Animal models of carcinogenesis in inflamed colorectum: potential use in chemoprevention study.

abstract：:Transport molecules can significantly affect the pharmacodynamics and pharmacokinetics of drugs. An important transport molecule, the 170 kDa P-glycoprotein (Pgp), is constitutively expressed at several organ sites in the human body. Pgp is expressed at the blood-brain barrier, in the kidneys, liver, intestines and in...

journal_title：Current drug targets

authors： Liang XJ,Aszalos A

更新日期：2006-08-01 00:00:00

abstract：:Escalating resistance to almost every class of antibiotics is reducing the utility of currently available antimicrobial drugs. A part of this menace is attributed to poor pharmacokinetics and pharmacodynamics of the drug. Improvement in drug delivery is the most challenging task encountered by the pharmaceutical indus...

journal_title：Current drug targets

authors： Jamil B,Bokhari H,Imran M

更新日期：2017-01-01 00:00:00

abstract：:To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of T...

journal_title：Current drug targets

authors： Ve T,Gay NJ,Mansell A,Kobe B,Kellie S

更新日期：2012-10-01 00:00:00

abstract：:In this review we focus on the impact of genetic admixture on pharmacogenomics in the American continent, where five centuries of intermarriage between Amerindians, European and Africans, resulted in the extensive population heterogeneity observed nowadays. We compare two alternative views of human genomic variation, ...

journal_title：Current drug targets

authors： Suarez-Kurtz G,Pena SD

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Different clinical studies have given inconsistent results on whether the use of antipsychotics increases the risk of thromboembolism. In this paper, we reviewed all relevant literature to provide suggestions for clinical diagnosis and treatment. METHODS:PubMed, Web of Science, EMBASE, MEDLINE, Cochrane and...

journal_title：Current drug targets

authors： Dai L,Zuo Q,Chen F,Chen L,Shen Y

更新日期：2020-01-01 00:00:00

abstract：:The understanding of the neurobiological processes leading to major depressive disorder (MDD) is an active field of research in the scientific community. For years, the alteration of monoamine neurotransmission, in particular serotonin (5-HT), has been considered the most significant pathophysiological mechanism of th...

journal_title：Current drug targets

authors： Catena-Dell'Osso M,Rotella F,Dell'Osso A,Fagiolini A,Marazziti D

更新日期：2013-05-01 00:00:00

abstract：:The last decade has witnessed the introduction of a large number of novel, molecularly targeted agents into the therapeutic armamentarium against diverse forms of cancer, including leukemia. Such agents include signal transduction, cell cycle, histone deacetylase, Hsp90, proteasome, and Bcl-2 family member inhibitors,...

journal_title：Current drug targets

authors： Grant S,Dent P

更新日期：2007-06-01 00:00:00

abstract：:Hypertriglyceridaemia is associated with insulin resistance, hypertension, obesity and diabetes. The management of hypertriglyceridaemia and atherogenic dyslipidaemias increasingly involves the use of several drugs for different aspects of the metabolic syndrome. This review highlights the agents for treatment of bloo...

journal_title：Current drug targets

authors： Viljoen A,Wierzbicki AS

更新日期：2009-04-01 00:00:00

abstract：:Multidrug resistance (MDR) is a kind of acquired resistance of microorganisms and cancer cells to chemotherapic drugs that are characterized by different chemical structure and different mechanism of action. Classic MDR is the consequence of the over-expression of a variety of proteins that extrude the chemotherapic f...

journal_title：Current drug targets

authors： Teodori E,Dei S,Martelli C,Scapecchi S,Gualtieri F

更新日期：2006-07-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a natural protein expressed in a wide range of tissues in our body. It is a promising anti-cancer agent due to its selective killing of cancer cells, rendering normal cells unharmed. However, resistance occurs either intrinsically or develops ove...

journal_title：Current drug targets

authors： Ngai SC

更新日期：2020-01-01 00:00:00

abstract：:Trypanosomes and Leishmaniae are the agents of several important parasitic diseases threatening hundreds of million human beings worldwide. As they diverged early in evolution, they display original molecular characteristics. These peculiarities are each defining putative specific targets for anti-parasitic drugs. Tra...

journal_title：Current drug targets

authors： Vanhamme L

更新日期：2008-11-01 00:00:00

abstract：:Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids, DAG and phosphatidic acid (PA), by phosphorylating (consuming) DAG to yield PA. Ten mammalian DGK isozymes have been identified to date. In addition to two or three cysteine-rich C1 domains (protein kinase C-like zinc finger stru...

journal_title：Current drug targets

authors： Sakane F,Imai S,Kai M,Yasuda S,Kanoh H

更新日期：2008-08-01 00:00:00

abstract：:Fracture healing is a process of recovering injured bone tissue forms and functions. Osteoporosis can delay the healing process, which contributes to personal suffering and loss of activities. Osteoporosis patients tend to lose bone mass at the metaphyseal region which require treatment to increase bone mass. Postmeno...

journal_title：Current drug targets

authors： Ibrahim N',Mohamed N,Shuid AN

更新日期：2013-12-01 00:00:00

abstract：:Most pathological conditions that result in human diseases are associated with altered gene expression. With the advent of new technologies that might control gene expression and a broader knowledge of transcription factors and pathways, new strategies have emerged that offer promising first results for therapeutical ...

journal_title：Current drug targets

authors： Quarcoo D,Hamelmann E

更新日期：2006-06-01 00:00:00

abstract：:Inflammation is the most common pathology in many orthopedic diseases, such as: rheumatoid arthritis (RA), osteoarthritis (OA) and other reasons caused osteolysis. The leading factor of inflammation was considered as the differentiation of monocyte and the polarization of macrophage. However, cytokines and different c...

journal_title：Current drug targets

authors： Liu Y,Cao Y,Smith W,He B,Yan L

更新日期：2020-01-01 00:00:00

abstract：:Treatment of chronic myeloid leukemia (CML) with interferon-alpha (IFN-α) was introduced in the early 1980s. Several clinical trials showed a survival advantage for patients treated with IFN-α compared to conventional chemotherapy. Some patients achieved longstanding complete cytogenetic remissions (i.e. >2 log tumor ...

journal_title：Current drug targets

authors： Simonsson B,Hjorth-Hansen H,Bjerrum OW,Porkka K

更新日期：2011-03-01 00:00:00

abstract：:PDZ domains play an essential role in a number of cellular processes by facilitating protein scaffolding and assembly of protein complexes. These domains consist of 80 to 90 amino acids and are found to recognize short C-terminal sequences of target proteins. Protein complex formation between PDZ target molecules can ...

journal_title：Current drug targets

authors： Holcomb J,Spellmon N,Trescott L,Sun F,Li C,Yang Z

更新日期：2015-01-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) metabolizes heme to generate carbon monoxide (CO), biliverdin, and iron. Biliverdin is subsequently metabolized to bilirubin by biliverdin reductase. HO-1 has recently emerged as a promising therapeutic target in the treatment of vascular disease. Pharmacological induction or gene transfer of H...

journal_title：Current drug targets

authors： Durante W

更新日期：2010-12-01 00:00:00

abstract：:One approach to identify new drugs with antimicrobial activities is to screen large libraries of molecules directly for their capacity to block the growth of bacterial or fungal monocultures. A more relevant way to assess both a product's efficacy and its potential cytotoxicity is undoubtedly to use an in vivo infecti...

journal_title：Current drug targets

authors： Squiban B,Kurz CL

更新日期：2011-06-01 00:00:00

abstract：:Currently, low density lipoprotein cholesterol (LDL-C) levels are the main, if not the only, lipid target in the effort to reduce cardiovascular disease (CVD) morbidity and mortality. Several primary and secondary CVD prevention trials with statins shaped current guidelines and provided detailed targets across a range...

journal_title：Current drug targets

authors： Athyros VG,Mikhailidis DP,Kakafika AI,Karagiannis A,Hatzitolios A,Tziomalos K,Ganotakis ES,Liberopoulos EN,Elisaf M

更新日期：2007-03-01 00:00:00

abstract：:Adenocarcinoma of the prostate is the most common type of cancer, excluding skin cancer, and the second leading cause of cancer death in adult men in the United States. The lifetime risk for developing symptomatic prostate cancer is one in five for an American man. A pivotal step in carcinogenesis is a shift in the ba...

journal_title：Current drug targets

authors： Bello-DeOcampo D,Tindall DJ

更新日期：2003-04-01 00:00:00

abstract：:Programmed cell death, commonly associated with the term apoptosis, is an integrated intracellular program that plays a critical role in lymphoid tissue homeostasis. Alterations in this highly regulated process is a common feature of most lymphoid malignancies, thus facilitating tumor escape from traditional chemother...

journal_title：Current drug targets

authors： Saborit-Villarroya I,Roué G,López-Guerra M,Alonso R,Xargay-Torrent S,Rosich L,Colomer D

更新日期：2010-07-01 00:00:00

abstract：:Breast cancer remains the leading cause of cancer death among females worldwide. It signifies a shift from the previous decade during which the most common cause of cancer death was cervical cancer. Current treatment modalities, including surgery, radiotherapy, and adjuvant chemotherapy or hormone therapy, have not be...

journal_title：Current drug targets

authors： Sinha D,Biswas J,Sung B,Aggarwal BB,Bishayee A

更新日期：2012-12-01 00:00:00

abstract：:Overexpression of the human epidermal growth factor receptor 2 (HER2) is identified in approximately 25- 30% of breast cancers and indicates a poor prognosis. Trastuzumab, the anti-HER2 monoclonal antibody (mAb), has shown significant clinical effects selectively in HER2-overexpressing metastatic breast cancer (MBC) w...

journal_title：Current drug targets

authors： Huang Y,Fu P,Fan W

更新日期：2013-07-01 00:00:00

abstract：:Infiltrating inflammatory cells into the kidney mediate the initiation and progression of damage by direct cytotoxicity, the secretion of soluble factors such as cytokines and proteases, or by the subsequent induction of further immune response. Before leukocytes can exert their effects on renal damage or repair, they...

journal_title：Current drug targets

authors： Panzer U,Steinmetz OM,Stahl RA,Wolf G

更新日期：2006-01-01 00:00:00

abstract：:The incidence and mortality of malignant tumors are on the rise, which has become the second leading cause of death in the world. At present, anti-tumor drugs are one of the most common methods for treating cancer. In recent years, with the in-depth study of tumor biology and related disciplines, it has been gradually...

journal_title：Current drug targets

authors： Wang S,Zhou D,Xu Z,Song J,Qian X,Lv X,Luan J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Some kinds of cations and anions are contained in body fluids such as blood, interstitial fluid, gastrointestinal juice, and tears at relatively high concentration. Ionresponsive drug delivery is available to design the unique dosage formulations which provide optimized drug therapy with effective, safe and ...

journal_title：Current drug targets

authors： Yoshida T,Shakushiro K,Sako K

更新日期：2018-02-08 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is a remarkably aggressive thoracic malignancy with a limited survival of only 5-12 months. However, MPM still remains unresponsive to conventional standards of treatment, including pleurectomy and decortication, extrapleural pneumonectomy for resectable disease with or without che...

journal_title：Current drug targets

authors： Cheng L,Li N,Xu XL,Mao WM

更新日期：2020-01-01 00:00:00

abstract：:Novel anti-vasculature strategies that are emerging for the treatment of cancer and for the inhibition of angiogenesis may be a promising new tool for the adjuvant therapy of malignant tumours. Over the last fifteen years, several reports have been published concerning the relationship between tumour progression and a...

journal_title：Current drug targets

authors： Pastorino F,Di Paolo D,Loi M,Becherini P,Caffa I,Zorzoli A,Marimpietri D,Carosio R,Perri P,Montaldo PG,Brignole C,Pagnan G,Ribatti D,Allen TM,Ponzoni M

更新日期：2009-10-01 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed that Cox-2 is over-expressed in cancer and stroma cells during tumor progression, and anti-cancer chemo-radiotherapies induce expression of Co...

journal_title：Current drug targets

authors： Khan Z,Khan N,Tiwari RP,Sah NK,Prasad GB,Bisen PS

更新日期：2011-06-01 00:00:00