Anti-tumor Drug Targets Analysis: Current Insight and Future Prospect.

Abstract:

:The incidence and mortality of malignant tumors are on the rise, which has become the second leading cause of death in the world. At present, anti-tumor drugs are one of the most common methods for treating cancer. In recent years, with the in-depth study of tumor biology and related disciplines, it has been gradually discovered that the essence of cell carcinogenesis is the infinite proliferation of cells caused by the disorder of cell signal transduction pathways, followed by a major shift in the concept of anti-tumor drugs research and development. The focus of research and development is shifting from traditional cytotoxic drugs to a new generation of anti-tumor drugs targeted at abnormal signaling system targets in tumor cells. In this review, we summarize the targets of anti-tumor drugs and analyse the molecular mechanisms of their effects, which lay a foundation for subsequent treatment, research and development.

journal_name

Curr Drug Targets

journal_title

Current drug targets

authors

Wang S,Zhou D,Xu Z,Song J,Qian X,Lv X,Luan J

doi

10.2174/1389450120666190402145325

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

1180-1202

issue

11

eissn

1389-4501

issn

1873-5592

pii

CDT-EPUB-97752

journal_volume

20

pub_type

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