Abstract:
:Post-translational modification represents an important mechanism to regulate protein function in cardiac cells. Ubiquitin (Ub) and ubiquitin-like proteins (UBLs) are a family of protein modifiers that share a certain extent of sequence and structure similarity. Conjugation of Ub or UBLs to target proteins is dynamically regulated by a set of UBL-specific enzymes and modulates the physical and physiological properties of protein substrates. Ub and UBLs control a strikingly wide spectrum of cellular processes and not surprisingly are involved in the development of multiple human diseases including cardiac diseases. Further identification of novel UBL targets will expand our understanding of the functional diversity of UBL pathways in physiology and pathology. Here we review recent findings on the mechanisms, proteome and functions of a subset of UBLs and highlight their potential impacts on the development and progression of various forms of cardiac diseases.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
Li J,Johnson JA,Su Hdoi
10.2174/1389450117666151209114608subject
Has Abstractpub_date
2018-01-01 00:00:00pages
989-1002issue
9eissn
1389-4501issn
1873-5592pii
CDT-EPUB-72373journal_volume
19pub_type
杂志文章,评审abstract::Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen levels. The varying sensitivit...
journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章
doi:10.2174/1389450120666191015211737
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更新日期:2005-02-01 00:00:00
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journal_title:Current drug targets
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更新日期:2008-07-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
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更新日期:2003-07-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/1389450111314080006
更新日期:2013-07-01 00:00:00
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journal_title:Current drug targets
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doi:10.2174/138945007779940043
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journal_title:Current drug targets
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更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00