Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease.

Abstract:

:Epidemiological studies indicate that anti-inflammatory drugs, especially the non-steroidal anti-inflammatory drugs (NSAIDs), decrease the risk of developing Alzheimer's disease (AD). Their beneficial effects may be due to interference in the chronic inflammatory reaction, that takes place in AD. The best-characterized action of NSAIDs is the inhibition of cyclooxygenase (COX). There is special interest for anti-inflammatory treatment of AD using selective COX-2 inhibitors. These inhibitors reduce the inflammatory reaction but lack the side effects observed with non-selective NSAIDs. So far, clinical trials designed to inhibit inflammation or COX-2 activity have failed in the treatment of AD patients. Several lines of evidence can explain the failures of the anti-inflammatory and anti-COX-2 trials on AD patients. In this review we will focus on the role, expression and regulation of COX-1 and COX-2 in AD brain. Understanding the role of COX in AD pathogenesis could contribute to the development of an anti-inflammatory therapy for the treatment or prevention of AD.

journal_name

Curr Drug Targets

journal_title

Current drug targets

authors

Hoozemans JJ,Veerhuis R,Rozemuller AJ,Eikelenboom P

doi

10.2174/1389450033490902

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

461-8

issue

6

eissn

1389-4501

issn

1873-5592

journal_volume

4

pub_type

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