Tachykinins: role in human gastrointestinal tract physiology and pathology.

Abstract:

:Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases. Pathophysiological implications of TKs in the digestive tract include changes in TK innervation, in the expression of TKs and TK receptors, which result in inflammation- and immune-induced disturbances of gut functions, such as dysmotility (diarrhoea/constipation), secretory diarrhoea and visceral hyperalgesia. Increasing evidence correlates all these TKergic system abnormalities with gastrointestinal diseases of different etiology (i.e. inflammatory bowel diseases, irritable bowel syndrome). Accordingly, TK receptors have been identified as novel targets for the development of new therapeutic agents for clinical use. Available preclinical findings have shown that TK antagonists could counteract the most significant symptoms characterizing these gut diseases.

journal_name

Curr Drug Targets

journal_title

Current drug targets

authors

Improta G,Broccardo M

doi

10.2174/138945006778019354

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

1021-9

issue

8

eissn

1389-4501

issn

1873-5592

journal_volume

7

pub_type

杂志文章,评审
  • Fetal determinants of type 2 diabetes.

    abstract::Type 2 diabetes, which has dramatically increased during the last decade normally results from a combination of pancreatic beta cell dysfunction and insulin resistance. One of the most recent risk factors identified for type 2 diabetes is a sub-optimal fetal and neonatal environment. Numerous human epidemiological stu...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945007781386866

    authors: Reusens B,Ozanne SE,Remacle C

    更新日期:2007-08-01 00:00:00

  • A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin.

    abstract:BACKGROUND:The plant milk thistle and silymarin has been traditionally used as a natural remedy for the treatment of various ailments including neurological disorders such as Alzheimer's and Parkinson's disease and cerebral ischemia for over 2000 years. OBJECTIVE:In this article we review the neuroprotective effects o...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450117666161227125121

    authors: Devi KP,Malar DS,Braidy N,Nabavi SM,Nabavi SF

    更新日期:2017-01-01 00:00:00

  • MicroRNAs in arterial remodelling, inflammation and atherosclerosis.

    abstract::Atherosclerosis is now widely appreciated to represent a chronic inflammatory reaction of the vascular wall in response to dyslipidemia and endothelial distress involving the inflammatory recruitment of leukocytes and the activation of resident vascular cells. The proliferative response of smooth muscle cells critical...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945010791591377

    authors: Weber C,Schober A,Zernecke A

    更新日期:2010-08-01 00:00:00

  • Recent Advances in Protein-Protein Docking.

    abstract::Protein-protein interactions (PPIs) play important roles in a variety of biological processes, and many PPIs have been regarded as biologically compelling targets for drug discovery. Extensive efforts have been made to develop feasible proteinprotein docking approaches to study PPIs in silico. Most of these approaches...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450117666160112112640

    authors: Zhang Q,Feng T,Xu L,Sun H,Pan P,Li Y,Li D,Hou T

    更新日期:2016-01-01 00:00:00

  • Antioxidants as a Potential Preventive and Therapeutic Strategy for Cadmium.

    abstract::Epidemiological studies provide a growing number of evidences that chronic exposure to relatively low levels of cadmium (Cd), nowadays taking place in industrialized countries, may cause health hazard. Thus, growing interest has been focused on effective ways of protection from adverse effects of exposure to this heav...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450116666150506114336

    authors: Brzóska MM,Borowska S,Tomczyk M

    更新日期:2016-01-01 00:00:00

  • Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy.

    abstract::Hypertension is usually associated with deficient nitric oxide (NO) bioavailability, and therefore stimulating NO activity is an important antihypertensive strategy. Recently, many studies have shown that both nitrite and nitrate anions are not simple products of NO metabolism and indeed may be reduced back to NO. Whi...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450119666180816120816

    authors: Oliveira-Paula GH,Tanus-Santos JE

    更新日期:2019-01-01 00:00:00

  • Targeting PPAR isoforms following CNS injury.

    abstract::A major focus has developed for the discovery of proregenerative and neuroprotective therapeutic agents to help the millions of Americans who receive a CNS injury annually. Tribulations have been encountered along the way due to the complicated set of pathways that are initiated post-injury. To target this complicated...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450111314070003

    authors: Yonutas HM,Sullivan PG

    更新日期:2013-06-01 00:00:00

  • Gene therapy for arthritis.

    abstract::Recent progress in molecular biology has provided application of gene transfer methods in arthritis. Two clinical trails using ex vivo retrovirus mediated delivery of interleukin -1 receptor antagonist gene for rheumatoid arthritis has begun in USA and Germany. However, there are still many issues to be elucidated; on...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450033490777

    authors: Tomita T,Hashimoto H,Yoshikawa H

    更新日期:2003-11-01 00:00:00

  • Pharmacological treatments for neovascular age-related macular degeneration: can mixed treatment comparison meta-analysis be useful?

    abstract:OBJECTIVE:To investigated the use of mixed treatment comparison (MTC) meta-analysis models to summarize results from randomized clinical trials (RCTs) on approved pharmacological treatments for neovascular age-related macular degeneration (AMD). METHODS:The number of patients with visual loss or visual gain of 3 or mo...

    journal_title:Current drug targets

    pub_type: 杂志文章,meta分析,评审

    doi:10.2174/138945011794182665

    authors: Virgili G,Novielli N,Menchini F,Murro V,Giacomelli G

    更新日期:2011-02-01 00:00:00

  • Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer.

    abstract::Resveratrol (3,4',5 tri-hydroxystilbene) is a phytoalexin produced in hudge amount in grapevine skin in response to infection by Bothrytis cinerea. This production of resveratrol blocks the proliferation of the pathogen, thereby acting as a natural antibiotic. Numerous studies have reported interesting properties of t...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006776359331

    authors: Delmas D,Lançon A,Colin D,Jannin B,Latruffe N

    更新日期:2006-04-01 00:00:00

  • Reducing the risk of major elective non-cardiac surgery: is there a role for levosimendan in the preoperative optimization of cardiac function?

    abstract::Patients with heart failure undergoing non-cardiac surgery still have an unacceptably high morbidity and mortality. Compromised myocardial physiologic reserves in combination with extensive surgery and anesthesia appear to play a crucial role in determining high perioperative morbidity and mortality. Nevertheless, sev...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/138945009789108819

    authors: Morelli A,Ertmer C,Pietropaoli P,Westphal M

    更新日期:2009-09-01 00:00:00

  • Animal models of carcinogenesis in inflamed colorectum: potential use in chemoprevention study.

    abstract::Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn's disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process cont...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945012804545452

    authors: Tanaka T

    更新日期:2012-12-01 00:00:00

  • Dysregulation of LncRNAs in Placenta and Pathogenesis of Preeclampsia.

    abstract:BACKGROUND:Preeclampsia, a gestational disease characterized by hypertension and proteinuria twenty weeks into pregnancy, is one of the leading causes of fetal and maternal mortality. Although multiple genetic and environmental factors are found to be related to the preeclampsia risk, the pathogenic pathways remain lar...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450118666170404160000

    authors: Song X,Luo X,Gao Q,Wang Y,Gao Q,Long W

    更新日期:2017-01-01 00:00:00

  • Decreasing the metastatic potential in cancers--targeting the heparan sulfate proteoglycans.

    abstract::The heterogeneity of proteoglycans (PG)s contributes to their functional diversity. Many functions depend on their ability to bind and modulate the activity of components of the extracellular matrix (ECM). The ability of PGs to interact with other molecules, such as growth factors, is largely determined by the fine st...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450054863662

    authors: Fjeldstad K,Kolset SO

    更新日期:2005-09-01 00:00:00

  • Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders.

    abstract::There exists an immediate need to develop novel medications for the treatment of mood disorders such as bipolar disorder and depression. Initial interest in glycogen synthase kinase-3 (GSK-3) as a target for the treatment of mood disorders arose from the finding that the mood stabilizing drug lithium directly inhibite...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450110607011399

    authors: Gould TD,Picchini AM,Einat H,Manji HK

    更新日期:2006-11-01 00:00:00

  • Biomarkers, critical disease pathways, drug targets, and alternative medicine in male breast cancer.

    abstract::While breast cancer (BC) is commonest malignancy among female with highest death rate, male breast cancer (MBC) is very rare but exhibits highest cancer specific death in men and the incidences of MBCs are rising rapidly. Due to rarity of the disease, no detail information about biomarkers and drug targets available a...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945009787122842

    authors: Barh D

    更新日期:2009-01-01 00:00:00

  • Microdialysis approach to study serotonin outflow in mice following selective serotonin reuptake inhibitors and substance P (neurokinin 1) receptor antagonist administration: a review.

    abstract::Classical antidepressant drugs such as Selective Serotonin Reuptake Inhibitors (SSRIs) display several disadvantages, e.g., the onset of action (2 to 3 weeks) to start clinical benefits is too long, and a significant proportion of patients do not respond to this monotherapy. Several strategies have been proposed to ov...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006775515428

    authors: Guiard BP,Lanfumey L,Gardier AM

    更新日期:2006-02-01 00:00:00

  • Hematological targets of radiation damage.

    abstract::Radiation-induced myelosuppression remains a rate-limiting factor of radiotherapy and chemotherapy. Therefore, hematological targets of radiation damage are of great significance for radiation oncology and normal tissue injury and protection. Protection of hematopoietic stem and progenitor cells is pivotal. In order t...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450111009011375

    authors: Kulkarni S,Ghosh SP,Hauer-Jensen M,Kumar KS

    更新日期:2010-11-01 00:00:00

  • From "An Enzyme Able to Destroy Penicillin" to Carbapenemases: 70 Years of Beta-lactamase Misbehaviour.

    abstract::As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They produced a penicillinase that could hydrolyze the amide bond in the β-lactam ring. Later, an enzyme mediated by an R-...

    journal_title:Current drug targets

    pub_type: 历史文章,杂志文章,评审

    doi:10.2174/1389450116666151001112859

    authors: Frère JM,Sauvage E,Kerff F

    更新日期:2016-01-01 00:00:00

  • Clinical aspects of natural anti-angiogenic drugs.

    abstract::Natural products represent a rich resource for drug delivery and are currently being exploited to target tumour angiogenesis. A vast array of products of natural origin have been shown to have anti-angiogenic potential in preclinical models, including purified endogenous inhibitors, and exogenous compounds derived fro...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006776054951

    authors: Neal CP,Berry DP,Doucas H,Manson MM,Steward W,Garcea G

    更新日期:2006-03-01 00:00:00

  • Recent advances in the discovery of metallo-β-lactamase inhibitors for β-lactam antibiotic-resistant reversing agents.

    abstract::The overuse of antibiotics which exerts the selective pressure for bacterial pathogens has facilitated the spread of antibiotics' resistance. Metallo-β-lactamases (MβLs) are zinc enzymes produced by an increasing number of bacterial pathogens. They can readily cleave carbapenems and most other β-lactams that are mains...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450115666140326094504

    authors: Guo Z,Ma S

    更新日期:2014-01-01 00:00:00

  • Genomic databases and the search of protein targets for protozoan parasites.

    abstract::The development of databases devoted to biological information opened the possibility to integrate, query and analyze biological data obtained from several sources that otherwise would be scattered through the web. Several issues arise in the handling of biological information, mainly due to the diversity of biologica...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945009787581195

    authors: Timmers LF,Pauli I,Barcellos GB,Rocha KB,Caceres RA,de Azevedo WF Jr,Soares MB

    更新日期:2009-03-01 00:00:00

  • Targeting Autophagic Pathways by Plant Natural Compounds in Cancer Treatment.

    abstract::Nowadays, natural compounds of plant origin with anticancer effects have gained more attention because of their clinical safety and broad efficacy profiles. Autophagy is a multistep lysosomal degradation pathway that may have a unique potential for clinical benefit in the setting of cancer treatment. To retrieve artic...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450121666200504072635

    authors: Forouzanfar F,Mousavi SH

    更新日期:2020-01-01 00:00:00

  • Try to Remember: Interplay between Memory and Substance Use Disorder.

    abstract::Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insi...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450118666170622092824

    authors: Mohamed RMP,Kumar J,Yap E,Mohamed IN,Sidi H,Adam RL,Das S

    更新日期:2019-01-01 00:00:00

  • Anti-TNF antibody therapy for inflammatory bowel disease during pregnancy: a clinical review.

    abstract::The incidence of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis) is highest during the peak reproductive years, hence the increased concern with the safety of IBD drugs during pregnancy. Over the past 11 years, anti-TNF-alpha antibody therapy has emerged as a treatment approach for refractory IBD...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945010790309885

    authors: El Mourabet M,El-Hachem S,Harrison JR,Binion DG

    更新日期:2010-02-01 00:00:00

  • Sedation in PACU: indications, monitoring, complications.

    abstract::The aim of the present article is to review the indications, the monitoring and the complications of sedation in the post-anaesthesia care unit (PACU). In this setting, sedation is often an unwanted side effect of anaesthetic drugs that delay discharge, however it could be specifically indicated. Such indications incl...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945005774574542

    authors: De Gaudio AR,Rinaldi S

    更新日期:2005-11-01 00:00:00

  • Pharmacogenomics in the Americas: the impact of genetic admixture.

    abstract::In this review we focus on the impact of genetic admixture on pharmacogenomics in the American continent, where five centuries of intermarriage between Amerindians, European and Africans, resulted in the extensive population heterogeneity observed nowadays. We compare two alternative views of human genomic variation, ...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006779025392

    authors: Suarez-Kurtz G,Pena SD

    更新日期:2006-12-01 00:00:00

  • Trabectedin (Yondelis®) as a Therapeutic Option in Gynecological Cancers: A Focus on its Mechanisms of Action, Clinical Activity and Genomic Predictors of Drug Response.

    abstract::The use of predictive biomarkers provides potential individualized cancer therapeutic options to prevent therapy failure as well as serious toxicities. Several recent studies showed that predictive and prognostic biomarkers are a notable personalized strategy to improve patients' care in several cancers. Trabectedin (...

    journal_title:Current drug targets

    pub_type: 杂志文章

    doi:10.2174/1389450121666200128161733

    authors: Souid S,Aissaoui D,Srairi-Abid N,Essafi-Benkhadir K

    更新日期:2020-01-01 00:00:00

  • The functions and structure of ABC transporters: implications for the design of new inhibitors of Pgp and MRP1 to control multidrug resistance (MDR).

    abstract::Multidrug resistance (MDR) is a kind of acquired resistance of microorganisms and cancer cells to chemotherapic drugs that are characterized by different chemical structure and different mechanism of action. Classic MDR is the consequence of the over-expression of a variety of proteins that extrude the chemotherapic f...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/138945006777709520

    authors: Teodori E,Dei S,Martelli C,Scapecchi S,Gualtieri F

    更新日期:2006-07-01 00:00:00

  • Discovery and design of selective cyclooxygenase-2 inhibitors as non-ulcerogenic, anti-inflammatory drugs with potential utility as anti-cancer agents.

    abstract::The recent marketing of two selective cyclooxygenase-2 (COX-2) inhibitors, celecoxib and rofecoxib is remarkable considering that COX-2 was only discovered eight years ago as a growth factor- and cytokine-inducible gene. Concomitant with these pharmaceutical successes is the advances in our understanding of the molecu...

    journal_title:Current drug targets

    pub_type: 杂志文章,评审

    doi:10.2174/1389450013348830

    authors: Kalgutkar AS,Zhao Z

    更新日期:2001-03-01 00:00:00