TGF-betal/Smad signaling in prostate cancer.

abstract：:Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases. Pat...

journal_title：Current drug targets

authors： Improta G,Broccardo M

更新日期：2006-08-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by relatively selective degeneration of dopaminergic neurons in the substantia nigra and loss of dopamine in the striatum. More than 50 epidemiological studies confirmed the low incidence of PD in smokers. Examining the distribution of subtypes of nicotinic acetylcholine recep...

journal_title：Current drug targets

authors： Kawamata J,Suzuki S,Shimohama S

更新日期：2012-05-01 00:00:00

abstract：:Antiphospholipid syndrome (APS) is characterized by a combination of clinical features consisted of thrombotic or pregnancy-related events and autoimmune antiphospholipid antibodies. In the 1998 International Consensus Preliminary Criteria, APS is defined by the concomitant presence of these clinical features and labo...

journal_title：Current drug targets

authors： Nishiguchi T,Kobayashi T

更新日期：2005-08-01 00:00:00

abstract：:The emergency of responsive drug delivery systems has contributed to the reduced cytotoxicity, the improved permeability in tissues and extended circulation time of the active drug. Of particular, enzyme-responsive nanoplatforms have attracted a lot due to the specificity and efficiency of an enzyme-catalyzed reaction...

journal_title：Current drug targets

authors： Lou XF,Du YZ,Xu XL

更新日期：2021-01-13 00:00:00

abstract：:Mannosylphospho dolichol synthase (DPMS) catalyzes the transfer reaction GDP-mannose + Dol-P <--> Dol-P-Man + GDP, a 'key step' in the assembly of lipid-linked oligosaccharide (LLO) and a pre-requisite for asparagine-linked (N-linked) protein glycosylation. DPMS is present from a protozoan parasite to human, and its s...

journal_title：Current drug targets

authors： Baksi K,Tavárez-Pagán JJ,Martínez JA,Banerjee DK

更新日期：2008-04-01 00:00:00

abstract：:Virtual screening for active compounds has become an essential step within the drug development pipeline. The computer based prediction of compound binding modes is one of the most time and cost efficient methods for screening ligand libraries and enrich results of potential drugs. Here we present an overview about cu...

journal_title：Current drug targets

authors： Krüger J,Thiel P,Merelli I,Grunzke R,Gesing S

更新日期：2016-01-01 00:00:00

abstract：:Candida species, in particular C. albicans, represent a major threat to immunocompromised patients. Able to exist as a commensal on mucosal surfaces of healthy individuals, these opportunistic fungi frequently cause superficial infections of mucosae and skin. Furthermore, in hospital settings, Candida species may caus...

journal_title：Current drug targets

authors： Mavor AL,Thewes S,Hube B

更新日期：2005-12-01 00:00:00

abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons in the substantia nigra pars compacta (SNc). PD is a multifactorial disorder, with several different factors being suggested to play a synergistic pathophysiological role, inc...

journal_title：Current drug targets

authors： Tamtaji OR,Hadinezhad T,Fallah M,Shahmirzadi AR,Taghizadeh M,Behnam M,Asemi Z

更新日期：2020-01-01 00:00:00

abstract：:The incidence and mortality of malignant tumors are on the rise, which has become the second leading cause of death in the world. At present, anti-tumor drugs are one of the most common methods for treating cancer. In recent years, with the in-depth study of tumor biology and related disciplines, it has been gradually...

journal_title：Current drug targets

authors： Wang S,Zhou D,Xu Z,Song J,Qian X,Lv X,Luan J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Recently, there are scientific attempts to discover new drugs in the biotechnology industry in order to treat various diseases including atherosclerosis. OBJECTIVE:The main objective of the present review was to highlight the cellular, molecular biology and inflammatory process related to the atheromatous p...

journal_title：Current drug targets

authors： Thent ZC,Chakraborty C,Mahakkanukrauh P,Nik Ritza Kosai Nik Mahmood N,Rajan R,Das S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Prohibitin (PHB) is overtly conserved evolutionarily and ubiquitously expressed protein with pleiotropic functions in diverse cellular compartments. However, regulation and function of these proteins in different cells, tissues and in various diseases is different as evidenced by expression of these proteins...

journal_title：Current drug targets

authors： Chowdhury D,Kumar D,Sarma P,Tangutur AD,Bhadra MP

更新日期：2017-11-30 00:00:00

abstract：:Most pathological conditions that result in human diseases are associated with altered gene expression. With the advent of new technologies that might control gene expression and a broader knowledge of transcription factors and pathways, new strategies have emerged that offer promising first results for therapeutical ...

journal_title：Current drug targets

authors： Quarcoo D,Hamelmann E

更新日期：2006-06-01 00:00:00

abstract：:The Notch signaling plays a key role in cell differentiation, survival, and proliferation through diverse mechanisms. Thus, alterations of the Notch signaling can lead to a variety of disorders including human malignancies. Of considerable interest, recent evidence indicates that there is a significant cross-talk betw...

journal_title：Current drug targets

authors： Mo YY,Tang H,Miele L

更新日期：2013-09-01 00:00:00

abstract：:The α7-nAChR plays critical roles in numerous organs and cells by regulating highly organ and cell typespecific functions. In this special issue different Authors have contributed to clarify the different roles played by the α7- nAChR. Post-translational processes such as receptor "underactivation" or "overactivation"...

journal_title：Current drug targets

authors： Russo P,Cardinale A,Shuller H

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The Coronavirus Disease 2019 (COVID-19) is becoming the major health issue in recent human history with thousands of deaths and millions of cases worldwide. Newer research and old experience with other corona-viruses highlighted a probable underlying mechanism of disturbance of the renin-angiotensin system (...

journal_title：Current drug targets

authors： Vieira C,Nery L,Martins L,Jabour L,Dias R,Simões E Silva AC

更新日期：2020-10-20 00:00:00

abstract：:Heme oxygenase-1 (HO-1) metabolizes heme to generate carbon monoxide (CO), biliverdin, and iron. Biliverdin is subsequently metabolized to bilirubin by biliverdin reductase. HO-1 has recently emerged as a promising therapeutic target in the treatment of vascular disease. Pharmacological induction or gene transfer of H...

journal_title：Current drug targets

authors： Durante W

更新日期：2010-12-01 00:00:00

abstract：:Type 2 diabetes, which has dramatically increased during the last decade normally results from a combination of pancreatic beta cell dysfunction and insulin resistance. One of the most recent risk factors identified for type 2 diabetes is a sub-optimal fetal and neonatal environment. Numerous human epidemiological stu...

journal_title：Current drug targets

authors： Reusens B,Ozanne SE,Remacle C

更新日期：2007-08-01 00:00:00

abstract：:With the development of modern assisted reproductive technology(ART), the treatment of infertility and the pregnant outcome by ART have been significantly improved. However, implantation failure, particularly the unexplained repeated implantation failure (RIF), is still the unsolved and principal problem to affect the...

journal_title：Current drug targets

authors： Li J,Liang X,Chen Z

更新日期：2013-07-01 00:00:00

abstract：:Bacterial respiratory infections are the main reason of morbidity and mortality among cystic fibrosis (CF) patients. In early childhood, the respiratory infections are due to Staphylococcus aureus and Haemophilus influenzae. In older CF patients, pathogenic Gram-negative bacteria like Achromobacter xylosoxidans, Burkh...

journal_title：Current drug targets

authors： Velikova N,Wells JM

更新日期：2017-01-01 00:00:00

abstract：:The sialyltransferase family represents a group of enzymes that transfers sialic acid from its common nucleotide sugar donor, CMP-NeuAc, to the terminal carbohydrates group of various glycoproteins and glycolipids. Cloning of these enzymes from mammalian sources indicated these are all type II membrane proteins with t...

journal_title：Current drug targets

authors： Datta AK

更新日期：2009-06-01 00:00:00

abstract：:Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn's disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process cont...

journal_title：Current drug targets

authors： Tanaka T

更新日期：2012-12-01 00:00:00

abstract：:Vascular Disrupting Agents (VDA) are a potential new class of oncology drugs that have garnered attention recently as a number of these agents have entered into Phase 2-3 studies. Currently available data suggest how the subsequent evolution of these agents into clinical practice may proceed, with new therapeutic para...

journal_title：Current drug targets

authors： Spear MA,LoRusso P,Mita A,Mita M

更新日期：2011-12-01 00:00:00

abstract：:Currently, low density lipoprotein cholesterol (LDL-C) levels are the main, if not the only, lipid target in the effort to reduce cardiovascular disease (CVD) morbidity and mortality. Several primary and secondary CVD prevention trials with statins shaped current guidelines and provided detailed targets across a range...

journal_title：Current drug targets

authors： Athyros VG,Mikhailidis DP,Kakafika AI,Karagiannis A,Hatzitolios A,Tziomalos K,Ganotakis ES,Liberopoulos EN,Elisaf M

更新日期：2007-03-01 00:00:00

abstract：:Efforts to interfere with the initiation and promotion of breast and other cancers by endocrine manipulation are not new. It is of obvious benefit to cancer patients to administer substances that combine minimal general toxicity with maximal oestrogen inhibition. Raloxifene is a relatively recent addition to a group o...

journal_title：Current drug targets

authors： Kellen JA

更新日期：2001-12-01 00:00:00

abstract：:Thrombomodulin (TM) is a type 1 membrane bound glycoprotein that has a C-type lectin domain at its Nterminus, 6 copies of the epidermal growth factor-like (EGF) motif and serine/threonine rich domain carrying a glycosoaminoglycan external to the membrane. TM binds thrombin changing thrombin's substrate specificity fro...

journal_title：Current drug targets

authors： Morser J

更新日期：2012-03-01 00:00:00

abstract：:While breast cancer (BC) is commonest malignancy among female with highest death rate, male breast cancer (MBC) is very rare but exhibits highest cancer specific death in men and the incidences of MBCs are rising rapidly. Due to rarity of the disease, no detail information about biomarkers and drug targets available a...

journal_title：Current drug targets

authors： Barh D

更新日期：2009-01-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threating conditions still lacking a definite therapy and carrying a high mortality and morbidity, especially in children and infants. Albeit respiratory assistance and supportive therapies are crucial for ALI/ARDS, many drugs have been pr...

journal_title：Current drug targets

authors： De Luca D,Piastra M,Tosi F,Pulitanò S,Mancino A,Genovese O,Pietrini D,Conti G

更新日期：2012-06-01 00:00:00

abstract：:In this review we focus on the impact of genetic admixture on pharmacogenomics in the American continent, where five centuries of intermarriage between Amerindians, European and Africans, resulted in the extensive population heterogeneity observed nowadays. We compare two alternative views of human genomic variation, ...

journal_title：Current drug targets

authors： Suarez-Kurtz G,Pena SD

更新日期：2006-12-01 00:00:00

abstract：:The last decade has witnessed the introduction of a large number of novel, molecularly targeted agents into the therapeutic armamentarium against diverse forms of cancer, including leukemia. Such agents include signal transduction, cell cycle, histone deacetylase, Hsp90, proteasome, and Bcl-2 family member inhibitors,...

journal_title：Current drug targets

authors： Grant S,Dent P

更新日期：2007-06-01 00:00:00

abstract：:The down regulation of gene expression is a promising strategy for molecular medicine and experimental biology. Molecules that bind to the DNA double helix may interfere with gene expression and, in addition to potential therapeutic applications, can be helpful for the investigation of DNA processing, chromatin packag...

journal_title：Current drug targets

authors： Besch R,Giovannangeli C,Degitz K

更新日期：2004-11-01 00:00:00