Unique structural motif supports mannosylphospho dolichol synthase: an important angiogenesis regulator.

abstract：:Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during pathological gut diseases. Pat...

journal_title：Current drug targets

authors： Improta G,Broccardo M

更新日期：2006-08-01 00:00:00

abstract：:Pancreatic cancer is predicted to be the second deadliest malignancy (a median survival of 4-6 months and a 5-year survival of less than 5%) in the USA by 2020. Although current medical detection technologies have dramatically improved the survival rate for patients with other gastrointestinal malignancies, the dismal...

journal_title：Current drug targets

authors： Barton LA,Ren J

更新日期：2018-01-01 00:00:00

abstract：:Memories associated with substance use disorders, or substance-associated cues increase the likelihood of craving and relapse during abstinence. There is a growing consensus that manipulation of synaptic plasticity may reduce the strength of substance abuse-related memories. On the biological front, there are new insi...

journal_title：Current drug targets

authors： Mohamed RMP,Kumar J,Yap E,Mohamed IN,Sidi H,Adam RL,Das S

更新日期：2019-01-01 00:00:00

abstract：:Autophagy is a process the primary role of which is to clear up damaged cellular components such as long-lived proteins and organelles, thus participating in the conservation of different cells. Osteoporosis associated with aging is characterized by consistent changes in bone metabolism with suppression of bone format...

journal_title：Current drug targets

authors： Wang T,He H,Liu S,Jia C,Fan Z,Zhong C,Yu J,Liu H,He C

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Global death rate due to cardiovascular diseases (CVDs) is highest as compared to other ailments. Principal risk factor associated with CVDs is hypertension. Major classes of current antihypertensive (AHT) therapies include angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs)...

journal_title：Current drug targets

authors： Niaz T,Hafeez Z,Imran M

更新日期：2017-01-01 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed that Cox-2 is over-expressed in cancer and stroma cells during tumor progression, and anti-cancer chemo-radiotherapies induce expression of Co...

journal_title：Current drug targets

authors： Khan Z,Khan N,Tiwari RP,Sah NK,Prasad GB,Bisen PS

更新日期：2011-06-01 00:00:00

abstract：:Thromboembolic diseases such as deep vein thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI) and ischemic strokes are mainly responsible for people's morbidity and mortality and have severely affected the people's quality of life all over the world. According to WHO statistics, an average of 17 mill...

journal_title：Current drug targets

authors： Guo L,Ma S

更新日期：2015-01-01 00:00:00

abstract：:Over the past years, there was an explosion in the knowledge of the protein target and molecular mechanism associated with various disease types and in the new research of drugs of natural origin. The key idea is to evaluate bioactive natural products interacting with protein domains of different genetic origin but st...

journal_title：Current drug targets

authors： Braca A,Dal Piaz F,Marzocco S,Autore G,Vassallo A,De Tommasi N

更新日期：2011-03-01 00:00:00

abstract：:Our aim was to provide a narrative review regarding the prevalence, the associated pathophysiologic pathways and the potential management methods of sexual dysfunction related to ablative surgical techniques for Benign Prostatic Enlargement (BPE). Men suffering from BPE are at high risk of sexual dysfunction due to th...

journal_title：Current drug targets

authors： Mykoniatis I,Renterghem KV,Sokolakis I

更新日期：2021-01-01 00:00:00

abstract：:Neutrophil-dominated inflammation plays an important role in many airway diseases including asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and cystic fibrosis. In cases of asthma where neutrophil-dominated inflammation is a major contributing factor to the disease, treatment with corticosteroids c...

journal_title：Current drug targets

authors： Saffar AS,Ashdown H,Gounni AS

更新日期：2011-04-01 00:00:00

abstract：:Dysbiosis has been repeatedly observed in inflammatory bowel disease (IBD) and is now recognized as an essential factor in the gut inflammatory process. IBD is a significant burden to health-care systems, mainly due to treatment-related costs. Available treatments have several limitations: up to 30% of patients are pr...

journal_title：Current drug targets

authors： Zatorski H,Nakov R

更新日期：2020-01-01 00:00:00

abstract：:PDZ domains play an essential role in a number of cellular processes by facilitating protein scaffolding and assembly of protein complexes. These domains consist of 80 to 90 amino acids and are found to recognize short C-terminal sequences of target proteins. Protein complex formation between PDZ target molecules can ...

journal_title：Current drug targets

authors： Holcomb J,Spellmon N,Trescott L,Sun F,Li C,Yang Z

更新日期：2015-01-01 00:00:00

abstract：:Hepatitis C virus (HCV), a member of the Flaviviridae family, has been recognised to be responsible for both parenterally transmitted and sporadic non-A and non-B hepatitis affecting 1-3% of the world population. HCV is a positive stranded RNA virus encoding a single polyprotein which contains at least ten unique stru...

journal_title：Current drug targets

authors： Lahm A,Yagnik A,Tramontano A,Koch U

更新日期：2002-08-01 00:00:00

abstract：:The emergency of responsive drug delivery systems has contributed to the reduced cytotoxicity, the improved permeability in tissues and extended circulation time of the active drug. Of particular, enzyme-responsive nanoplatforms have attracted a lot due to the specificity and efficiency of an enzyme-catalyzed reaction...

journal_title：Current drug targets

authors： Lou XF,Du YZ,Xu XL

更新日期：2021-01-13 00:00:00

abstract：:Methionine aminopeptidases (MetAP) are intracellular metalloproteins responsible for the removal of the initiator NH(2)-terminal methionine from newly synthesized proteins, thereby facilitating their intracellular translocation from the ribosome. Two types of MetAP enzymes, MetAP-1 (type-I) and MetAP-2 (type-II), whic...

journal_title：Current drug targets

authors： Mauriz JL,Martín-Renedo J,García-Palomo A,Tuñón MJ,González-Gallego J

更新日期：2010-11-01 00:00:00

abstract：:Epigenetic modifications ensure the maintenance of normal cellular functions, and their dysregulation is frequently found in many disease states, including cancer. Nowadays, the most studied epigenetic dysregulation associated with tumorigenesis, cancer progression and metastasis refers to the variations in DNA methyl...

journal_title：Current drug targets

authors： Lin SQ,Li X

更新日期：2020-01-01 00:00:00

abstract：:The Wnt signaling pathway has important functions in development, tissue homeostasis, and regeneration. Deregulation of canonical Wnt/beta-catenin signaling is frequently found in various human cancers, particularly in colorectal cancer, and non-canonical Wnt signaling pathways also have been implicated in neoplasia. ...

journal_title：Current drug targets

authors： Qi J,Zhu YQ

更新日期：2008-07-01 00:00:00

abstract：:Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of increased basal oxidative stress. Since this state of oxidative stress makes cancer cells vulnerable to agents that further augment ROS levels, the use of pro-oxidant agents is emerging as an exciting strategy to selectively targ...

journal_title：Current drug targets

authors： Martin-Cordero C,Leon-Gonzalez AJ,Calderon-Montano JM,Burgos-Moron E,Lopez-Lazaro M

更新日期：2012-07-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are the leading cause of death, chronic illness and disability in Western countries. The most common cause of CVD derives from the harmful effects of acute myocardial ischemia and subsequent reperfusion injury. Cardioprotection against acute ischemia/ reperfusion injury is made possible b...

journal_title：Current drug targets

authors： Penna C,Granata R,Tocchetti CG,Gallo MP,Alloatti G,Pagliaro P

更新日期：2015-01-01 00:00:00

abstract：:There exists an immediate need to develop novel medications for the treatment of mood disorders such as bipolar disorder and depression. Initial interest in glycogen synthase kinase-3 (GSK-3) as a target for the treatment of mood disorders arose from the finding that the mood stabilizing drug lithium directly inhibite...

journal_title：Current drug targets

authors： Gould TD,Picchini AM,Einat H,Manji HK

更新日期：2006-11-01 00:00:00

abstract：:The incidence of lung cancer in 2007 is estimated to be 213,380 with 160,390 deaths in the United States. It will contribute to 31% of male and 26% of female cancer-related deaths and is the largest cause of cancer-related mortality in both men and women. Despite some advances in the treatment of advanced non-small ce...

journal_title：Current drug targets

authors： Chen M,Shao W,He J,Wang D

更新日期：2010-01-01 00:00:00

abstract：:Classical antidepressant drugs such as Selective Serotonin Reuptake Inhibitors (SSRIs) display several disadvantages, e.g., the onset of action (2 to 3 weeks) to start clinical benefits is too long, and a significant proportion of patients do not respond to this monotherapy. Several strategies have been proposed to ov...

journal_title：Current drug targets

authors： Guiard BP,Lanfumey L,Gardier AM

更新日期：2006-02-01 00:00:00

abstract：:Most pathological conditions that result in human diseases are associated with altered gene expression. With the advent of new technologies that might control gene expression and a broader knowledge of transcription factors and pathways, new strategies have emerged that offer promising first results for therapeutical ...

journal_title：Current drug targets

authors： Quarcoo D,Hamelmann E

更新日期：2006-06-01 00:00:00

abstract：:FOXO transcription factors control proliferation, apoptosis, differentiation and metabolic processes. Loss of FOXO function has been identified in several human cancers, and results in increased cellular survival and a predisposition to neoplasia, especially in epithelial cancer. FOXO factors are therefore bona fide t...

journal_title：Current drug targets

authors： Monsalve M,Olmos Y

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The intracellular multiprotein complex termed the inflammasome functions as a platform of pro-inflammatory cytokine production such as IL-1β and IL-18. Under certain conditions, however, the inflammasome produces non-canonical effects such as induction of cell death, pyroptosis and cell metabolism alteration...

journal_title：Current drug targets

authors： Conley SM,Abais JM,Boini KM,Li PL

更新日期：2017-01-01 00:00:00

abstract：:Inflammation is a risk factor for cancer development in several tissues. In the colorectum, inflammatory bowel disease (ulcerative colitis and Crohn's disease) is a longstanding inflammatory disease with increased risk for colorectal cancer (CRC). Several molecular events involving in chronic inflammatory process cont...

journal_title：Current drug targets

authors： Tanaka T

更新日期：2012-12-01 00:00:00

abstract：:RNA, as an intermediate in the production of every gene encoded protein and the genetic material of many pathogenic viruses, presents an attractive target for both biological and therapeutic manipulation. Despite its extensive involvement in living systems, its chemical diversity based on four units is relatively low ...

journal_title：Current drug targets

authors： Cairns MJ,Saravolac EG,Sun LQ

更新日期：2002-06-01 00:00:00

abstract：:Phytometabolites are functional elements derived from plants and most of them exhibit therapeutic characteristics such as anti-cancer, anti-inflammatory and anti-oxidant effects. Phytometabolites exert their anti-cancer effect by targeting multiple signaling pathways. One of the remarkable phenomena targeted by phytom...

journal_title：Current drug targets

authors： Hasanpourghadi M,Looi CY,Pandurangan AK,Sethi G,Wong WF,Mustafa MR

更新日期：2017-01-01 00:00:00

abstract：:Transport molecules can significantly affect the pharmacodynamics and pharmacokinetics of drugs. An important transport molecule, the 170 kDa P-glycoprotein (Pgp), is constitutively expressed at several organ sites in the human body. Pgp is expressed at the blood-brain barrier, in the kidneys, liver, intestines and in...

journal_title：Current drug targets

authors： Liang XJ,Aszalos A

更新日期：2006-08-01 00:00:00

abstract：:Epidemiological studies provide a growing number of evidences that chronic exposure to relatively low levels of cadmium (Cd), nowadays taking place in industrialized countries, may cause health hazard. Thus, growing interest has been focused on effective ways of protection from adverse effects of exposure to this heav...

journal_title：Current drug targets

authors： Brzóska MM,Borowska S,Tomczyk M

更新日期：2016-01-01 00:00:00