Abstract:
:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threating conditions still lacking a definite therapy and carrying a high mortality and morbidity, especially in children and infants. Albeit respiratory assistance and supportive therapies are crucial for ALI/ARDS, many drugs have been proposed to treat such syndromes through various mechanisms of action. On the whole the pharmacological therapy might play an important role in such a complex clinical situation but few evidence based data are available in pediatric and neonatal critical care. This review will focus on drugs directly available on the bedside, that is, medicines already administered in the practice or investigated in at least one clinical study. We will value the differences due to patient's age and the various causes of the syndrome, that may affect the response to the pharmacological therapy. A special attention will be given to the drugs directly deliverable into the lungs, as this strategy allows a total availability to the lung tissue. The experimental background behind each drug will be discussed and then clinical data in neonates and infants will be presented, if available. Data coming from adult critical care and thought to be somehow pertinent for the pediatric setting will otherwise be reviewed. Quality and evidence for or against each therapy will be evaluated according to the Scottish Intercollegiate Guidelines Network statement and practical reminders for clinicians will accordingly be provided.
journal_name
Curr Drug Targetsjournal_title
Current drug targetsauthors
De Luca D,Piastra M,Tosi F,Pulitanò S,Mancino A,Genovese O,Pietrini D,Conti Gdoi
10.2174/138945012800675687subject
Has Abstractpub_date
2012-06-01 00:00:00pages
906-16issue
7eissn
1389-4501issn
1873-5592pii
CDT-EPUB-20120418-006journal_volume
13pub_type
杂志文章,评审abstract::The aim of the present article is to review the indications, the monitoring and the complications of sedation in the post-anaesthesia care unit (PACU). In this setting, sedation is often an unwanted side effect of anaesthetic drugs that delay discharge, however it could be specifically indicated. Such indications incl...
journal_title:Current drug targets
pub_type: 杂志文章,评审
doi:10.2174/138945005774574542
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
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journal_title:Current drug targets
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
abstract::The Wnt signaling pathway has important functions in development, tissue homeostasis, and regeneration. Deregulation of canonical Wnt/beta-catenin signaling is frequently found in various human cancers, particularly in colorectal cancer, and non-canonical Wnt signaling pathways also have been implicated in neoplasia. ...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2008-07-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2018-02-08 00:00:00
abstract::Alzheimer's disease (AD) has become linked to inflammation and metal biology. Metals (copper, zinc and iron) and inflammatory cytokines are significant factors that increase the onset of sporadic late onset forms of the dementia. The genetic discovery that alleles in the hemochromatosis gene accelerate the onset of di...
journal_title:Current drug targets
pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00