metabolized. Hyperglycemia can cause intracellular accumulation of sorbitol and its metabolite, fructose, which can create osmotic swelling and cell dysfunction. Driv...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945008783431781
更新日期:2008-01-01 00:00:00
abstract::Prostate cancer is the most common and second most lethal cancer in men. The majority of prostate cancers are histologically similar to acinar adenocarcinomas and rely on androgen-dependent signaling for their development and progression. Androgen deprivation therapy is a mainstay of treatment regimens and we discuss ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666141229154500
更新日期:2015-01-01 00:00:00
abstract::Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a natural protein expressed in a wide range of tissues in our body. It is a promising anti-cancer agent due to its selective killing of cancer cells, rendering normal cells unharmed. However, resistance occurs either intrinsically or develops ove...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666200302124426
更新日期:2020-01-01 00:00:00
abstract::Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn's disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process cont...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945012804545452
更新日期:2012-12-01 00:00:00
abstract::The recent marketing of two selective cyclooxygenase-2 (COX-2) inhibitors, celecoxib and rofecoxib is remarkable considering that COX-2 was only discovered eight years ago as a growth factor- and cytokine-inducible gene. Concomitant with these pharmaceutical successes is the advances in our understanding of the molecu...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450013348830
更新日期:2001-03-01 00:00:00
abstract::The emergency of responsive drug delivery systems has contributed to the reduced cytotoxicity, the improved permeability in tissues and extended circulation time of the active drug. Of particular, enzyme-responsive nanoplatforms have attracted a lot due to the specificity and efficiency of an enzyme-catalyzed reaction...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450122666210114095614
更新日期:2021-01-13 00:00:00
abstract::Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the first step of proline degradation, during which ROS and/or ATP is generated. POX is widely distributed in living organisms and is responsible for a number of regulatory processes such as redox homeostasis, osmotic adaptation, cell signaling ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945011613151031150637
更新日期:2015-01-01 00:00:00
abstract::A group of oxytocinergic neurons originating in the paraventricular nucleus of the hypothalamus and projecting to extrahypothalamic brain areas (e.g. hippocampus, medulla oblongata and spinal cord) control penile erection. Activation of these neurons by dopamine and dopamine agonists, excitatory amino acids (N-methyl-...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450033347190
更新日期:2003-01-01 00:00:00
abstract::Anticancer peptide (ACP) is a kind of small peptides that can kill cancer cells without damaging normal cells. In recent years, ACP has been pre-clinically used for cancer treatment. Therefore, accurate identification of ACPs will promote their clinical applications. In contrast to labor-intensive experimental techniq...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450119666180801121548
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The incidence of inflammatory bowel disease (IBD) continues to rise worldwide and despite the advances on pharmacotherapy, the etiopathogenesis of Crohn's disease (CD) and ulcerative colitis (UC) remains underexplained. In this context, the migratory waves of the last decades created a challenging setting to...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666201119142045
更新日期:2020-11-19 00:00:00
abstract::Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkh...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160208145934
更新日期:2017-01-01 00:00:00
abstract::Baculoviruses have adapted novel tactics to transcribe their genes during the late stages of replication. These include a DNA-directed RNA polymerase which is evolutionarily divergent from cellular polymerases. The viral RNA polymerase is a multisubunit and multifunctional RNA polymerase that has the ability to recogn...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007782151324
更新日期:2007-10-01 00:00:00
abstract::RNA, as an intermediate in the production of every gene encoded protein and the genetic material of many pathogenic viruses, presents an attractive target for both biological and therapeutic manipulation. Despite its extensive involvement in living systems, its chemical diversity based on four units is relatively low ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450023347722
更新日期:2002-06-01 00:00:00
abstract::At one time, atherosclerosis was thought to be a simple lipid storage disease. However, it is now recognized as a chronic and progressive inflammation of the arterial wall. Gene deletion experiments in murine models of atherosclerosis that reduce the inflammatory process also reduce disease severity. Identifying the i...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007783220605
更新日期:2007-12-01 00:00:00
abstract::Circulating tumor cells (CTCs) have attracted interest as biomarkers of cancer metastases but only recently has a reliable method of CTC detection been developed. CTCs can be thought of as a liquid biopsy from the blood, and they can be used in pathological and molecular assays. CTCs may ideally replace metastatic tis...
journal_title:Current drug targets
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::Tuberculosis (TB) is an infectious disease caused by the pathogen Mycobacterium tuberculosis (M. tuberculosis), killing about two million people worldwide each year. An increase in the prevalence of drug-resistant strains of M. tuberculosis in the past decades has renewed focus on the development of new drugs that can...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314060009
更新日期:2013-06-01 00:00:00
abstract::It has been well recognized that inflammatory responses are part of pathogenesis for various disorders such as autoimmune diseases. For example, multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system that is presumably caused by activated T cells specific for myelin antigens. Rheuma...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945010790980321
更新日期:2010-04-01 00:00:00
abstract::Thromboembolic diseases such as deep vein thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI) and ischemic strokes are mainly responsible for people's morbidity and mortality and have severely affected the people's quality of life all over the world. According to WHO statistics, an average of 17 mill...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450116666150518095533
更新日期:2015-01-01 00:00:00
abstract::Family C of G-protein coupled receptors (GPCRs) from humans is constituted by eight metabotropic glutamate (mGlu(1-8)) receptors, two heterodimeric gamma-aminobutyric acid(B) (GABA(B)) receptors, a calcium-sensing receptor (CaR), three taste (T1R) receptors, a promiscuous L-alpha-amino acid receptor (GPRC6A), and five...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945007779315614
更新日期:2007-01-01 00:00:00
abstract::Inflammation is the most common pathology in many orthopedic diseases, such as: rheumatoid arthritis (RA), osteoarthritis (OA) and other reasons caused osteolysis. The leading factor of inflammation was considered as the differentiation of monocyte and the polarization of macrophage. However, cytokines and different c...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450120666191015211737
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Pediatric tumors remain the highest cause of death in developed countries. Research on novel therapeutic strategies with lesser side effects is of utmost importance. In this scenario, the role of Renin-Angiotensin System (RAS) axes, the classical one formed by angiotensinconverting enzyme (ACE), Angiotensin ...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121666200210124217
更新日期:2020-01-01 00:00:00
abstract::Radiation-induced myelosuppression remains a rate-limiting factor of radiotherapy and chemotherapy. Therefore, hematological targets of radiation damage are of great significance for radiation oncology and normal tissue injury and protection. Protection of hematopoietic stem and progenitor cells is pivotal. In order t...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111009011375
更新日期:2010-11-01 00:00:00
abstract::Inflammation plays a central role in chronic obstructive pulmonary disease (COPD). COPD related inflammation is less responsive to inhaled steroids compared to asthma. There are three major novel anti-inflammatory approaches to the management of COPD. The first approach is phosphodiesterase inhibitors, such as roflumi...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314020008
更新日期:2013-02-01 00:00:00
abstract::Histone deacetylases are a class of enzymes that play important roles in post translational modifications of histones by deacetylating the lysine residues as well as interacting with various non-histone proteins. This type of enzymes is closely related to oncogenesis and has been proved to be attractive targets for de...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450115666140306152642
更新日期:2014-06-01 00:00:00
abstract::The incidence of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis) is highest during the peak reproductive years, hence the increased concern with the safety of IBD drugs during pregnancy. Over the past 11 years, anti-TNF-alpha antibody therapy has emerged as a treatment approach for refractory IBD...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945010790309885
更新日期:2010-02-01 00:00:00
abstract::Pancreatic cancer is predicted to be the second deadliest malignancy (a median survival of 4-6 months and a 5-year survival of less than 5%) in the USA by 2020. Although current medical detection technologies have dramatically improved the survival rate for patients with other gastrointestinal malignancies, the dismal...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666160622220915
更新日期:2018-01-01 00:00:00
abstract::The prevalence of periodontitis is around 20-50% of global population. If not treated, it can cause of tooth loss. Periodontal treatment aims at preserving the patient's teeth from various methods, including infection control and restoring lost periodontal tissue. The periodontium has great biological regenerative pot...
journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450121999201105152639
更新日期:2020-11-05 00:00:00
abstract::Post-translational modification represents an important mechanism to regulate protein function in cardiac cells. Ubiquitin (Ub) and ubiquitin-like proteins (UBLs) are a family of protein modifiers that share a certain extent of sequence and structure similarity. Conjugation of Ub or UBLs to target proteins is dynamica...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450117666151209114608
更新日期:2018-01-01 00:00:00
abstract::Biomedical science is currently undergoing an epoch-marking transition from its classical phase to the post-genome era. The outstanding success of world-wide genome sequencing efforts, evidenced by the recent publication of the draft of the human genome, together with the completion of several genomes of eukaryotic mo...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450023347452
更新日期:2002-10-01 00:00:00
abstract::HIV-1 replicates by infecting new target cells either as cell-free viral particle or, much more efficiently, via cell-to-cell viral transmission. Cell-mediated viral spread, in which the infected cell directly transfers the viral particles to target cells via cell-cell contacts, in vitro is up to three orders of magni...
journal_title:Current drug targets
pub_type: 杂志文章
doi:
更新日期:2015-08-25 00:00:00